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Novia Indriyani Adisty
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Immunology & microbiology Public Health

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Salivary Cortisol Levels Representing Serum Cortisol Levels in Atopic Dermatitis Patients Novia Indriyani Adisty; Marsudi Hutomo; Diah Mira Indramaya
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 27 No. 3 (2015): BIKKK DESEMBER 2015
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (132.193 KB) | DOI: 10.20473/bikk.V27.3.2015.170-175

Abstract

Background: Atopic dermatitis (AD) is a chronic inflammatory skin disorder, recurrent lesion with a distinctive and specific distribution of lesions according phases. Patients with allergic diseases have been known to have a variety of patterns of cortisol. Dysfunction of the hypothalamic-pituitary-adrenal (HPA) axis and the role of cortisol has been studied in patients with DA. Free cortisol adrenal cortex is considered biologically active, which passively diffuses into all body fluids including saliva. Another advantage is the saliva examination is non-invasive, stress free and easy to do anywhere. Purpose: To analyze the correlation between levels of serum cortisol and salivary cortisol in patients with AD. Methods: Analytical, observational, cross-sectional study of the 29 AD patients who underwent blood and saliva samples by the method of "passive drooling" conducted on the hour 8:00 to 9:00 to see the levels of serum cortisol and salivary cortisol. Results: Twenty-nine subjects revealed mean serum cortisol levels 6,703,82g/dL, mean salivary cortisol levels was 1,430,96g/dL. Equation of salivary cortisol = 0,471+0,142*serum cortisol 2 (R=28,5%). Conclusions: The increasing of serum cortisol level of AD patients will result in increased levels of cortisol in saliva. Saliva collection methods by “passive drooling” were able to describe the serum cortisol levels at 28,5%.Key words: atopic dermatitis, serum cortisol, salivary cortisol.
Kaposi’s Sarcoma-associated Herpesvirus Novia Indriyani Adisty; Sawitri Sawitri; Willy Sandhika
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 28 No. 1 (2016): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (284.742 KB) | DOI: 10.20473/bikk.V28.1.2016.59-64

Abstract

Background: Kaposi’s sarcoma (KS) revealed by Moritz Kaposi first time in 1872. In the early 1980, the prevalence of SK began to increase dramatically. A new finding leads to growth, isolation, and characterization of a novel human herpes virus, now known as Kaposi’s sarcoma-associated herpes virus (KSHV) or Human herpes virus type 8 (HHV-8) from SK lesions. Puspose: To determine the role of herpes viruses in the pathogenesis of KS. Review: KS is a cancer that develops from cells lining the lymph vessels or blood vessels. A number of KSHV encoded protein is known to have the ability to oncogenic transformation, included are latent and lytic proteins. Latent proteins tend to increase survival and proliferation of infected cells, whereas lytic viral proteins are believed to support the growth factors and angiogenic paracrine secretion useful for tumor growth and progression. Conclusion: HHV-8 is necessary, but not sufficient to cause the KS, and other factors such as immunosuppression also play a role.Key words: Kaposi’s sarcoma, herpes viruses.
Co-Authors Diah Mira Indramaya Marsudi Hutomo Sawitri Sawitri Willy Sandhika