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All Journal Nusantara Medical Science Journal Proceeding of Mulawarman Pharmaceuticals Conferences
Rosany Tayeb
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Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience

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The protective effect of Paliasa (Kleinhovia hospita L.) leaf extract against elevated total bilirubin serum induced by toxic dose of antituberculosis in rats Yulia Yusrini Djabir; Imelda Dhea Meylin; Rosany Tayeb
Nusantara Medical Science Journal Volume 4 No. 2 Juli - Desember 2019
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.v4i2.6474

Abstract

Liver dysfunction is implicated with the use of Antituberculosis (AT) leading to low compliance of TB patients to AT regimen. One of biomarker that is important to measure liver dysfunction is total bilirubin serum. Paliasa leaves have been emiprically used to improve liver function in South Sulawesi. This study aimed to determine the effect of ethanolic extract of Paliasa leaves on total bilirubin serum in rats. Twenty rats were devided into five groups: Group I served as the healthy control was only given NaCMC suspension, group II was treated with 178 mg/200gBB of AT suspension, while group III, group IV and group V  were given Paliasa extract 125 mg/kgBB, 250mg/kgBB and 500 mg/kgBB, respectively, 4 hours prior to AT suspension administration. Treatments were performed once a day for 28 days. Blood sampling was carried out 24 hours following the last treatment. The total bilirubin levels were measured using Humalyzer 3500. The results showed that the administrations of AT suspension for 28 days significantly increased rat total bilirubin levels. Paliasa leaf extract in all given dose was able to reduce the total bilirubin levels of rats compared to the group given only AT suspension. However, statistical significance was only reached by the groups that were treated with Paliasa extract 250 and 500 mg/kgBB. Therefore it is concluded that ethanol extract at a dose of 250 and 500 mg/kgBB has protective effect against AT-induced elevation of total bilirubin serum in rats.
Uji Efek Pemberian Ekstrak Etanol Daun Sirsak (Anonna muricata L.) terhadap Kadar Asam Urat pada Tikus Putih (Rattus norvegicus) Rosany Tayeb; Mience Ubyaan; Usmar Usmar
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 3 (2016): Spesial Issue of Mulawarman Pharmaceuticals Conference Proceeding (Prosiding Semnas T
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (196.766 KB) | DOI: 10.25026/mpc.v3i2.135

Abstract

Telah dilakukan penelitian tentang uji efek pemberian ekstrak etanol daun sirsak (Anonna muricata L.) terhadap kadar asam urat pada tikus putih (Rattus norvegicus). Penelitian ini bertujuan untuk mengetahui efek pemberian ekstrak etanol daun sirsak pada tikus putih. Tikus yang digunakan sebanyak 15 ekor yang dibagi menjadi 5 kelompok. Kelompok I sebagai kontrol negatif diberi larutan koloidal NaCMC 1% b/v, kelompok II, III, dan IV merupakan kelompok perlakukan masing-masing diberi ekstrak etanol daun sirsak 1%, 2%, 4% b/v dan kelompok V sebagai kontrol positif diberikan suspensi allopurinol 1,8 mg/200 g BB. Masing-masing kelompok diinduksi hiperurisemia dengan kalium bromat (KbrO3) 111 mg/100 g BB dan dibiarkan selama 30 menit, kemudian dilakukan pengambilan darah setelah 1 jam dan 3 jam perlakuan. Analisis statistik dengan RAL (Rancangan Acak Lengkap) yang dilanjutkan dengan uji Beda Nyata Jarak Duncan (BJND), menunjukan bahwa ekstrak etanol daun sirsak dengan konsentrasi tertinggi yang diberikan (4%) memberikan efek terbesar, tetapi masih lebih kecil secara sangat signifikan dibandingkan dengan kontrol positif (Allopurinol).
Co-Authors Imelda Dhea Meylin Mience Ubyaan Usmar Usmar Yulia Yusrini Djabir