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All Journal Sari Pediatri Bioscientia Medicina : Journal of Biomedicine and Translational Research Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Ilmu Kesehatan Indonesia (JIKSI)
Muhammad Hidayat
Bagian Ilmu Kesehatan Mata Fakultas Kedokteran Universitas Andalas/RSUP Dr. M. Djamil, Padang
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Hubungan Riwayat Keluarga, Berat Bayi Lahir, Usia Gestasi, dan Riwayat Konsumsi Susu Formula dengan Penyakit Refluks Gastroesofagus pada Bayi Usia 3 Minggu – 12 Bulan Puthisari Zonya Jannata; Yusri Dianne Jurnalis; Muhammad Hidayat
Sari Pediatri Vol 23, No 3 (2021)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/sp23.3.2021.178-84

Abstract

Latar belakang. Penyakit Refluks Gastroesofagus (PRGE) merupakan kondisi isi lambung kembali ke esofagus atau orofaring kemudian menimbulkan gejala dan/atau komplikasi pada bayi. Patofisiologi PRGE tidak terlepas dari adanya berbagai faktor risiko pada bayi, seperti riwayat keluarga dengan PRGE, berat bayi lahir, usia gestasi, dan riwayat konsumsi susu formula.Tujuan. Mengetahui hubungan riwayat keluarga PRGE, berat bayi lahir, usia gestasi, dan riwayat konsumsi susu formula dengan PRGE pada bayi usia 3 minggu – 12 bulan di Puskesmas Andalas.Metode. Studi potong lintang dilakukan pada Februari-Maret 2021 terhadap 82 bayi usia 3 minggu – 12bulan di Puskesmas Andalas, Padang. Data didapatkan dengan wawancara orang tua bayi menggunakan kuesioner PRGE IDAI dan kuesioner GERD-Q yang sebelumnya sudah menandatangi lembar persetujuan orang tua. Hasil. Bayi usia 3 minggu-6 bulan dan berjenis kelamin laki-laki paling banyak didapat PRGE. Hasil uji chi-square didapatkan riwayat keluarga PRGE (p=0,455), berat bayi lahir (p=0,029), usia gestasi (p=0,022), dan riwayat konsumsi susu formula (p=0,033) Hasil analisis regresi logistik didapatkan riwayat konsumsi susu formula menjadi faktor paling dominan dengan kejadian PRGE pada bayi dengan OR=3,210. Kesimpulan. Terdapat hubungan yang bermakna antara berat bayi lahir, usia gestasi, dan riwayat konsumsi susu formula dengan kejadian PRGE pada bayi.
Gambaran Sensitivitas Bakteri Penghasil Enzim Esbl terhadap Beberapa Antimikroba di RSUP Dr. M. Djamil Padang Periode 2018-2019 Muhamad Fadil; Roslaili Rasyid; Muhammad Hidayat
Jurnal Ilmu Kesehatan Indonesia Vol 2 No 2 (2021): Juni 2021
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (506.553 KB) | DOI: 10.25077/jikesi.v2i2.448

