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All Journal Indonesian Journal of Biotechnology Jurnal Manajemen Dayasaing Jurnal Penelitian Pertanian Terapan Jurnal Ilmiah Cendekia Eksakta Prosiding University Research Colloquium Journal Research Midwifery Politeknik Tegal
Siti Nur Chasanah
Departemen Biokimia Fakultas Kedokteran Universitas Wahid Hasyim
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Decision Sciences, Operations Research & Management Environmental Science Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Nursing Public Health Social Sciences

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MicroRNA-21 as a biomarker for ovarian cancer detection Aprilia Indra Kartika; Siti Nur Chasanah; Akbar Satria Fitriawan; Dewi Sahfitri Tanjung; Addin Trirahmanto; Heru Pradjatmo; Teguh Aryandono; Sofia Mubarika Haryana
Indonesian Journal of Biotechnology Vol 23, No 1 (2018)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (120.369 KB) | DOI: 10.22146/ijbiotech.35692

Abstract

Ovarian cancer is a lethal disease. One of the problems faced by patients with ovarian cancer is the lack of symptoms in its early stages, which results in it only being detected when it is at an advanced stage. Therefore, there is an urgent need for biomarkers that can predict ovarian cancer precisely. The purpose of this study was to determine the expression of microRNA-21 as a predictive biomarker candidate in both early- and advanced-stage ovarian cancer. This was a cross-sectional study using the blood plasma of 21 healthy control subjects and 37 blood plasma samples from patients with ovarian cancer. Blood plasmas were collected, from which the RNA was isolated. Based on the RNA, the cDNA was synthesized and run through qPCR, the results of which were analyzed using the Livak method. The results showed an upregulation of microRNA-21 in the advanced stage by 2.14 fold compared with the early stage, and 6.13 fold compared with the healthy controls (p < 0.05). The upregulation of microRNA-21 in early-stage ovarian cancer was 2.86 fold compared with the healthy control subjects (p < 0.05). In addition, there was an increase in the expression of microRNA-21 in ovarian cancer by 4.14 fold compared with the healthy controls (p < 0.05). Based on these results, it can be concluded that the expression of microRNA 21 upregulated with the severity of the disease.
PENGARUH KOMITMEN ORGANISASI, ORIENTASI BERP RESTASI DAN EFFORT PADA KINERJA JABATAN DAN KEPUASAN KERJA Siti Nurchasanah,; Triyono Triyono; Ahmad Mardalis
Jurnal Manajemen Dayasaing Vol 16, No 2 (2014): Jurnal Manajemen Daya Saing
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/dayasaing.v16i2.2051

Abstract

The objective of this study is to analyze the influence of organizational commitment, achievement orientation and effort on job performance and job satisfaction. The total sample of 80 employees of PT Perkebunan Nusantara V (Persero) with purposive sampling. Based on the data analysis can be concluded that organizational commitment influences the job performance, as well as achievement orientation, achievement orientation influences the job performance. Meanwhile, the Effort does not have significantly on the job performance. This is because at that time of the study of human resource management system associated with the consequence of Effort which has not been implemented. This condition is also influenced by individual effort which has not reflected the effort from all job performances, remembering job performance results obtained from group performance subvention. Organizational commitment significantly has greater significantly on job performance than achievement orientation. This study also found that job performance has influence on job satisfaction and job satisfaction has influence on organizational commitment.
RESPONS PADI INPARI TERHADAP MUTAGEN SODIUM AZIDE Yugi R Ahadiyat; Armida Triani; Siti Nurchasanah
Jurnal Penelitian Pertanian Terapan Vol 21 No 1 (2021)
Publisher : Politeknik Negeri Lampung.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25181/jppt.v21i1.1996

Abstract

The objective of this study was to study the response of rice cv. Inpari to soaking time in sodium azide mutagen in terms of sensitivity, seedling performance, and genetic distance based on morphological characters. An experiment was conducted using a split-plot design with rice variety (Inpari 31, 32, and 33) as the main plot, and the soaking time in sodium azide (0, 5, 10, 15, and 20 hours) as the subplot. The result showed that Inpari 32 had more sensitivity, and higher germination and seedling growth performance compared to Inpari 31 and 33. The closest phylogenetic relationship occurred between Inpari 31 and 33 without mutagen, and between inpari 32 and 33 with a soaking time of sodium azide 10 and 20 hours
KADAR SERUM GLUTAMIC PYRUVATE TRANSAMINASE DARAH TIKUS (Rattus norvegicus Berkenhout, 1769) HIPERLIPIDEMIA DENGAN ASUPAN PELET NASI DAN BEKATUL BERAS HITAM PADI (Oryza sativa L.) “CEMPO IRENG” Siti Nur Chasanah; Rarastoeti Pratiwi
CENDEKIA EKSAKTA Vol 4, No 1 (2019)
Publisher : Universitas Wahid Hasyim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.3194/ce.v4i1.2672

