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All Journal HAYATI Journal of Biosciences Indonesian Journal of Cancer Chemoprevention Indonesian Journal of Biotechnology INDONESIAN JOURNAL OF PHARMACY The Indonesian Biomedical Journal
Jenie, Riris Istighfari
Cancer Chemoprevention Research Center, Faculty Of Pharmacy, Universitas Gadjah Mada, Jl. Sekip Utara Sleman, Yogyakarta 55281
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Earth & Planetary Sciences Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Journal : INDONESIAN JOURNAL OF PHARMACY

 1 
Snake beans (Vigna sinensis (L) Savi ex Hassk) extract increases breast epithelial cells proliferation Edy Meiyanto; Sri Handayani; Riris Istighfari Jenie
Indonesian Journal of Pharmacy Vol 19 No 4, 2008
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1596.989 KB) | DOI: 10.14499/indonesianjpharm0iss0pp191-197

Abstract

Some Javaness people use snake beans for skin and breast care, especially for better breast development. This research was conducted to examine the effect of snake beans extract (EKP) on the breast epithelial cells proliferation on in vitro and in vivo models. The in vitro experiment was carried out against MCF-7 cells using MTT assay and morphologically examination was carried out under light microscope. Sprague Dawley female Rats were used in in vivo experiment. The rats (30 days of age) were separated into 3 groups, namely base line group, control group, and treatment groups. The extract was administered in the dose of 1000 mg/kgBW p.o. every day for 14 days then the rats were examined for wet uterus weight, lobulus development, and estrogen receptor (ER) expression. Extract treatment induced MCF-7 cells proliferation in dose dependent manner. The extract exhibited proliferative effect in the dose of 50 ug/mL 300 ug/mL, but in the dose of 400 ug/mL and 500 ug/mL the extract inhibited cells proliferation and there were no cell death effect. Extract treatment in the dose of 1000 mg/kgBW tended to increase uterus weight. The extract also increased lobulus development up to two fold and induced estrogen receptor expression in epithelial cells of lobulus and ductus. These results conclude, snake bean (in appropriate dose) induces breast glands development and relatively safe (no death effect on the cells), therefore can be developed for breast care product.Key words: Snake bean, breast care, proliferation, lobulus epithelial cells, estrogen receptor
Antiangiogenic effect of sambung nyawa leaves (Gynura procumbens (Lour.) Merr.) etanolic extract on chick embryo chorioallantoic membrane (CAM) Riris Istighfari Jenie; Edy Meiyanto; Retno Murwanti
Indonesian Journal of Pharmacy Vol 17 No 1, 2006
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (411.767 KB) | DOI: 10.14499/indonesianjpharm0iss0pp50-55

Abstract

Antiangiogenesis (inhibition of new blood vessels formation) has become a strategy to inhibit cancer development lack of nutrition and oxygen supply. The aim of the present research is to investigate antiangiogenesis effect of ethanolic extract of Gynura procumbens (Lour.) Merr. Leaves in situ using chick embryo chorioallantoic membrane (CAM). Eight to 9 days old fertilized chicken eggs were treated with b-FGF (angiogenesis inductor) and extracts. Eggs were then incubated for 3 days in order to observe its angiogenesis response (new blood vessels converged toward the implant).The results showed that the ethanolic extract of G.procumbens could inhibit angiogenesis in a dose-dependent manner. Doses 10, 20, 40, 80 ug gave angiogenesis response of (in percent) 82.32 ± 6.33; 68.38 ± 6.24; 56.48 ± 11.61; 41.43 ± 7.46 (p<0.05), respectively. These results indicate a potential antiangiogenic effect of the extract.Key words: antiangiogenic, CAM, G.procumbens.
Co-Authors Adam Hermawan Akhmad Darmawan Amalia Miranda Amalia Miranda Annisa Novarina Argandita Meiftasari Bani Adlina Shabrina Bani Adlina Shabrina Devi Nisa Hidayati Diah Tri Utami Dwi Sulistyowati Edy Meiyanto Edy Meiyanto Edy Meiyanto Edy Meiyanto Edy Meiyanto Edy Meiyanto Edy Meiyanto Een Sri Endah Fahmi Rosyadi Fajar Aji Lumakso Hilyatul Fadliyah Ika Rahmawati Sutejo Imroatus Sholihah Januar Caesar W.P. Julika Yovi W. Khairunisa Irnanda Laeli Muntafiah Laely Muntafiah Laili Nailul Muna Lina Permatasari Luthfia Indriyani Meirizky Zulharini Meirizky Zulharini S. Meirizky Zulharini S. Murah Riski Novi Asshagab Muthi Ikawati Nadzifa Nugraheni Nita Kristiani Prisnu Tirtanirmala Puspa Dewi Narrij Lotulung Rahmawaty Rachmady Raisatun Nisa Sugiyanto Ratna Asmah Susidarti Ratna Asmah Susidarti Refki Riswansyah Retno Murwanti Rohmad Yudi Utomo Rumiyati Rumiyati Sri Handayani Sri Handayani Sri Handayani Sri Handayani Sri Handayani Sri Handayani Sri Pudjiraharti Yogi Ertanto Zalinar Udin Zalinar Udin