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All Journal Jurnal Riset Veteriner Indonesia (Journal of The Indonesian Veterinary Research)
Amelia Ramadhani Anshar
Bogor Agriculture University
Agriculture, Biological Sciences & Forestry Veterinary

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The Effect of Avocado to the Profile of Blood Urea Nitrogen (BUN) and Creatinine in Rats (Rattus norvegicus) Induced with Meloxicam Amelia Ramadhani Anshar; Muhammad Akbar Bahar; Dini Kurnia Ikliptikawati
Jurnal Riset Veteriner Indonesia (Journal of The Indonesian Veterinary Research) VOLUME 2 NO. 1, JANUARY 2018
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/jrvi.v2i1.3802

Abstract

Incidence of drug overdose during treatment of acute disease consequently leads to serious renal damage. As supporting treatment, administration of herbal medicine and food dietary are frequently developed. This research aimed to prove how the administration of avocado juice could lower the BUN and creatinine level in white rats induced with toxic doses of meloxicam. Meloxicam is a non-steroidal anti-inflamatory drug (NSAID), which is effectively used as an anti-inflamatory, analgesic, and antipyretic. Twenty four (24) male Wistar rats were assigned to 4 groups of six rats each (n=6). 1 ml of CMC 1% was administered to Control Group I, 30 mg/kgBB meloxicam and 1 ml of CMC 1% to Control Grup II, 30 mg/kgBB meloxicam and avocado juice 5 g/kgBB/day to Treatment Group I, and 30 mg/kgBB meloxicam and avocado juice 10 g/kgBB/day to Treatment Group II. The study was conducted over 8 days, then the level of Blood Urea Nitrogen and creatinine of the white rats were examined on the 1st and 8th day. The results were analyzed by Anova Two Way With Replication, then followed by T-test (α = 0,05) if there were difference. The Anova Two Way With Replication test showed that the mean of the four groups either the levels of Blood Urea Nitrogen or creatinine was significantly decreased (p<0,05). The decrease of BUN in the treatment group I was 27,17 27,17mg/dl and 17,83mg/dl while the decrease of creatinine level was 0,983mg/dl and 0,713mg/dl. The conclusion of this study was that avocado juice decreases level of Blood Urea Nitrogen and creatinine in white rats which exposed toxic doses of meloxicam.
Correlation Analysis of Enverontmental Cd Exposure in Liver and Meat of Broiler Chicken Amelia Ramadhani Anshar; Huda Salahudin Darusman; Hera Maheshwari
Jurnal Riset Veteriner Indonesia (Journal of The Indonesian Veterinary Research) VOLUME 2 NO. 2, JULY 2018
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/jrvi.v2i2.4354

Abstract

Cadmium (Cd) belongs to heavy metal with high anthropogenic pollutant and non-essential to physiological funtion. Regular intake of consuming Cd leads to physiological disorders in poultry animal as well as humans as one who consume it. The aim of this study was to analyze the profile of Cd content in environmental samples (poultry feed and water) and it correlated with the degree of contamination in broiler tissues. In this study, 30 samples of feeds and water samples along with 60 samples of liver and muscle have been examined. The results showed that the feed was indicated to Cd between 0.009-0.202 mg / kg and in the water between 0.0068-0.0096 mg / l. Cd in the livers and muscles was then positively contaminated by Cd between 0.438-0.565 mg / kg and the levels was significantly different (p <0.05) among organs. A strong positive correlation was found between Cd and water levels in liver (r = 0.896). In contrast, a weaker positive correlation (r = 0.596) was found in the water and muscle. In conclusion, Cd contamination in feed and water correlated positively with the increasing amount of the cadmium level in organs.
The Nephroprotector Effect of Sukari Date (Phoenix dactylifera) Extract on Meloxicam Induced in Rats Amelia Ramadhani Anshar, B.VSc, M.Si; Muhammad Ardiansyah Nurdin; Rizky Widianty; Mutmainnah Zubakir; Andi Tenri Khofifah; Dwiyuci Fauziah
Jurnal Riset Veteriner Indonesia (Journal of The Indonesian Veterinary Research) VOLUME 6 No 2, JULY 2022
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/jrvi.v6i2.18623

Abstract

Drug poisoning in pets can cause serious kidney damage due to high levels of free radicals in body against the toxicity. Prevention of kidney damage can be solved by using of some exogenous antioxidants. Sukari dates (Phoenix dactylifera) are reported able to reduce off free radicals with antioxidant active ingredients in such as flavonoids, phenolics, vitamins C, A, E, and B-carotene. This study aims to determine the effect of Sukkari date extract as a nephroprotector agent in reducing blood urea nitrogen (BUN) levels after meloxicam induced. This experimental study with a completely randomized design used 24 male white rats of wistar strain which were divided into 4 treatment groups. Group 1 (K1) is a negative control group given 1% NaCMC, group 2 (K2) is a positive control group given 2 ml at a dose of 30 mg/kgBW meloxicam, treatment group 1 (P1) and treatment group 2 (P2) were each given 2 ml of Sukari date extract at a dose of 500 mg/kgBW and 1000 mg/kgBW for 11 days. Meloxicam induction dose of 30 mg/kgBW was given on the 12th day, BUN levels were measured on the 13th day and 15th day with a spectrophotometer. BUN concentration of mean in control groups K1 was 19.54±0.828, K2 group was 41.55±0.534, the treatment group P1 was 24.86±0.715 and P2 was 20.48±0.383. These results indicate that the administration of Sukari date extract was able to maintain BUN levels at normal levels even though they had been exposed to toxic doses of meloxicam. Keywords: Antioxidants, Blood Urea Nitrogen (BUN), Sukkari dates, meloxicam
Co-Authors Andi Tenri Khofifah Dwiyuci Fauziah HERA MAHESHWARI Huda Salahudin Darusman Ikliptikawati, Dini Kurnia Muh. Akbar Bahar Muhammad Ardiansyah Nurdin Mutmainnah Zubakir Rizky Widianty