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All Journal Universa Medicina JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Academic Hospital Journal Indonesian Journal of Pharmacology and Therapy
Firda Ridhayani
Department Of Pharmacology And Therapeutics, Faculty Of Medicine, Public Health, And Nursing, Universitas Gadjah Mada
Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Discordance of HER2 between primary tumors and lymph node metastatic lesions in invasive breast cancer Nugrohowati, Noviana; Anwar, Sumadi Lukman; Juwaryani, Juwaryani; Ridhayani, Firda
Universa Medicina Vol. 44 No. 1 (2025)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2025.v44.43-49

Abstract

BackgroundBreast cancer therapy is mostly influenced by the type and molecular subtype, especially in the case of human epidermal growth factor receptor 2 (HER2) status, where HER2-positive patients will receive anti-HER2 therapy. HER2 status is obtained from HER2 immunohistochemistry examination which can be performed on primary breast tumors or lymph node metastatic lesions. This study aimed to determine the concordance of HER2 status between primary tumors and lymph node metastatic lesions in invasive breast cancer. MethodsA cross-sectional study was conducted involving 30 invasive breast cancer patients. HER2 immunohistochemistry examination was carried out on both the primary tumor and lymph node metastatic lesions. The Cohen κ coefficient was used to analyse the data. Results The concordance rate for HER2 was 86.67%. Thirteen cases were concordantly HER2-negative in primary breast cancer (BC) and nodal metastases, and 13 cases were HER2-positive in both primary and metastatic tumors. Changes in HER2 status between primary BC and corresponding synchronous metastases were observed in four (4.72%) cases. One of the discordant cases was HER2-negative in the primary tumor and HER2-positive in the metastases, while three cases were HER2-positive in the primary breast cancer and HER2- negative in the metastases. Conclusion There is a discordance of HER2 status between the primary tumor and lymph node metastases in invasive breast cancer patients. It is necessary to evaluate the HER2 status of the primary tumor and metastases simultaneously. Such an evaluation is recommended for better prognosis and survival.
Assessment of one-year overall survival among stage III breast cancer patients Darwito; Sari, Ika Puspita; Wijayana, Singgih; Mahardinata, Nur Azid; Anwar, Sumadi Lukman; Ridhayani, Firda
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 16, No 2, (2025)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol16.Iss2.art6

Abstract

Background: The results of a comprehensive diagnosis, combined with the individual's general state, establish the appropriate therapeutic care for breast cancer patients. These management disparities have an impact on clinical outcomes, which may influence patient survival. The evaluation process of breast cancer management is essential as a strategy to boost the therapy's effectiveness in the future year. Objectives: Assessing survival rate, one-year overall survival, among stage III breast cancer patients.Methods: An observational study was conducted comprising a retrospective cross-sectional study. Data collected retrospectively from the medical record followed a total sampling technique. This study included patients with breast cancer as a main diagnosis with or without comorbidities and aged ≥ 18 years when undergoing their first diagnosis. Moreover, the exclusion criteria were patients who had incomplete medical record data, undergoing breast cancer treatment at other healthcare facilities, unspecified clinical stage, and patients who had been diagnosed with non-stage III breast cancer. The survival time of the participants is defined as the number of months from initial diagnosis to their last status (alive, died, or loss of follow-up). One-year overall survival was projected using the Kaplan-Meier curve and presented as a percentage with a 95% confidence interval. Results: Of the 23 patients with stage III breast cancer and the mean age was 57.39 ± 10.417 years. The one-year overall survival for stage III breast cancer was 78.3%. In addition, metastases conditions were associated with worse one-year overall survival compared to patients without metastases (40.0% vs 88.9%, p=0.028).Conclusion: The survival rate of breast cancer patients remains lower than in another recent study from Indonesia. This indicates the requirement of treatment strategies evaluation.
Clinically significant of drug-drug interactions among children: a review Ridhayani, Firda; Sari, Ika Puspita; Andayani, Tri Murti
Indonesian Journal of Pharmacology and Therapy Vol 5 No 3 (2024)
Publisher : Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijpther.9663

