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Kristina Sihaloho

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Author-ID : 3287352

Immunology & microbiology Public Health

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Retrospective Study: Atopic Dermatitis in Childhood Kristina Sihaloho; Diah Mira Indramaya
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 27 No. 3 (2015): BIKKK DESEMBER 2015
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Atopic dermatitis is a chronically and relapsing inflammatory skin disease affecting individuals with atopic history or their families. Atopic dermatitis affects all ageswith percentage 15-30% in children and 1-2% in adults. Chronic pruritus, skin infection, sleep disorder, and growth disorder are signs and symptomps commonly found in childhood atopic dermatitis. Evaluation of the profile and management of DA were needed to improve the management of atopic dermatitis. Purpose:To evaluate the profile of childhood atopic dermatitis. Methods: A retrospective study of all new cases of childhood atopic dermatitis who visited the Pediatric Division, Dermatology and Venereology Outpatient Clinic, Dr. Soetomo General Hospital, Surabaya from January 2007 to Desember 2011. Results: Numbers of chilhood atopic dermatitis increased from 2007 to 2011. Itchy was the main complaint of DA, but redness patches (32,3%) and xerosis cutis (9,1%) were also found. Atopic history in patients and or their families were found in 842 patients (74,3%). Treatment was antihistamin in 879 patients (77,5%). Conclusions: Chilhood atopic dermatitis are still increasing by years. Determining and avoiding trigger factors are education for DA's patients and their families in preventing it recurrency.Key words: atopic dermatitis, childhood, retrospective study.

Expression of Transforming Growth Factor–Beta (TGF-β) on Regulatory T (Treg) Cell from Skin Lesion of Leprosy’s Patient Kristina Sihaloho; Afif Nurul Hidayati; Indropo Agusni
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 28 No. 1 (2016): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Clinical manifestations of leprosy depends on host’s immunity. Regulatory T (Treg) cells are known as CD4+CD25+FOXP3+ have roles in immune respons to maintain homeostasis. Transforming growth factor (TGF)-β are one of cytokine that is secreted by Treg cells. Treg cells are thought as unresponsiveness T cells (anergy) to Mycobacterium leprae and caused disease’s progression to lepromatosa. Purpose: To evaluate expression of TGF-β on Treg cells from patient leprosy’s skin lession. Methods: Design of study was cross-sectional, descriptive observation involving 18 leprosy patients who visited the Leprosy Division, Dermatology and Venereology Outpatient Clinic, Dr. Soetomo General Hospital, Surabaya. Biopsy from skin lession were performed then continued with histopathological examination. The type of leprosy was determined by clinical and histopathological examinations. Expression of TGF-β on Treg cell were performed by double staining immunohistochemistry in Biomoleculer and Pathology and Anatomy Laboratory at Brawijaya University, Malang. Result: Numbers of mid-borderline type (BB) leprosy’s patients were 2 (11,1%), 9 (50%) patients with borderline lepromatosa (BL) type, and 7 (38,5%) patients with Lepromatosa (LL) type. Mean expression of TGF-β on Treg cells from skin lession’s leprosy on BB type was 12 ± 2,12 cells/field of view, on BL type was 16 ± 3,64 cells/fields of view and on LL type was 22± 3,69 cells/field of view. Conclusion: Expression of TGF-β on Treg cells are increasing on skin lession’s leprosy patients might as prognostic indicator of severity of leprosy (lepromatosa type). Key words: immunohistochemistry, leprosy, Morbus Hansen, regulatory T cell, TGF-β.

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Journal : Berkala Ilmu Kesehatan Kulit dan Kelamin