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All Journal Bioscientia Medicina : Journal of Biomedicine and Translational Research Diponegoro International Medical Journal (DIMJ) Bioscientia Medicina : Journal of Biomedicine and Translational Research
Sindhu Nugroho Mukti
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Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience

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Sleeve Gastrectomy Improved TGF-β and IL-10 Expression in Obesity and Diabetes Mellitus Rats Mukti, Sindhu Nugroho; Prasetyo, Sigit Adi; Shobirin, Muhammad Ali; Rozy, Abdul Mughni; Prajoko, Yan Wisnu; Sagap, Ismail Bin
Diponegoro International Medical Journal Vol 5, No 2 (2024): December 2024
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v5i2.24232

Abstract

Introduction: Atherosclerosis is a cardiovascular disease which is the leading cause of 16% of the world's total deaths. The main comorbidities of atherosclerosis are obesity and diabetes mellitus. One of obesity surgery treatment that is currently very often used is the Sleeve Gastrectomy. Sleeve Gastrectomy is the most effective and significant long-term therapy for weight loss and preventing various comorbidities such as heart disease. This study analyze the effect of sleeve gastrectomy on the expression of atherosclerosis anti-inflammatory cytokines (TGF-β and IL-10) in the abdominal aorta on the process of atherosclerosis in obesity and diabetes mellitus subjects.Methods: An in vivo laboratory experimental study with post-test control group design on 15 male rats (Sprague Dawley) that was randomly divided into 3 groups: K1 (negative control), K2 (positive control with obesity and diabetes mellitus) and P1 (obese and DM rats treated with sleeve gastrectomy). After 10th day of the procedure, we analyze the body weight, fasting blood glucose, and gene expression of TGF-β and IL-10 using the PCR method. Statistical analysis was done using Anova, Kruskal Wallis and Post Hoc LSD.Results: There was significant decrease in body weight (p=0,000) and fasting blood sugar levels (p=0,000) in the P1 compared to the K2. There was significant increase of TGF-β (p = 0,005) and IL-10 (p = 0,002) gene expression in P1 compared to K1 and K2.Conclusion: SG decreased body weight and fasting blood sugar levels of obese and DM subjects. Also improved the expression of atherosclerosis anti-inflammatory cytokines (TGF-β and IL-10) in abdominal aorta.
The Pointed Challenge: Endoscopic Management of an Ingested Sharp Foreign Body and a Synthesis of Modern Techniques Sindhu Nugroho Mukti; Sigit Adi Prasetyo; Bernardus Parish Budiono
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 12 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i12.1465

Abstract

Background: The ingestion of sharp-pointed foreign bodies constitutes a high-acuity medical emergency, distinguished from other ingested objects by its significant potential for severe complications, including visceral perforation and hemorrhage. While flexible endoscopy has emerged as the cornerstone of management, its successful application hinges on a systematic, protocol-driven approach. This manuscript presents a case of an ingested straight pin and uses it as the framework for a critical synthesis of modern diagnostic and therapeutic strategies. Case presentation: A 40-year-old female presented to the emergency department, hemodynamically stable and completely asymptomatic, two hours after accidentally swallowing a straight pin. A benign abdominal examination belied the potential danger. Plain radiography confirmed a single, sharp metallic object in the gastric antrum. An urgent esophagogastroduodenoscopy under general anesthesia was performed. The pin was securely grasped with rat-tooth forceps and extracted without incident. The patient's recovery was uneventful, and she was discharged on the first postoperative day. Conclusion: This case provides a high-fidelity validation of current international guidelines, demonstrating that a protocol-driven approach—encompassing rapid triage, definitive imaging, and urgent therapeutic endoscopy—is both safe and maximally effective for upper gastrointestinal sharp foreign bodies. The successful outcome underscores the critical importance of this management algorithm in preventing progression to life-threatening complications. This case-driven synthesis reinforces that adherence to a rigorous, evidence-based protocol is the most effective strategy to navigate this pointed clinical challenge and consistently achieve optimal patient outcomes.
The Pointed Challenge: Endoscopic Management of an Ingested Sharp Foreign Body and a Synthesis of Modern Techniques Sindhu Nugroho Mukti; Sigit Adi Prasetyo; Bernardus Parish Budiono
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 12 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i12.1465

Abstract

Background: The ingestion of sharp-pointed foreign bodies constitutes a high-acuity medical emergency, distinguished from other ingested objects by its significant potential for severe complications, including visceral perforation and hemorrhage. While flexible endoscopy has emerged as the cornerstone of management, its successful application hinges on a systematic, protocol-driven approach. This manuscript presents a case of an ingested straight pin and uses it as the framework for a critical synthesis of modern diagnostic and therapeutic strategies. Case presentation: A 40-year-old female presented to the emergency department, hemodynamically stable and completely asymptomatic, two hours after accidentally swallowing a straight pin. A benign abdominal examination belied the potential danger. Plain radiography confirmed a single, sharp metallic object in the gastric antrum. An urgent esophagogastroduodenoscopy under general anesthesia was performed. The pin was securely grasped with rat-tooth forceps and extracted without incident. The patient's recovery was uneventful, and she was discharged on the first postoperative day. Conclusion: This case provides a high-fidelity validation of current international guidelines, demonstrating that a protocol-driven approach—encompassing rapid triage, definitive imaging, and urgent therapeutic endoscopy—is both safe and maximally effective for upper gastrointestinal sharp foreign bodies. The successful outcome underscores the critical importance of this management algorithm in preventing progression to life-threatening complications. This case-driven synthesis reinforces that adherence to a rigorous, evidence-based protocol is the most effective strategy to navigate this pointed clinical challenge and consistently achieve optimal patient outcomes.
Co-Authors Bernardus Parish Budiono Rozy, Abdul Mughni Sagap, Ismail Bin Shobirin, Muhammad Ali Sigit Adi Prasetyo Sigit Adi Prasetyo, Sigit Adi Yan Wisnu Prajoko