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All Journal Indonesian Journal of Cancer Chemoprevention
M.Y. Yasmin Anum
Departement of Biochemistry, Faculty of Medicine, University Kebangsaan Malaysia
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology

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Chemopreventive Efficacy of Ginger Extract (Zingiber officinale) Harliansyah Harliansyah; W.N. Wan Zurinah; M.Y. Yasmin Anum; M. Noor Azian
Indonesian Journal of Cancer Chemoprevention Vol 1, No 2 (2010)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev1iss2pp118-123

Abstract

The liver cells were cultured in the presence of ginger extract at various concentrations (0-1 mg /ml) for 24 h and the cells viability and proliferation rate were evaluated by MTS and BrdU assays, while apoptosis was evaluated by colorimetric determination of caspase 8 and 3 activities. Ginger extract exhibited a dose dependent inhibition of viability and proliferation of WRL-68, HLE and HepG2 cells with IC50 of 569.69 ± 7.99 µg/ml, 389.71 ± 26.56 µg/ml and 358.71 ± 17.12 µg/ml respectively. Ginger extract induced apoptosis through activation of caspase-8 and 3 in a dose dependent pattern for all cells at concentration ranging from 0-500 mg/ml.  We found that antiproliferative effect of ginger extract could be associated with induction of apoptosis as shown by increased activities of caspase 8 and 3.The results from this study suggest that ginger extract has chemopreventive properties against hepatoma cells HepG2 and HLE by inhibiting cellular proliferation and inducing apoptosis.Keywords : antiproliferation, apoptosis, caspases, Zingiber officinale
Co-Authors Harliansyah Harliansyah M. Noor Azian W.N. Wan Zurinah