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Nurhidayah Sarifuddin
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Agriculture, Biological Sciences & Forestry Dentistry Education Health Professions Medicine & Pharmacology Nursing Public Health Other

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Preparation and Characteristics of NLC Coenzym Q10 with A Combination of Hyaluronic Acid Nurhidayah Sarifuddin; Widji Soerarti; Noorma Rosita
Health Notions Vol 3, No 1 (2019): January
Publisher : Humanistic Network for Science and Technology (HNST)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (234.118 KB) | DOI: 10.33846/hn.v3i1.250

Abstract

Coenzyme Q10, often also known as ubiquinone, coenzyme Q10 or Q10, is soluble in lipids and is naturally present in plants, animals and in mitochondria. Coenzyme Q10 functions as an antioxidant that can protect the body from damage caused by free radicals. Hyaluronic acid is known as a hydrophilic polymer derived from polysaccharides which has the ability to increase percutaneous penetration by changing the composition of tightly arranged stratum corneum cells to increase the permeability of the skin. Nanostructured Lipid Carrier is a modification of the SLN system, consisting of a mixture of solid and liquid lipids (oil), stabilized by aqueous surfactant solution, is one method to increase drug penetration through the stratum corneum because it has several advantages. The purpose of this study was to see the effect of adding hyaluronic acid to the characteristics of the Nanostructure Lipid Carrier (NLC) as anti aging. Examination of characteristics including organoletis, pH, particle size and polidispersity index was carried out. The results of organoleptic NLC coenzym Q10-HA examination obtained dark orange color, liquid consistency, lipid efficacy odor and soft texture. The pH measurement results of the preparation ranged from 5.05-5.23. The results of the particle size examination ranged from 267-128 nm and the particle size distribution ranged between 0.308-0.200 Keywords: Coenzym Q10, Hyaluronic acid , NLC
FORMULASI DAN UJI AKTIVITAS ANTIBAKTERI MOUTHWASH EKSTRAK DAUN BELUNTAS (Pluchea Indica Less) TERHADAP STREPTOCOCCUS MUTANS nurhidayah sarifuddin
Biolearning Journal Vol 9 No 1 (2022): Biolearning Journal (Februari 2022)
Publisher : Universitas Pendidikan Muhammadiyah Sorong

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (287.639 KB) | DOI: 10.36232/jurnalbiolearning.v9i1.2267

Abstract

Daun beluntas (Pluchea indica L.) dengan kandungan kimia flavonoid, fenol dan tannin yang memiliki potensi sebagai antibakteri. Penelitian ini bertujuan untuk membuat formula obat kumur ekstrak daun beluntas serta melakukan uji stabilitas formula obat kumur, uji hedonik dan uji aktivitas antibakteri terhadap Streptococcus mutans. Formula obat kumur dibuat dengan variasi konsentrasi ekstrak daun beluntas 3, 5 dan 7%. Stabilitas sediaan obat kumur diuji dengan metode penyimpanan cycling test meliputi organoleptis, pH dan viskositas. Selain itu dilakukan uji hedonik terhadap kejernihan, warna, kekentalan dan aroma obat kumur. Hasil uji stabilitas menunjukkan bahwa formula obat kumur stabil secara fisik ditinjau dari pengamatan organoleptis, namun tidak stabil ditinjau dari parameter pH dan viskositas karena mengalami perbedaan sebelum dan setelah cycling test. Uji aktivitas antibakteri menunjukkan bahwa formula obat kumur memiliki aktivitas antibakteri dengan diameter zona hambat terbesar 8 mm pada konsentrasi 5%.
Co-Authors Noorma Rosita Widji Soerarti