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All Journal Journal of Biomedicine and Translational Research Indonesian Journal of Obstetrics & Gynecology Science
Rabiah Adawiyah
Diponegoro University
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health

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Randomized Controlled Trial of Tranexamic Acid’s Effect on Bleeding Length: A Study on DMPA Users with Abnormal Uterine Bleeding Who Receive Low-Dose Oral Contraceptive Pill Rabiah Adawiyah; Inu Mulyantoro; Julian Dewantiningrum; Noor Pramono
Journal of Biomedicine and Translational Research Vol 6, No 1 (2020): April 2020
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jbtr.v6i1.4450

Abstract

ABSTRACTBackground: Contraceptive injection is the most common contraception used in Indonesia. Among the contraceptive injections, depomedroxy progesterone acetate (DMPA) is the most effective method with pregnancy rate of 0,3 pregnancy in 100 women annually. Abnormal uterine bleeding (AUB) is a common side effect occurred in DMPA users which leads to the discontinuation of contraception.Objective: To explore the effect of tranexamic acid on bleeding length for DMPA users with AUB who receive low dose Oral Contraceptive Pills (OCP).Methods: We performed double blind randomized control trial between  two groups to investigate the effect of tranexamic in managing AUB in DMPA users who receive low dose OCP. This study was performed in Dr. Kariadi Hospital Semarang, Indonesia. Forty-four subjects were divided into two groups, equally. Group 1 received 250 mg tranexamic acid four times a day for 5 days and OCP once a day for 28 days, while Group 2 received placebo four times a day for 5 days and OCP once a day for 28 days. Both groups were evaluated for bleeding length during treatment and were analyzed using Mann Whitney for post treatment with tranexamic acid.Results: The mean bleeding length was 5.2±3.62 days and 9.2±6.16 days in group 1 and 2 respectively. These bleeding lengths were significantly different between both groups (p=0.018). The precentage of subjects in whom bleeding was stopped during the first week after initial treatment was significantly higher in  group  1 than group 2 (77,3 % vs 45,5 %, p<0,030).Conclusion: Tranexamic acid significantly reduced the bleeding length in DMPA users who use OCP.
Efektivitas Pil Oral Kombinasi Dosis Rendah dalam Pengelolaan Perdarahan Uterus Abnormal pada akseptor DMPA Rabiah Adawiyah; Inu Mulyantoro
Indonesian Journal of Obstetrics & Gynecology Science Volume 2 Nomor 2 September 2019
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1361.126 KB) | DOI: 10.24198/obgynia.v2n2.161

Abstract

Tujuan: Untuk mengeksplorasi Efektivitas Pil Oral Kombinasi (POK) dalam Pengobatan Perdarahan Uterus Abnormal pada akseptor DMPA.Metode: Kami melakukan percobaan untuk menyelidiki efek pil oral kombinasi dosis rendah dalam pengelolaan PUA pada akseptor DMPA. Penelitian ini dilakukan di Rumah Sakit Dr. Kariadi Semarang, Indonesia. Desain penelitian yang digunakan adalah pra eksperimental. Dua puluh dua  akseptor DMPA diberikan terapi POK dosis rendah sekali sehari selama 28 hari (satu siklus), kemudian subjek dievaluasi untuk durasi perdarahan selama perawatan. Variabel bebas dalam penelitian ini adalah pemberian POK dosis rendah dan variabel dependen adalah jumlah hari perdarahan.Hasil: Terdapat penurunan bermakna rata-rata hari perdarahan  pada akseptor DMPA dengan PUA antara sebelum dan sesudah terapi POK dosis rendah dari 22,2(4,48) menjadi  9,2 (6,16) hari  (p=0,0001). Persentase dari subjek penelitian yang pendarahannya berhenti dalam minggu pertama setelah pengobatan adalah sebesar 45,5 %. Hanya terdapat satu orang yang mengeluhkan efek samping berupa pusing dan mual selama pengobatanKesimpulan: Pil Oral Kombinasi Dosis rendah  dapat mengurangi hari perdarahan pada akseptor DMPA Low Dose Oral Contraceptive Pills Efficacy in the Treatment of Abnormal Uterine Bleeding Secondary to DMPAAbstractObjective: To explore the effectivity of  Low Dose Oral Contraceptive Pills (LDOCP) in managing AUB in DMPA users. Method: We performed the study to investigate the effect of LDOCP in managing AUB in DMPA users. This study was performed in Dr. Kariadi Hospital Semarang, Indonesia. The study design is pre experimental. Twenty two subjects received LDOCP once a day for 28 day (one menstrual cycle). Subjects then evaluated for bleeding length during treatment. Independent variable in this study is LDOCP treatment and the dependent variable is the bleeding days.Result: The mean bleeding days in DMPA users with AUB were significantly reduced after LDOCP therapy from 22,2(4,48) days to  9,2 (6,16) days (p=0,0001). The precentage of subjects in whom bleeding was stopped during the first week initial treatment was 45,5 %. The mild side effects, such as dizziness and nausea, were experienced by only one subject.Conclusion : LDOCP significantly reduced  bleeding days in DMPA users with AUBKey words: OCP, PUA, DMPA, bleeding days
Co-Authors Inu Mulyantoro Julian Dewantiningrum Noor Pramono