Abstract

Diet makanan tinggi lemak jenuh dan tinggi kolesterol dapat meningkatkan resiko terjadinya kondisi hiperlipidemia. Penelitian sebelumnya, menunjukkan bahwa beras merah dan hitam mengandung antioksidan yang lebih tinggi dibandingkan beras putih. Beras hitam efektif dalam memperbaiki fungsi hati tikus yang mengalami hiperlipidemia. Penelitian ini bertujuan untuk mengetahui kadarSerum Glutamic Pyruvate Transaminase (SGPT) pada tikus hiperlipidemia dengan perlakuan diet nasi hitam dan bekatul beras hitam yang berasal dari padi hitam “Cempo Ireng”. Sebanyak 24 ekor tikus putih jantan yang dibagi menjadi 4 kelompok yaitu kelompok kontrol normal dan 3 kelompok hiperlipidemia yang masing-masing kelompok diberi diet pelet pakan basal, pelet mengandung 30% nasi hitam dan pelet mengandung 10% bekatul beras hitam. Tahap pertama adalah induksi hiperlipidemia pada kelompok hiperlipidemia dengan pemberian campuran minyak babi dan kuning telur bebek dengan perbandingan 1:1 (v/v) yang dicampur dengan kolesterol murni 2%. Dosis yang diberikan sebanyak 1 ml/100 g BB secara peroral setiap hari selama 30 hari. Tahap kedua adalah perlakuan diet pakan selama 30 hari dengan tetap mempertahankan kondisi hiperlipidemia. Berat badan tikus ditimbang setiap 7 hari dan sisa konsumsi pakan ditimbang setiap hari. Pengukuran kadar SGPT dilakukan setelah perlakuan hiperlipidemia dan perlakuan diet pakan. Hasil pengukuran kadar SGPT dianalisis menggunakan one way ANOVA dilanjutkan uji Tukey’s HSD dan uji T-Test dengan signifikansi 5%. Hasil analisis menunjukan bahwa saat perlakuan hiperlipidemia disertai pakan mengandung 30% nasi hitam mampu menurunkan kadar SGPT sebanyak 19,38%. Pada perlakuan hiperlipidemia disertai pakan pelet mengandung 10% bekatul beras hitam mampu menurunkan kadar SGPT sebanyak 21,46%. Secara statistik penurunan ini signifikan (<0,05), sehingga dapat disimpulkan bahwa bekatul beras hitam lebih efektif dari pada nasi hitam dalam memperbaiki fungsi hati berdasarkan penurunan kadar SGPT pada tikus hiperlipidemia. Kata kunci: SGPT, hiperlipidemia, beras hitam, bekatul 
PERBEDAAN EFEK RELAKSASISTRETCHING DAN AROMATERAPI TERHADAP KELUHAN NYERI KEPALA PRIMERKARYAWAN PT X Dian Inayati; Ari Suwondo; Baju Widjasena; Siti Nur Chasanah
CENDEKIA EKSAKTA Vol 3, No 2 (2018)
Publisher : Universitas Wahid Hasyim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.3194/ce.v3i2.2477

Abstract

Nyeri kepala primer merupakan keluhanyang sering dikeluhkan oleh pasien yang datang berobat di klinik perusahaan.Hal ini berakibat menurunkan produktifitas dan meningkatkan losstime juga penambahan anggaran biaya kesehatan perusahaan. Terapi Relaksasi 60% dapat mengurangi nyeri kepala primer. Aromaterapi dan stretching contoh dari terapi relaksasi tersebut. Penelitian ini bertujuan untuk mengetahui perbedaan efek relaksasi stretching dan aromaterapi terhadap keluhan nyeri kepala serta membuktikan apakah kortisol dapat dipakai sebagai penanda nyeri kepala primer.Penelitian dilakukan dengan menggunakan metode quasi eksperimen dengan  times series design pada 30 sampel dengan menggunakan teknik non probability sampling menggunakan metode purposive sampling. Subyek dibagi dalam dua kelompok,yaitu 15 orang responden dalam kelompok stretchingdan 15 orang responden masuk kelompok aromaterapi.Nyeri kepala sebelum dan sesudah terapi aromaterapi nilai p sebesar 0,001 (p<0,05) dapat disimpulkan terdapat perbedaan signifikan antara VAS sebelum dan setelah terapi Aromaterapi. Pada perlakuan terapi streching didapat nilai p sebesar 0,00 (p<0,05) dapat disimpulkan terdapat perbedaan signifikan antara VAS sebelum dan setelah terapi Streching.Uji korelasi spearman’s kadar kortisol terhadap VAS (penanda nyeri) didapat nilai p 0,458 dimana p> 0,05 hasilnya tidak signifikan. Penelitian ini memperlihatkan hasil bahwa stretching dan aromaterapi sama-sama berpengaruh terhadap keluhan nyeri kepala primer. Kortisol tidak bisa digunakan sebagai penanda nyeri kepala primer. Kata kunci : aromaterapi, kortisol, nyeri kepala primer, stretching
PENGARUH PEMBELAJARAN SAS DENGAN MEDIA PAFLACA TERHADAP KEMAMPUAN MEMBACA PERMULAAN Siti Nur Chasanah; Rasidi Rasidi; Putri Meinita Triana
Prosiding University Research Colloquium Proceeding of The 14th University Research Colloquium 2021: Bidang Pendidikan
Publisher : Konsorsium Lembaga Penelitian dan Pengabdian kepada Masyarakat Perguruan Tinggi Muhammadiyah 'Aisyiyah (PTMA) Koordinator Wilayah Jawa Tengah - DIY

