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All Journal Jurnal Matematika & Sains
Mohammad Mostaqul Huq
Graduate School of Pharmaceutical Sciences, Osaka University, Osaka
Mathematics

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Photoaffinity Labeling Study for Identification of the Target Protein of Antimalarial Isoquercitrin Syamsurizal Syamsurizal; Satoru Tamura; Mohammad Mostaqul Huq; Masafumi Kaneko; Nobutoshi Murakami
Jurnal Matematika & Sains Vol 12, No 2 (2007)
Publisher : Institut Teknologi Bandung

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Abstract

Isoquercitrin (1), a flavonol monoglycoside showed a strong antimalarial activity. In order to identify the target protein in Plasmodium falciparum, a photoreactive isoquercitrin analog, 2-[2-[2-(biotinylaminoethoxy) ethoxy]-4-[3-(trifluoromethyl)-3H-diazirin-3-yl] benzoic acid isoquercitrinyl ester (2) has been synthesized which closely mimics the action of 1. Photoaffinity labeling of 2 revealed the apparent molecular mass of ca 70 kDa on the uninfected erythrocyte membrane.
Co-Authors Masafumi Kaneko Nobutoshi Murakami Satoru Tamura Syamsurizal - -