Abstract

Latar Belakang. Extended spectrum beta-lactamase (ESBL) adalah enzim yang diproduksi oleh bakteri tertentu yang mampu menghidrolisis penisilin, sefalosporin generasi 1,2,3 dan aztreonam. Antimikroba golongan beta-laktam merupakan salah satu antimikroba yang paling sering diresepkan. Resistansi yang disebabkan oleh enzim ESBL berakibat cukup signifikan terhadap pengobatan penyakit infeksi. Bakteri penghasil ESBL juga sering menunjukkan resistansi pada obat lain. Objektif. Untuk mengetahui gambaran sensitivitas bakteri penghasil enzim ESBL terhadap beberapa antimikroba di RSUP dr. M. Djamil Padang pada periode 2018-2019. Metode. Penelitian ini merupakan penelitian deskriptif dengan pendekatan retrospektif pada hasil uji sensitivitas bakteri penghasil enzim ESBL terhadap beberapa antimikroba menggunakan alat VITEK-2 yang diidentifikasi dari spesimen pasien di RSUP dr. M. Djamil Padang periode 2018-2019. Teknik pengambilan sampel dalam penelitian ini adalah total sampling menggunakan data hasil uji sensitivitas bakteri menggunakan alat VITEK-2. Hasil. Hasil penelitin ini ditemukan 2,855 bakteri penghasil enzim ESBL. Prevalensi terbanyak adalah Klebsiella sp dengan total 974 bakteri (34.1%), diikuti oleh E.coli dengan total 636 bakteri (22.3%) dan Acinetobacter sp dengan total 627 bakteri (22%). Setiap bakteri memiliki gambaran sensitivitas berbeda terhadap beberapa obat antimikroba. Obat-obat yang memiliki sensitivitas yang masih baik adalah karbapenem, amikasin, tigesiklin dan kombinasi β-laktam/β-laktamase inhibitor namun sudah mengalami penurunan sensitivitas pada bakteri grup tertentu. Pada bakteri grup falavobacterium hanya menunjukan sensitivitas yang baik terhadap obat siprofloksasin. Kesimpulan. Obat-obat yang memiliki sensitivitas yang masih baik adalah karbapenem, amikasin, tigesiklin dan kombinasi β-laktam/β-laktamase inhibitor. Background. Extended spectrum beta-lactamases (ESBLs) are defined as enzymes produced by certain bacteria that are able to hydrolyze penicillins, cephalosporins and aztreonam. The beta-lactam antimicrobials are one of the most commonly prescribed antimicrobials. The resistance caused by Extended spectrum beta-lactamases enzyme has a significant effect on the treatment of infectious diseases. ESBL-producing bacteria also frequently show resistance to other drugs. Objective. To describe the sensitivity of ESBL producing bacteria to several antimicrobials in dr. M. Djamil hospital Padang on 2018-2019. Methods. This research was a descriptive study with a retrospective approach in the results of the sensitivity test of ESBL producing bacteria to several antimicrobials using the VITEK-2 tool that was identified from patient specimens at dr. M. Djamil hospital Padang on 2018-2019. The samples were taken using total sampling technique uses the test results of bacterial sensitivity data using the VITEK-2 tool. Results. The results of this research found 2,855 ESBL producing bacteria. The highest prevalence was Klebsiella sp with a total of 974 bacteria (34.1%), followed by E. coli with a total of 636 bacteria (22.3%) and Acinetobacter sp with a total of 627 bacteria (22%). Each bacterium has a different pattern of sensitivity to several antimicrobial drugs. Drugs that have good sensitivity are carbapenem, amikacin, tigecycline and a combination of β-lactam / β-lactamase inhibitors but have decreased sensitivity in certain groups of bacteria. The falavobacterium group bacteria only showed good sensitivity to the ciprofloxacin. Conclusion. Drugs that have good sensitivity are carbapenem, amikacin, tigecycline and a combination of β-lactam / β-lactamase inhibitors.
Preventive Effects of Vitamin C on Cataracts: In Vivo Study Andri Yosrizal; Rinda Wati; Muhammad Hidayat
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 11 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i11.608

Abstract

Background: A cataract is a disease caused by various factors, one of which is the aging process. With increasing age, the formation of free radicals will cause pathological reactions in the lens and other toxic compounds, resulting in oxidative reactions. Administration of vitamin C injection as an antioxidant can reduce the reactivity of free radicals caused by oxidative reactions in cataract lenses induced by sodium selenite. This study aims to determine the preventive effect of vitamin C administration on selenite-induced cataracts based on the value of malondialdehyde (MDA) levels. Methods: The experimental study used 30 rats which were then divided into 5 treatment groups (P1, P2, P3, P4, and P5). Lenses were extracted for the measurement of malondialdehyde. The value of MDA levels was then analyzed using the One-way ANOVA statistical test. Results: Statistically, there was no significant difference in MDA levels in each treatment group. Analysis of the difference in mean MDA between the 2 groups showed that the average MDA levels of mice in groups P4 and P5 were relatively lower than P2 and P3, but higher than P1. Conclusion: Giving vitamin C was able to reduce MDA levels (a marker of oxidative stress) better than the group that did not receive vitamin C, but not statistically different.
The Effect of Topical Glutathione on Malondialdehyde Levels in Rat with Cataract-Induced Sodium Selenite Oknita Lasmaini; Muhammad Hidayat; Rinda Wati
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 6 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i6.829

