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Jannatus Salis Sa'diyah
Universitas Muhammadiyah Surakarta
Dentistry Health Professions

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Pengaruh gel ekstrak daun binahong (Anredera cordifolia) konsentrasi 5% terhadap re-epitelisasi luka pasca pencabutan gigi tikus putih Wistar (Rattus norvegicus)The effect of 5% binahong (Anredera cordifolia) leaf extract gel on wounds re-epithelialization after tooth extraction of white Wistar rats (Rattus norvegicus) Dewi Ayu Septiana; Jannatus Salis Sa'diyah; Nanda Nailul Farih; Juwita Raditya Ningsih
Jurnal Kedokteran Gigi Universitas Padjadjaran Vol 31, No 3 (2019): Desember 2019
Publisher : Fakultas Kedokteran Gigi Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/jkg.v31i3.21833

Abstract

Pendahuluan: Pencabutan gigi merupakan salah satu tindakan perawatan dalam bidang kedokteran gigi. Epitel gingiva yang rusak akibat proses pencabutan gigi akan mengalami proses penyembuhan yang disebut re-epitelisasi. Re-epitelisasi merupakan parameter penting dalam penyembuhan luka soket pasca pencabutan gigi. Penelitian sebelumnya menunjukkan bahwa daun binahong memiliki kandungan aktif seperti flavonoid, alkaloid, terpenoid, tanin, asam oleanolik, dan saponin, yang berperan dalam re-epitelisasi pasca pencabutan gigi tikus putih Wistar (Rattus norvegicus). Penelitian ini bertujuan untuk mengetahui adanya pengaruh gel ekstrak daun binahong (Anredera cordifolia) konsentrasi 5 % terhadap re-epitelisasi luka pasca pencabutan gigi tikus putih Wistar. Metode: Obyek penelitian berupa 45 ekor tikus dibagi menjadi 3 kelompok, yaitu kontrol negatif, kontrol positif, dan kelompok uji yang diberi gel ekstrak daun binahong. Gigi insisivus sentral kiri rahang bawah dicabut, kemudian masing-masing diberi CMC-Na 1% (kontrol negatif), iod gliserin (kontrol positif) dan gel ekstrak daun binahong konsentrasi 5% (kelompok perlakuan), selama 10 menit sehari sekali. Tikus diterminasi pada hari ke 3, 5, 7, 14, dan 21 pasca dilakukan pencabutan gigi, kemudian diambil rahang bawahnya untuk dibuat preparat histologis dengan pengecatan hematoksilin eosin. Ketebalan epitel diukur dengan Optilab dan software image raster. Hasil: Hasil uji one-way ANOVA menunjukkan terdapat perbedaan ketebalan epitel yang bermakna antar kelompok (p<0,05) pada masing-masing hari. Hasil uji Least Significant of Difference (LSD) menunjukkan perbedaan yang bermakna (p<0,05) pada hari ke-3, 5, 7, 14, dan 21 pasca pencabutan antara kelompok gel ekstrak daun binahong dibandingkan dengan kontrol negatif, serta pada hari ke-5, 14, dan 21 pasca pencabutan antara kelompok gel ekstrak daun binahong dibandingkan dengan kontrol positif. Simpulan: Pemberian gel ekstrak daun binahong (Anredera cordifolia) konsentrasi 5% memiliki pengaruh terhadap re-epitelisasi luka pasca pencabutan gigi tikus Wistar (Rattus norvegicus).Kata kunci: Gel ekstrak daun binahong, pencabutan gigi, re-epitelisasi. ABSTRACTIntroduction: Tooth extraction is one of the treatments in dentistry. The damaged gingival epithelium after tooth extraction will undergo a healing process called re-epithelialization. Re-epithelialization is an essential parameter in the healing wound process after tooth extraction. Previous studies have shown that binahong leaves have active ingredients such as flavonoids, alkaloids, terpenoids, tannins, oleanolic acids, and saponins, which play a role in re-epithelialization after the extraction of the teeth of white Wistar rats (Rattus norvegicus). This study was aimed to determine the effect of binahong (Anredera cordifolia) leaf extract gel with a concentration of 5% on wound re-epithelialization of wounds after tooth extraction of white Wistar rats. Methods: 45 white Wistar rats were divided into 3 groups, namely negative control, positive control, and the test groups which were administered with binahong leaf extract gel. The mandibular left central incisors were extracted, then applied with 1% CMC-Na (negative control), glycerin iodine (positive control), and 5% binahong leaf extract gel (treatment group), for 10 minutes once a day. All rats were terminated on the 3rd, 5th, 7th, 14th, and 21st day after tooth extraction. Then their lower jaw was taken to make histological preparations with hematoxylin eosin staining. Epithelial thickness was measured by Optilab and raster image software. Results: One-way ANOVA test results showed that there were significant differences in epithelial thickness among groups (p<0.05) on each day. The Least Significant of Difference (LSD) test results showed a significant difference (p<0.05) on the 3rd, 5th, 7th, 14th, and 21st day after extraction, between the binahong leaf extract gel groups compared with the negative control, and on the 5th, 14th, and 21st day after extraction, between binahong leaf extract gel group compared with the positive control. Conclusion: Administration of 5% binahong (Anredera cordifolia) leaf extract gel has an influence on the wound re-epithelialization after tooth extraction of white Wistar rats (Rattus norvegicus).Keywords: Binahong leaf extract gel, tooth extraction, re-epithelialization.
Pengaruh gel ekstrak daun binahong (Anredera cordifolia) 5% terhadap peningkatan osteoblas pada proses penyembuhan luka pasca pencabutan gigi tikus strain WistarEffect of 5% binahong (Anredera cordifolia) leaf extract in increasing the osteoblast amount at the tooth extraction wound healing process of Wistar rat Jannatus Salis Sa&#039;diyah; Dewi Ayu Septiana; Nanda Nailul Farih; Juwita Raditya Ningsih
Jurnal Kedokteran Gigi Universitas Padjadjaran Vol 32, No 1 (2020): April 2020
Publisher : Fakultas Kedokteran Gigi Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/jkg.v32i1.26885

