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All Journal Research Journal of Life Science PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Adeltrudis Adelsa Danimayostu
Universitas Brawijaya
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health Social Sciences

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The Effect of Niosomal System (Span 60-Cholesterol) on Diclofenac Sodium Preparation Characteristics and Diclofenac Sodium Preparation of Hydroxypropyl Cellulose Gel Base (HPC) Adeltrudis Adelsa Danimayostu; Esti Hendradi; Tutiek Purwanti
Research Journal of Life Science Vol 4, No 1 (2017)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat, Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (560.031 KB) | DOI: 10.21776/ub.rjls.2017.004.01.2

Abstract

Diclofenac sodium is a lipophilic drug. That characteristic makes it difficult to disperse well in hydrophilic gel base. The niosome with its vesicle system could overcome that low dispersibility. It affects penetration by reducing water loss in trans-epidermal layer and change lipid bilayer conformation. The present study was designed to investigate the effect of niosomal system (Span 60–Cholesterol) on preparation characteristics and diclofenac sodium penetration of hydroxypropyl cellulose (HPC) gel base. We examined three different formulas in HPC gel base. Formula III was made in niosomal system.  Preparation  characteristics were  evaluated with organoleptic and acidity tests. Drug penetration was checked using apparatus 5-paddle over disk and 0.45 μm Milipore membrane impregnated with isopropyl myristate. The solution is phosphate buffer saline pH 7.4±0.05 in temperature 37±0.5°C. All of the data were evaluated based on one way ANOVA and continued with HSD test. It was concluded that niosomal system (span 60-cholesterol) has an influence in increasing pH value and penetration (based on flux value and permeability) of diclofenac sodium in HPC gel base.
Pemanfaatan Limbah Cangkang Kerang sebagai Strategi Pemberdayaan UMKM: Utilization of Shellfish Shell Waste as a Strategy for MSME Empowerment Anisyah Achmad; Adeltrudis Adelsa Danimayostu; Rahmi Nurdiana; Kanthi Permaningtyas Tritisari; Martina Dini Dwi Rahmawati; Intaha Irsani; Melfin Fakhrul Asyiqin; Yunita Mudmaynah; Vebbina Ginting; Hanafi Saiful Anwar
PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol. 11 No. 6 (2026): PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/pengabdianmu.v11i6.12203

Abstract

Training on the utilization of shellfish shell waste is one strategy to support environmental management while increasing the economic value of micro, small, and medium enterprises (MSMEs). This study aimed to evaluate the development of participants’ knowledge and perceptions through a pre-test and post-test approach conducted in two stages of training. A descriptive quantitative method was employed, with 58 participants in the first training session and 38 in the second. The pre-test administered during the first session measured participants’ general knowledge of shellfish shell waste utilization, while the post-test conducted during the second session assessed participants’ advanced understanding, particularly regarding food safety and SPP-IRT licensing. The results showed that participants had a relatively high level of initial knowledge and were able to follow the advanced technical material in the subsequent stage. In addition, participants’ perceptions of the training indicated very high levels of participation and expectations. These findings suggest that a staged training approach can enhance MSMEs’ readiness to implement the utilization of shellfish shell waste in a more practical and sustainable manner.
Co-Authors Anisyah Achmad Esti Hendradi Hanafi Saiful Anwar Intaha Irsani Kanthi Permaningtyas Tritisari Martina Dini Dwi Rahmawati Melfin Fakhrul Asyiqin Rahmi Nurdiana Tutiek Purwanti Vebbina Ginting Yunita Mudmaynah