Abstract

Drug-drug interactions among children are a getting along concern in health care settings, specifically intensive care units, as sources of adverse drug events that may affect patient condition. Children admitted to pediatric intensive care unit are more prone to drug-drug interactions owing to the diseases and medications complexity. This condition could put the patient at high risk of harm, particularly with his critical condition, so need intense considerations from clinical practitioners to prevent adverse drug events caused by potential drug-drug interactions. This article’s review attempts to explore the important drug-drug interactions among children, including explaining the drug combination, mechanism, and related adverse drug events to help health practitioners recognize it earlier before prescribing the medication. This article’s review explored previous research results from PubMed and Google Scholar as literature resources and PRISMA flow chart as protocol for article selection process. A total of 9 articles discussed comprehensively about the type of drug combinations, mechanism of drug-drug interactions, and associated adverse drug events with significant drug-drug interactions that commonly occurred in children’s patient during the treatment. The drug-drug interaction including midazolam-phenobarbital, cannabidiol-clobazam, Paxlovid-tacrolimus, inhaled fluticasone propionate-lopinavir/ritonavir, rifampicin-warfarin, clofazimine-moxifloxacin, benzatropine-haloperidol, and enalapril-spironolactone. In conclusion, gaining a better understanding of drug-drug interactions among children will empower healthcare professionals to develop useful strategies to recognize, manage, and prevent various types of pharmacokinetic and pharmacodynamic interactions. Especially at different stages in terms of age, physiology, and complexity of the disease in children.
Childhood Masturbation: A Case Report and Literature Review for Treatment Lestari, Ade Febrina; Sitaresmi, Mei Neni; Ridhayani, Firda
Academic Hospital Journal Vol 5, No 1 (2023)
Publisher : Rumah Sakit Akademik Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ahj.v5i1.81830

Abstract

Background: Masturbation is normal sexual behavior. However, masturbation in childhood is rarely discussed in the research. Childhood masturbation or gratification disorder, is characterized by self-stimulation of genitalia in prepubescent children. However, childhood masturbation often stops if the child is distracted, and spontaneous recovery within two years in most cases Generally, no drug therapy is required for childhood masturbation unless it is very frequent or excessive and it affects the daily functionality of the child. Regarding the treatment of childhood masturbation, we highlight the fact that evidence-based therapy for childhood masturbation is lacking due to unclear standard guidelines on it. We need a path of therapy that can help doctors in the management of childhood masturbation. Case: Here we reported two cases of excessive childhood masturbation from a 3-year-old and a 10-month-old female patient who were brought by their mother to the outpatient clinic pediatric, Academic Hospital, Universitas Gadjah Mada, Indonesia, with a complaint of stretching by flexing the legs and rubbing on her genital part Risperidone as one of the drug therapies for this case and present a good outcome. Additionally, this article also provides literature reviews on childhood masturbation treatment that may guide clinicians in its evaluation and management. Conclusion:  We conclude that behavioral treatment is the common strategy for childhood masturbation.  The treatment, as well as behavioral and drug therapeutic strategies, should be considered to achieve an effective outcome.
Comparison between metformin and glibenclamide as antidiabetic oral in gestational diabetes mellitus: a review Ridhayani, Firda; I Dewa Agung Ayu Diva Candraningrat; Ilmi Nurhafizah; Karina Nurlitasari; Mardiana Siregar
Indonesian Journal of Pharmacology and Therapy Vol 4 No 1 (2023)
Publisher : Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijpther.5867

Abstract

Gestational diabetes mellitus (GDM) is one of the most frequent clinical complications during pregnancy that affects up to 6% of women with pregnancies around the world. Gestational diabetes mellitus treatment used insulin as first-line therapy. In addition, several professional associations are also considering treatment using antidiabetic oral which has equivalent efficacy compared with insulin. However, many oral antidiabetic recommendations have been administered to treat GDM, including metformin and glyburide or glibenclamide. This article’s review aims to compare the usage between metformin and glyburide or glibenclamide in GDM patients. This review compared research results from PubMed as literature resources and the PRISMA flow chart as the protocol for the article selection process. Based on inclusion and exclusion criteria there are six research articles that are appropriate to the article’s topic and aim. Metformin is superior compared with glyburide or glibenclamide administration as antidiabetic oral in GDM. Metformin showed a significant effect in lowering preprandial and postprandial glucose level, elevating insulin sensitivity, while glibenclamide administration decreased dynamic pancreatic β-cell responsivity significantly and had a higher risk compared with insulin and metformin.
Adverse events following immunization (AEFIs) in health workers who receive COVID-19 vaccination at Academic Hospital Universitas Gadjah Mada, Yogyakarta Lestari, Ade Febrina; Sitaresmi, Mei Neni; Haspitaningrum, Anjarsari; Rachmasari, Kusuma Ayu; Wulandari, Ratih; Sari, Shinta Kusumalarna; Ridhayani, Firda
Indonesian Journal of Pharmacology and Therapy Vol 4 No 1 (2023)
Publisher : Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijpther.6860

