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All Journal Disease Prevention and Public Health Journal The Indonesian Biomedical Journal BALABA (JURNAL LITBANG PENGENDALIAN PENYAKIT BERSUMBER BINATANG BANJARNEGARA) Jurnal Litbang Kota Pekalongan
Siwi Pramatama Mars Wijayanti
Department Of Public Health, Faculty Of Health Sciences, Universitas Jenderal Soedirman, Jl. Dr. Soeparno 63, Purwokerto
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Computer Science & IT Immunology & microbiology Medicine & Pharmacology Public Health Veterinary

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Staphylococcus aureus and Pseudomonas aeruginosa in Tubotympanic Chronic Suppurative Otitis Media Patients in Purwokerto, Indonesia Daniel Joko Wahyono; Anton Budhi Darmawan; Leader Alfason; Reinhard Simbolon; Siwi Pramatama Mars Wijayanti; Wisiva Tofriska Paramaiswari; Korrie Salsabila; Dodi Safari
The Indonesian Biomedical Journal Vol 12, No 4 (2020)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v12i4.1218

Abstract

BACKGROUND: Chronic Suppurative Otitis Media (CSOM) causes hearing impairment and frequently occurred in low-income country where medical care and personal hygiene are poor. Staphylococcus aureus and Pseudomonas aeruginosa are the most common cause of CSOM. We investigated prevalence and antimicrobial susceptibility of S. aureus and P. aeruginosa from tubotympanic CSOM patients in tertiary hospital, Purwokerto, Indonesia in 2016-2017.METHODS: Ear swab specimens were collected from patients with tubotympanic CSOM. S. aureus and P. aeruginosa were isolated and identified by culture, matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS), and molecular tools. Antimicrobial susceptibility testing was performed using the disk diffusion method.RESULTS: Out of ear swabs from 34 patients with tubotympanic CSOM, P. aeruginosa and S. aureus were identified in 35%patients. No Methicillin-resistant S. aureus (MRSA) strain was found from the ear swabs of the patients with tubotympanic CSOM. Bacterial identification using the MALDI-TOF MS was concordantly with culture and molecular tools. All S. aureus isolates showed full susceptibility to cefoxitin and trimethoprim-sulphamethoxazole. Resistance to tetracycline was common with only 64% of S. aureus strains being susceptible. Meanwhile, all P. aeruginosa strains were susceptible to cefepime, cetazidime, meropenem, gentamicin, and tobramycin.CONCLUSION: S. aureus and P. aeruginosa are found in patients with tubotympanic CSOM and still susceptible to different antibiotic agents. MALDI-TOF MS demonstrate rapid, accurate and robust to detect S. aureus and P. aeruginosa.KEYWORDS: Staphylococcus aureus, Pseudomonas aeruginosa, chronic tubotympanic suppurative otitis media
Seroprevalence of Japanese enchephalitis Infection in Pigs in Tulungagung, East Java Dyah Widiastuti; Tri Wijayanti; Tri Isnani; Nova Pramestuti; Siwi Mars Pramatama Wijayanti
BALABA: JURNAL LITBANG PENGENDALIAN PENYAKIT BERSUMBER BINATANG BANJARNEGARA Volume 15 Nomor 2 Desember 2019
Publisher : Balai Penelitian dan Pengembangan Kesehatan Banjarnegara Badan Litbangkes Kemenkes RI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (376.08 KB) | DOI: 10.22435/blb.v15i2.1888

Abstract

Pigs play a role as amplifier hosts for Japanese enchephalitis (JE). Surveillance of JEV infection on pigs, is, therefore undoubtedly important to prevent its transmission to humans. This study aims to investigate the infection rates of JE in pigs as a risk of JE in human. The study area was located in Tulungagung regency, one of the regencies in East Java with the largest number of pig farms. This was a cross sectional study, involving five pig farms in Tulungagung Regency during April-November 2016, with a total of 63 pigs examined. Venous blood was examined by JEV specific IgG-Enzyme Link Immuno-Sorbent Assay (ELISA). The results showed that the JE infection rates in overall pig samples was 19.05% (12/63). The prevalence of Ab JE in 4-6 month pigs is higher (22.7%) than in 2-3 month pigs. The infections in pigs tend to be higher (23.1%) in farms found to be positive for Culex larvae. Sex and age of the pig and the presence of Culex larvae surround pig farms were not significantly associated with JE infection rates in pigs. In conclusion, the presence of JE virus antibodies in pigs population in Tulungagung indicates that there is a potency of JE virus transmission to humans.
EKSPLORASI POTENSI EKSTRAK CAIR DAUN KECOMBRANG YANG MENGANDUNG ANTIOKSIDAN SEBAGAI PENETRALISIR RADIKAL BEBAS DALAM DARAH PETUGAS SPBU Azzah Farah Fadiyah; Resi Mukti Wardhani; Nurmei Rahmatika; Siwi Pramatama Mars Wijayanti
JURNAL LITBANG KOTA PEKALONGAN Vol. 15 (2018)
Publisher : Badan Perencanaan Pembangunan, Penelitian dan Pengembangan Daerah (Bappeda) Kota Pekalongan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54911/litbang.v15i0.72