Abstract

Background: Oxidative damage plays a key role in the lens opacity process. Reducing glutathione (GSH) is a tripeptide protein capable of preventing the accumulation of dangerous levels of oxidation products such as hydrogen peroxide and protein disulfide bonds. Human cataract lenses contain reduced levels of reduced glutathione, so by maintaining high levels of reduced glutathione in vivo, it may be possible to prevent opacification of the lens. This study aimed to determine the effect of topical glutathione on sodium selenite-induced cataracts based on the MDA level of the rat lens. Methods: This was an experimental study using 30 rats grouped into 3 groups (K+, P1, and P2). At the end of the study, the lens was dripped with Mydriaticum, then assessed for lens opacity. The more opacity lens was extracted, and subsequently, malondialdehyde level was measured. MDA level was analyzed using the One Way ANOVA test. Results: The average values of rat MDA Lens levels in the K+, P1, and P2 groups were 1.91, 1.38, and 1.2 nmol/mL. Statistically, there was a significant difference in MDA levels in each treatment group with p = 0.001 (p <0.05). Analysis of the average difference in MDA between each group showed that the average MDA level of rats in the P2 group was lower than P1, the MDA levels in the P1 and P2 groups were lower than K+, and there were statistically and clinically significant differences. Conclusion: Topical glutathione can effectively reduce the progression of cataracts in the lens of rats induced by sodium selenite which is identical to senile cataracts in humans in its mechanism of oxidative stress.
Clinical Insights into Internuclear Ophthalmoplegia: A Case Report Muhammad Fadhil Rahmadiansyah; Muhammad Hidayat
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 11 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i11.891

Abstract

Background: Internuclear ophthalmoplegia (INO) is a rare neuro-ophthalmological disorder characterized by impaired horizontal eye movement coordination due to lesion in the medial longitudinal fasciculus. INO commonly results from demyelinating diseases, vascular lesions, or structural brain abnormalities. Case presentation: A 60-year-old male patient presented with diplopia for the past 4 days. He had history of hypertension and diabetes mellitus and “mild” stroke for past years. Clinical examination revealed normal primary gaze, limited medial movement of the left eye, and diplopia in all gaze positions. Hess screen examination demonstrated underaction of the left medial rectus muscle and overaction of the right lateral rectus muscle. The laboratory results an elevated blood sugar level. Brain CT scan revealed multiple infarcts in the right parietal and cerebellar lobes and left parieto-occipital lobe, with evidence of brain atrophy. The patient was diagnosed with INO. Management involved addressing the underlying systemic diseases, namely diabetes and hypertension, in collaboration with internist and neurologist. The patient also received citicoline therapy and underwent regular follow-up. In the third-month follow-up, the patient demonstrated significant improvement, with reduction in diplopia and enhancement in left eye medial movement. Conclusion: This case report highlights the importance of considering INO in patients presenting with diplopia and a history of vascular risk factors. Timely diagnosis and comprehensive management with regular follow-up is crucial to monitor the progress and enhance the patient's quality of life.
Co-Authors Andri Yosrizal Muhamad Fadil Muhammad Fadhil Rahmadiansyah Oknita Lasmaini Puthisari Zonya Jannata Rinda Wati Rinda Wati Roslaili Rasyid Yusri Dianne Jurnalis