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All Journal Journal of Biomedicine and Translational Research Livestock and Animal Research
Noor Pramono
Diponegoro University
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology Veterinary

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Randomized Controlled Trial of Tranexamic Acid’s Effect on Bleeding Length: A Study on DMPA Users with Abnormal Uterine Bleeding Who Receive Low-Dose Oral Contraceptive Pill Rabiah Adawiyah; Inu Mulyantoro; Julian Dewantiningrum; Noor Pramono
Journal of Biomedicine and Translational Research Vol 6, No 1 (2020): April 2020
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jbtr.v6i1.4450

Abstract

ABSTRACTBackground: Contraceptive injection is the most common contraception used in Indonesia. Among the contraceptive injections, depomedroxy progesterone acetate (DMPA) is the most effective method with pregnancy rate of 0,3 pregnancy in 100 women annually. Abnormal uterine bleeding (AUB) is a common side effect occurred in DMPA users which leads to the discontinuation of contraception.Objective: To explore the effect of tranexamic acid on bleeding length for DMPA users with AUB who receive low dose Oral Contraceptive Pills (OCP).Methods: We performed double blind randomized control trial between  two groups to investigate the effect of tranexamic in managing AUB in DMPA users who receive low dose OCP. This study was performed in Dr. Kariadi Hospital Semarang, Indonesia. Forty-four subjects were divided into two groups, equally. Group 1 received 250 mg tranexamic acid four times a day for 5 days and OCP once a day for 28 days, while Group 2 received placebo four times a day for 5 days and OCP once a day for 28 days. Both groups were evaluated for bleeding length during treatment and were analyzed using Mann Whitney for post treatment with tranexamic acid.Results: The mean bleeding length was 5.2±3.62 days and 9.2±6.16 days in group 1 and 2 respectively. These bleeding lengths were significantly different between both groups (p=0.018). The precentage of subjects in whom bleeding was stopped during the first week after initial treatment was significantly higher in  group  1 than group 2 (77,3 % vs 45,5 %, p<0,030).Conclusion: Tranexamic acid significantly reduced the bleeding length in DMPA users who use OCP.
Experimental animal models for polycystic ovarian syndrome (methods, effects, and implications) Erna Yovi Kurniawati; Noor Pramono; Syarief Thaufik Hidayat; Endang Mahati
Livestock and Animal Research Vol 22, No 1 (2024): Livestock and Animal Research
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/lar.v22i1.79197

Abstract

Many studies have replicated the clinical and genetic features of polycystic ovarian syndrome (PCOS) using a range of experimental animal models to improve treatment outcomes. This article aims to present an overview of the various experimental animal models that have been used in PCOS research. In this study, we conducted a systematic review of relevant research articles on the induced animal model PCOS. We searched research articles in Indonesian and English published over the last five years through three databases: PubMed, ScienceDirect, Google Scholar. We use established inclusion and exclusion criteria to select suitable articles. Out of 19 research articles included in our systematic review, we found the animal model PCOS based Rotterdam criteria, PCOS-IR model, PCOS-Inflammation model, PCOS-Gut microbiota model and PCOS-syndrome metabolic model. Androgen agents such as testosterone propionate, free testosterone, DHEA, and letrozole, as well as sodium valproate, are effective in the induction of PCOS phenotypes based on the Rotterdam criteria (oligo/amenorrhea, hyperandrogenic, and polycystic ovaries).
Co-Authors Endang Mahati Inu Mulyantoro Julian Dewantiningrum Kurniawati, Erna Yovi Rabiah Adawiyah Syarief Thaufik Hidayat