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (326.421 KB)

Abstract

This research aims to know the influence of learning SAS with the media Paflaca to theability to read the beginning of the 1st grade students of primary School in the Village of Tegalarum. This research is an experimental research on the design of the Pre-Experimental Design type of One-Group Pretest-posttest. This research was conducted in the Village of Tegalarum Kecamatan Borobudur, Magelang Regency. Before carrying outresearch in the village the researchers conducted observations of the pre-study onstudent Elementary school class I found the problem is reading the beginning of the stilllow. The subject of this research is the students of class I in the Village of Tegalarumwhich amounted to 16 students, which consisted of 10 female students and 6 malestudents. Data collection using the method of the test. This test is used before and after agiven treatment and the analysis used in this research is the Wilcoxon Signed Rank Testwith programSPSS version of 25.00. This research was conducted in the month of July2021. The results showed that the method of learning SAS-assisted media Paflaca affectthe ability to read the beginning. Evidence of improved student learning outcomes,namely the presence of a significant difference between the value of pretest and the valueof the posttest, namely the average value of pretest 58,1 while the average value ofposttest were 79.1 and the results of the Wilcoxon Signed Rank Test obtained value (2-tailed)-3,551 with a significance value of 0.000.
GAMBARAN PERILAKU IBU NIFAS DALAM PERAWATAN LUKA PERINEUM DI KELURAHAN KABUPATEN BREBES Siti Nur Chasanah; Dedi Sutanto; Novia Ludha Arisanti
Siklus : Journal Research Midwifery Politeknik Tegal Vol 4, No 1 (2015)
Publisher : Pusat Penelitian dan Pengabdian Masyarakat Politeknik Harapan Bersama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30591/siklus.v4i1.244

Abstract

Perawatan perineum sangat penting dilakukan oleh ibu nifas yaitu dengan cara sering mengganti pembalut setiap kali habis BAB/BAK, kemudian basuh dengan air bersih dari arah depan belakang, membersihkan luka pada perineum dengan menggunakan sabun atau cairan antiseptic lainnya. Penelitian ini bertujuan untuk mengetahui perilaku ibu nifas dalam perawatan luka perineum di Kelurahan Brebes Kabupaten Brebes. Rancangan dan jenis penelitian ini adalah survey deskriftif dan cross sectional, jenis data ada 2 yaitu data primer dan data sekunder, data primer dikumpulkan melalui pengisian kuesioner serta data sekunder dengan kajian terhadap sumber atau refrensi yang relevan, sedangkan variabel penelitian ini adalah perilaku, jumlah sampel yang digunakan adalah 40 responden yang mengalami luka jahitan. Perilaku perawatan luka perineum yang banyak dilakukan yaitu pada perilaku membersihkan daerah kelamin setiap kali selesai buang air besar sebanyak 40 responden (100%). Perilaku perawatan luka perineum yang paling jarang dilakukan yaitu pada perilaku mencuci tangan dengan air dan sabun sebelum membersihkan daerah kelaminnya sebanyak 35 responden (87,5%) Kesimpulan dari dilakukannya penelitian ini didapatkan hasil, masih banyak ibu nifas yang melakukan perawatan luka perineum yang salah. Kata kunci : perilaku, perawatan luka perineum pada ibu nifas
Co-Authors Addin Trirahmanto AHADIYAT YUGI R. Ahmad Mardalis, Ahmad Akbar Satria Fitriawan Aprilia Indra Kartika Ari Suwondo Armida Triani Baju Widjasena Dedi Sutanto Dewi Sahfitri Tanjung Dian Inayati Heru Pradjatmo Novia Ludha Arisanti Putri Meinita Triana Rarastoeti Pratiwi Rasidi Rasidi Sofia Mubarika Haryana Teguh Aryandono Triyono Triyono