Abstract

Pendahuluan: Pencabutan gigi di dunia kedokteran gigi adalah tindakan yang sering dilakukan. Pasca terjadinya pencabutan gigi, maka tulang pada soket akan rusak. Penyembuhan tulang ditandai dengan terbentuknya sel-sel osteoblas baru. Daun binahong merupakan daun yang mengandung flavonoid, alkaloid, terpenoid, asam askorbat, saponin, tanin dan asam oleanolik. Kandungan dari daun binahong dapat meningkatkan jumlah osteoblas pasca pencabutan gigi. Tujuan dari penelitian adalah menganalisis pengaruh pemberian gel ekstrak daun binahong (Anredera cordifolia) konsentrasi 5% terhadap peningkatan osteoblas pada proses penyembuhan luka pasca pencabutan gigi. Metode: Jenis penelitian ini merupakan penelitian eksperimental laboratorium murni dengan rancangan post test only control group design. Subyek penelitian berupa 45 ekor tikus dibagi menjadi 3 kelompok, yaitu kelompok gel ekstrak daun binahong, kontrol negatif dan kontrol positif. Gigi insisivus sentral kiri rahang bawah dilakukan pencabutan gigi kemudian diaplikasikan gel ekstrak daun binahong 5%, CMC-Na 1% dan iod gliserin. Tikus diterminasi pada hari ke 3,5,7,14 dan 21 pasca dilakukan pencabutan gigi untuk selanjutnya dibuat preparat histologis dengan pengecatan hematoksilin eosin. Jumlah sel osteoblas dihitung dengan optilab dan software image raster. Hasil: Hasil uji parametrik one way anova menunjukan terdapat perbedaan jumlah osteoblas yang bermakna antar kelompok (p<0,05) pada masing-masing hari. Hasil LSD (Least Significance Different) menunjukkan terdapat perbedaan yang bermakna (p<0,05) pada hari ke 5,7, 14 dan 21 antara kelompok perlakuan dengan kontrol negatif dan terdapat perbedaan yang bermakna pada hari ke 7 dan 14 antara kelompok perlakuan dan kontrol positif. Simpulan: Gel ekstrak daun binahong konsentrasi 5% berpengaruh dalam meningkatkan jumlah sel osteoblas pasca dilakukan pencabutan gigi.Kata kunci: Pencabutan gigi, gel ekstrak daun binahong, osteoblas. ABSTRACTIntroduction: Tooth extraction is the most common treatment in dentistry. After tooth extraction, the bone in the socket will be damaged. The formation of new osteoblast characterises bone healing. Binahong leaves contain flavonoids, alkaloids, terpenoids, ascorbic acid, saponins, tannins and oleanolic acids. This research was aimed to investigate the effectivity of binahong (Anredera cordifolia) leaf extract gel with a concentration of 5% in increasing the number of osteoblasts at the tooth extraction wound healing process. Methods: This research was an experimental laboratory with a post-test only control group design. Forty-five rats were divided into 3 groups; binahong leaf gel group, negative control group, and positive control group. Mandibular left central incisive was extracted, then binahong leaf gel, 1% CMC-Na, and glycerin were applied on the wound socket in different groups. All rats then terminated at day 3, 5, 7, 14, and 21 post-extraction and processed for the histological examination then coloured by haematoxylin-eosin. The number of osteoblasts was calculated by Optilab and raster image software. Results: The ANOVA test result showed significant differences in the number of osteoblasts among groups (p<0.05) on each day. The LSD (Least Significance Different) test result showed significant differences (p<0.05) at day 5, 7, 14, and 21 post-extraction, between binahong leaf gel group compared to the negative control group, and also at day 7 and 14 post-extraction between binahong leaf gel group compared to the positive control group. Conclusion: Binahong leaf extract gel with a concentration of 5% is effective in increasing the number of osteoblast in the wound healing process after tooth extraction.Keywords: Tooth extraction, Binahong leaf extract gel, osteoblast.
Co-Authors Dewi Ayu Septiana Juwita Raditya Ningsih Nanda Nailul Farih