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All Journal Sari Pediatri Bioscientia Medicina : Journal of Biomedicine and Translational Research Bioscientia Medicina : Journal of Biomedicine and Translational Research Conferences of Medical Sciences Dies Natalis
Hertanti Indah Lestari
Bagian Ilmu Kesehatan Anak Fakultas Kedokteran Universitas Sriwijaya/RSUP Dr. Mohammad Hoesin, Palembang
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Nefritis Tubulointerstisialis pada Kasus Anak yang Menjalani Biopsi Ginjal Hertanti Indah Lestari; Partini Pudjiastuti Trihono
Sari Pediatri Vol 12, No 4 (2010)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (70.349 KB) | DOI: 10.14238/sp12.4.2010.247-53

Abstract

Latar belakang. Nefritis tubulointerstisialis (NTI) adalah sindrom yang merupakan spektrum penyakit akutdan kronik, yang secara histologis ditandai oleh inflamasi dan kerusakan struktur tubulus dan interstisial,dengan sedikit pengaruh pada elemen glomerular dan vaskular. Diagnosis pasti ditegakkan berdasarkanbiopsi ginjal, karena tidak ada pemeriksaan klinis dan penunjang non invasif yang spesifik dan sensitif.Tujuan. Mengetahui gambaran histopatologi yang menunjukkan keterlibatan tubulointerstisialis sertahubungannya dengan gambaran klinis dan laboratorium pada kasus anak usia kurang dari 18 tahun yangmenjalani biopsi ginjal pada periode 2005-2009.Metode. Penelitian retrospektif deskriptif dengan sumber data sekunder rekam medik Departemen IlmuKesehatan Anak dan Departemen Patologi Anatomi Fakultas Kedokteran Universitas Indonesia – RS Dr.Cipto Mangunkusumo Jakarta.Hasil. Terdapat 45 kasus anak yang menjalani biopsi ginjal, terdiri dari 24 orang laki-laki dan 21 perempuanyang berusia 6 bulan sampai 16 tahun. Indikasi biopsi adalah glomerulonefritis akut, sindrom nefrotik,nefritis lupus, dan tumor ginjal. Gambaran klinis yang ditemukan yaitu edema, hipertensi, oliguria, demam,pucat, dan muntah. Gambaran laboratorium yaitu peningkatan kreatinin, asidosis metabolik, hipokalemia,proteinuria, hematuria, dan leukosituria steril. Gambaran nefritis tubulointerstisialis adalah infiltrasi selradang kronik, atrofi tubulus, fibrosis interstisialis, dan edema interstisialis. Beberapa gejala yang lebihbanyak terjadi pada pasien dengan lebih atau sama dengan satu kelainan tubulointerstisialis yaitu demam(p<0,05), anemia, muntah, dan asidosis metabolik.Kesimpulan. Nefritis tubulointerstisialis sebagai suatu entitas diagnosis cukup banyak ditemukan dan perludiberikan lebih banyak perhatian, dalam upaya menurunkan morbiditas dan mortalitas dari penyakit ginjalpada anak. 
Kelainan Mineral Tulang pada Anak dengan Penyakit Ginjal Kronik Hertanti Indah Lestari; Eka Intan Fitriania; Aditiawati Aditiawati; Minerva Riani Kadir
Sari Pediatri Vol 21, No 5 (2020)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/sp21.5.2020.282-8

Abstract

Latar belakang. Penderita penyakit ginjal kronis (PGK) berisiko mengalami abnormalitas mineral, sejalan dengan penurunan laju filtrasi glomerulus (LFG) atau peningkatan stadium PGK. Di Palembang, belum ada laporan mengenai penyakit mineral tulang pada anak akibat penyakit ginjal kronik. Tujuan. Penelitian ini bertujuan mengetahui kejadian penyakit mineral tulang pada anak dengan PGK.Metode. Penelitian potong lintang untuk mengetahui kejadian penyakit mineral tulang akibat PGK, dengan pemeriksaan kadar hormon paratiroid, kadar vitamin D, serta pemeriksaan densitas tulang. Subyek penelitian dibagi menjadi kelompok 1 (PGK stadium 1-2) dan kelompok 2 (PGK stadium 3-5). Hasil. Dari 28 subyek penelitian, rerata usia 10,7 tahun, rasio laki-laki dan perempuan, yaitu 2,5:1. Berdasarkan stadium PGK, 14 subyek dengan stadium 1. Rerata kadar hormon paratiroid pada PGK stadium 3-5 secara bermakna lebih tinggi. Subyek dengan PGK stadium 3-5 memiliki risiko 2x lebih besar mengalami hiperparatiroid. Kejadian defisiensi/insufisiensi vitamin D didapatkan pada 23 subyek (82%). Kejadian defisiensi/insufisiensi vitamin D tidak berbeda bermakna di antara kedua kelompok. Penurunan densitas tulang terjadi pada 8 subyek , 5 diantaranya osteopenia, dan 3 lainnya osteoporosis. Kesimpulan. Semua anak dengan PGK baik stadium 1-2 maupun 3-5 menunjukkan tanda kelainan mineral tulang secara laboratorium dan/atau densitometri.
The Status of Oxidants and Antioxidants in Children with Nephrotic Syndrome Hertanti Indah Lestari; Eka Febri Zulissetiana; Ardesy Melizah
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 2 No. 1 (2018): Bioscientia Medicina: Journal of Biomedicine and Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v2i1.35