Abstract

ABSTRAK Pekerjaan sebagai petugas Stasiun Pengisian Bahan Bakar Umum (SPBU) memiliki risiko akibat paparan radikal bebas di lingkungan SPBU yang dapat menyebabkan modifikasi lipid, DNA, dan protein pada berbagai jaringan tubuh. Untuk menetralisir radikal bebas tersebut tubuh memiliki antioksidan alami yaitu Superoksida Dismutase (SOD). Daun kecombrang memiliki kandungan antioksidan terutama flavonoid yang mampu menetralisir radikal bebas. Oleh karena itu, bertujuan mengeksplorasi potensi ekstrak cair daun kecombrang sebagai penetralisir radikal bebas dalam darah. Metode penelitian ini merupakan penelitian eksperimen yang diujikan pada tikus. Langkah yang dilakukan dalam penelitian ini antara lain pembuatan ekstrak daun kecombrang, perlakuan terhadap hewan uji dan pemeriksaan kadar SOD serum darah hewan uji. Hewan uji berupa tikus jantan galur Wistar sebanyak 16 ekor yang dibagi menjadi 4 kelompok, yaitu kelompok kontrol positif yang diinduksi CCL4 1mL/KgBB dan placebo berupa Na-CMC 1%, kelompok perlakuan 1 yang diinduksi CCL4 1mL/KgBB dan ekstrak daun kecombrang 100mg/KgBB, kelompok perlakuan 2 yang diinduksi CCL4 1mL/KgBB dan ekstrak daun kecombrang 150mg/KgBB, dan kelompok perlakuan 3 yang diinduksi CCL4 1mL/KgBB dan ekstrak daun kecombrang 200mg/KgBB. Masing-masing kelompok terdiri dari 4 ekor tikus. Berdasarkan hasil eksperimen pengukuran kadar SOD didapati hasil bahwa ekstrak daun kecombrang dapat meningkatkan kadar SOD serum darah tikus yang diinduksikan CCL4 sebagai radikal bebas. Berdasarkan hasil eksperimen juga diketahui bahwa dosis optimal ekstrak cair daun kecombrang untuk meningkatkan kadar SOD serum darah pada subjek penelitian adalah 150mg/KgBB. Dari penelitian ini diketahui bahwa ada potensi untuk mengembangkan ekstrak cair daun kecombrang sebagai penetralisisr radikal bebas. Kata Kunci: Ekstrak cair daun kecombrang, Radikal bebas, Antioksidan, SOD, In Vivo
Factors Affecting the Quality of Life of Breast Cancer Patients Alifka Deti Sri Maharani; Dwi Sarwani Sri Rejeki; Siwi Pramatama Mars Wijayanti
Disease Prevention and Public Health Journal Vol. 17 No. 2 (2023): Disease Prevention and Public Health Journal
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/dpphj.v17i2.8705

Abstract

Background: Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer death among women worldwide in 2020. This systematic review aims to identify the factors that affect the quality of life of breast cancer patients so that the results of this systematic ventilation can help health professionals develop appropriate interventions. Method: This systematic review followed the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) guidelines. This study aims to identify the factors that affect the quality of life of breast cancer patients. A comprehensive search was performed across several databases, including PubMed, Embase, Scopus, and Web of Science. The search was limited to studies published between 2019 and 2022, which were written in English. Results: Factors that affect the quality of life of breast cancer patients include age, education level, social support, psychological stress and anxiety, economic status, depression, and physical symptoms. Conclusion: Several factors can affect the quality of breast cancer patients, so the patient needs support from the family and health policies from the government in their treatment.
Co-Authors Alifka Deti Sri Maharani Anton Budhi Darmawan Azzah Farah Fadiyah Daniel Joko Wahyono Dodi Safari Dwi Sarwani Sri Rejeki Dyah Widiastuti Elviera Gamelia Korrie Salsabila Leader Alfason Nova Pramestuti Nurmei Rahmatika Reinhard Simbolon Resi Mukti Wardhani Tri Isnani Tri Wijayanti Wisiva Tofriska Paramaiswari