Abstract

COVID-19 is a new viral infection that has become a global pandemic, resulting in extremely high mortality and morbidity rates worldwide, including in Indonesia. Vaccination is one of the strategies for preventing COVID-19 infection promoted by the World Health Organization (WHO) to reduce COVID-19 morbidity and mortality. The Indonesian government supports the implementation of vaccination and conducts mass vaccination as a strategy to overcome the pandemic in Indonesia. The high immunization coverage resulted in increased use of vaccines, and events following immunization (AEFI) also increased. Reports on follow-up AEFI are needed as government policy references and information for the public. This study aims to describe the following events after the COVID-19 vaccine immunization and the incidence of the infection post vaccination. The study design was a cross-sectional study using primary and secondary data. The data were analyzed descriptively and statistically using Chi Square method by identifying association between demographic data and AEFI incidence. A total 131 respondents were included. Most respondents experienced AEFI after giving the first (77.1%) or second (71.9%) vaccine with the Sinovac vaccine. However, all reported mild AEFI. Most reported AEFIs were pain (48.8% and 49.6%), hungry (37.4% and 10.0%), and drowsiness (32.1% and 23.7%) after the first and the second vaccine. In conclusion, the prevalence of AEFI in the first and the second dose of inactivated COVID-19 vaccine is higher than that reported in the clinical trial study although the all AEFIs are considered as mild.
Papillary thyroid carcinoma post total thyroidectomy: a case report Darwito; Ardha, Doglas Rama Bayu; Sari, Ika Puspita; Ridhayani, Firda
Indonesian Journal of Pharmacology and Therapy Vol 4 No 2 (2023)
Publisher : Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijpther.6980

Abstract

Thyroid malignancies are considered rare but it is the most common type of endocrine malignancy that increase rapidly over the past decades. Specifically, papillary thyroid carcinoma (PTC) in the pyramidal lobe is extremely rare. Herein, we described a case of recurrence case of PTC in the pyramidal lobe post total thyroidectomy with category VI T2N1M1 (Bethesda classification) with right neck lymph nodes metastasis at once and attempt to determine both clinical presentation and therapeutical strategies to overcome this case to diminish the possibility of tumor recurrence and optimize therapeutic outcomes for PTC recurrence. It was reported a 28 yo female with a diagnosis of PTC from the pyramidal lobe post-total thyroidectomy procedure. A definite diagnosis of PTC is important to understand the patient's condition and as a consideration to decide the appropriate procedure to cure it. The management of PTC with total thyroidectomy followed by removing the possible root source of recurrent PTC, such as the pyramidal lobe, is mandatory to minimize the residual thyroid tissue that dan influenced PTC recurrent. Even though almost all PTC has an excellent prognosis, periodic follow-up after surgery, and patients’ adherence to their medication are still required.
Co-Authors Ade Febrina Lestari Anjarsari Haspitaningrum Anwar, Sumadi Lukman Ardha, Doglas Rama Bayu Darwito Darwito Doglas Rama Bayu Ardha Haspitaningrum, Anjarsari I Dewa Agung Ayu Diva Candraningrat I Dewa Agung Ayu Diva Candraningrat Ika Puspita Sari Ika Puspita Sari Ilmi Nurhafizah Ilmi Nurhafizah Juwaryani, Juwaryani Karina Nurlitasari Karina Nurlitasari Kusuma Ayu Rachmasari Lestari, Ade Febrina Mahardinata, Nur Azid Mardiana Siregar Mardiana Siregar Mei Neni Sitaresmi Nugrohowati, Noviana Rachmasari, Kusuma Ayu Ratih Wulandari Ratih Wulandari Sari, Shinta Kusumalarna Shinta Kusumalarna Sari Tri Murti Andayani Wijayana, Singgih