Abstract

Background: The nephrotic syndrome (NS) resistance and relapse to treatment pose challenges in the management of NS. Several experimental studies on both animals and humans have assessed the association between NS and the balance between the oxidants and anti-oxidants. The study aims to compare the status of oxidants and anti-oxidants of NS patients between the massive proteinuria, the remission, the steroid resistance and the control groups. Methods: a cross-sectional design to assess the status of oxidants and antioxidants in children with the nephrotic syndrome. The eligible subjects were divided into four groups, the massive proteinuria group, the remission group, the steroid resistant group and the control group. The status of oxidants and anti-oxidant were evaluated with the Malondialdehyde (MDA) and the Total Antioxidant Status (TAS), respectively. Results: The highest mean MDA levels was observed in the steroid resistant group followed by the massive proteinuria group and the remission group. The mean MDA level of the proteinuria group (massive proteinuria and steroid-resistant) is higher than the remission group. The mean TAS levels in the remission group were higher than the massive proteinuria group, but the difference was not statistically significant. Moreover, the mean difference of SAT between the proteinuria group and without proteinuria was not statistically significant. Conclusions: The oxidative stress marker (MDA) was higher in the NS patients with proteinuria than the patients without proteinuria. The difference in the total anti-oxidant status in NS patients with massive proteinuria, remission and steroid resistance were not statistically significant. Keywords: Nephrotic syndrome, oxidative stress, anti oxidant
The Status of Oxidants and Antioxidants in Children with Nephrotic Syndrome Hertanti Indah Lestari; Eka Febri Zulissetiana; Ardesy Melizah
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 2 No. 1 (2018): Bioscientia Medicina: Journal of Biomedicine and Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v2i1.35

Abstract

Background: The nephrotic syndrome (NS) resistance and relapse to treatment pose challenges in the management of NS. Several experimental studies on both animals and humans have assessed the association between NS and the balance between the oxidants and anti-oxidants. The study aims to compare the status of oxidants and anti-oxidants of NS patients between the massive proteinuria, the remission, the steroid resistance and the control groups. Methods: a cross-sectional design to assess the status of oxidants and antioxidants in children with the nephrotic syndrome. The eligible subjects were divided into four groups, the massive proteinuria group, the remission group, the steroid resistant group and the control group. The status of oxidants and anti-oxidant were evaluated with the Malondialdehyde (MDA) and the Total Antioxidant Status (TAS), respectively. Results: The highest mean MDA levels was observed in the steroid resistant group followed by the massive proteinuria group and the remission group. The mean MDA level of the proteinuria group (massive proteinuria and steroid-resistant) is higher than the remission group. The mean TAS levels in the remission group were higher than the massive proteinuria group, but the difference was not statistically significant. Moreover, the mean difference of SAT between the proteinuria group and without proteinuria was not statistically significant. Conclusions: The oxidative stress marker (MDA) was higher in the NS patients with proteinuria than the patients without proteinuria. The difference in the total anti-oxidant status in NS patients with massive proteinuria, remission and steroid resistance were not statistically significant. Keywords: Nephrotic syndrome, oxidative stress, anti oxidant
ONLINE HEALTH CONSULTATION PLATFORM DURING THE COVID-19 PANDEMIC Budi Santoso; Siti Fazzaura Putri Sarahdeaz; Hertanti Indah Lestari; Yudhie Tanta
Conferences of Medical Sciences Dies Natalis Vol. 3 No. 1 (2021): Conference of Medical Sciences Dies Natalis Faculty of Medicine Universitas Sri
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (348.735 KB)

Abstract

Indonesia is currently experiencing the second wave of the Covid-19 pandemic. The Coronavirus is currently spreading faster with a higher severity, causing an increase in Covid-19 cases in the UNSRI Medical Faculty. There were 73 students and 13 lecturers and/or educators who were confirmed to have Covid-19 as of July 14, 2021, who had been recorded since early July. The increase in the number of confirmed cases of Covid-19 in students and lecturers causes the teaching and learning process to be suboptimal. . In addition, the increasing number of Covid-19 in the community while access to hospitalization is reduced, causing many people to need to self-isolate at home, who need a consultation about their health.The need for online health services is currently increasing as well where the Covid-19 number is currently at its peak. Many people need self-isolation at home because hospitals lack treatment facilities. Online health services are needed by people who find it difficult to consult directly with health facilities.The Faculty of Medicine, Sriwijaya University (FK Unsri), especially the lecturers who are also health workers, initiated the formation of the Online Doctor Chat (CDO), as a response to the Covid-19 pandemic situation
Co-Authors Aditiawati Aditiawati Ardesy Melizah Budi Santoso Eka Febri Zulissetiana Eka Intan Fitriania Minerva Riani Kadir Partini Pudjiastuti Trihono Putri, Sarahdeaz Siti Fazzaura Yudhie Tanta