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Incidence And Characteristics Intradialytic Hypertension Among Chronic Hemodialysis Patients Caused By Chronic Kidney Failure At Rsmh Palembang Period November 2018 Ghina Kartika; Suprapti Suprapti; Irfannuddin Irfannuddin
Majalah Kedokteran Sriwijaya Vol 51, No 1 (2019): Majalah Kedokteran Sriwijaya
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36706/mks.v51i1.8556

Intradialytic hypertension have 5 – 15 % incidence among chronic hemodialysis patients caused by chronic kidney failure. But, mostly medical practician focused only at intradialytic hypotension than intradialytic hypotension as the most frequent cardiovascular complications. Intradialytic hypertension itself is one of the cause of mortility and morbidity hemodialytic patients, that’s why patients should be aware of intradialytic hypertension. This study aims to know the frequencies of patients with intradialytic hypertension at RSMH Palembang period November 2018, and the characteristics of the patients based on patients sosiodemography, etiology of their chronic kidney disease, their hemodialysis period, and their activity during hemodialysis.Method : This study is descriptive analysis with total sampling, with primary data from patients blood pressure measurement, and interview with patients in hemodialysis installation at RSMH Palembang. In this study,305 samples were found, with 198 patients fulfilled inclusion criteria. Result : The result of this study shows that from 198 subjects, there are 116 (58,6%) of them who suffer intradialytic hypertension. Intradialityc hypertension patients mostly in the group age 46 – 65 years old (51%), male patients (61.2%) are more likely develop intradialytic hypertension than female patients (38.8%), patients with high educational backgroud also more likely to develop this complications. Their chronic kidney diseases cause are mostly hypertension (67,2%), and the higher activities patients during hemodialysis also more likely to develop intradialytic hypertension.Conclusion : Patients in hemodialysis installation at RSMH Palembang with intradialytic hypertension are more than the patients without the intradialytic hypertension (normotension and intradialytic hypotension patients are included), patients in old age group, male patients, and the higher patients activities during hemodialysis process the more highly patients develop intradialytic hypertension as complication.

Efficacy of 20% urea cream on uremic pruritus with uremic xerosis in chronic renal failure patients undergoing hemodialysis Yulia Farida Yahya; Nina Roiana; Rosi Andarina; Suprapti Suprapti; Irsan Saleh
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 30 No. 1 (2018): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Uremic pruritus (UP) is the most common symptoms in patients with chronic renal failure (CRF) undergoing hemodialysis (HD). It is a chronic itch sensation of the skin, with the most frequent clinical manifestation being xerosis, which is difficult to treat. There is a significant relationship between UP and moderate to severe uremic xerosis (UX) in CRF patients undergoing HD. This condition could affect the quality of life and increase the risk of morbidity and mortality. The causes of UP with xerosis are still unclear, however it is evident that there is a disruption of skin barrier function. A 20% urea with the base materials cream consisting sodium pidolat sodium lactate (NaPCA) and vegetable oils that act as a natural moisturizing factor (NMF) can improve the skin barrier function by increasing skin hydration, reducing transepidermal water loss (TEWL) will result in the improvement of UP with UX.

The Association between Urinary Tissue Inhibitor Metalloproteinase 2 (TIMP-2) and Insulin-like Growth Factor Binding Protein 7 (IGFBP-7) and Renal Recovery in Acute Kidney Injury Emilia; Zulkhair Ali; Ian Effendi; Novadian; Suprapti; Mediarty; Taufik Indrajaya; Mgs. Irsan Saleh
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 4 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i4.386

Background. Acute kidney injury (AKI) is a common and serious medical condition associated with significant increases in morbidity, mortality, cost of care and non recovery of kidney function that leads to progression to chronic kidney disease. Cell cycle arrest is implicated in the pathogenesis and repair process following AKI. The urinary cell-cycle arrest markers tissue inhibitor of metalloproteinase-2 (TIMP-2) and insulin-like growth factor binding protein 7 (IGFBP-7) have been utilized to predict the risk of AKI in many studies from specific population with good performance. However, their use in predicting recovery is still lacking. The aim of this study was to determine the association between two novel AKI biomarkers, urinary TIMP2 and IGFBP7 and renal recovery after 7 days of treatment in AKI patients at Dr. Mohammad Hoesin Hospital Palembang. Method. This was a prospective cohort study conducted in dr. Mohammad Hoesin Hospital Palembang from January 2021 until March 2021. Subjects enrolled in this study were patients whom diagnosed AKI based on KDIGO 2012 criteria. Urine samples were collected upon patients’ enrollment within 24 hours of AKI diagnosis. We utilized Sandwich Enzyme Linked Immunosorbant Assay (ELISA) method to detect urinary TIMP-2 and IGFBP-7 levels. The primary outcome is recovery from AKI after 7 days of treatment. Chi square test is used to analyze the association between urinary TIMP-2 and IGFBP-7 levels and renal recovery. Results. There were 70 subjects, only 22 of them were recovered after 7 days (31%). Median of urinary TIMP-2 and IGFBP-7 was 0,0047(0,0001-0,1439) [(ng/ml)2/1000]. There was significant association between urinary TIMP2 and IGFBP7 and renal recovery (p=0,027; OR 3,19; 95% CI 1,116-9,128). Conclusion. There was significant association between urinary TIMP2 and IGFBP7 and renal recovery in AKI patients.

The Association between Urinary Tissue Inhibitor Metalloproteinase 2 (TIMP-2) and Insulin-like Growth Factor Binding Protein 7 (IGFBP-7) and Renal Recovery in Acute Kidney Injury Emilia; Zulkhair Ali; Ian Effendi; Novadian; Suprapti; Mediarty; Taufik Indrajaya; Mgs. Irsan Saleh
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 4 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i4.386

Background. Acute kidney injury (AKI) is a common and serious medical condition associated with significant increases in morbidity, mortality, cost of care and non recovery of kidney function that leads to progression to chronic kidney disease. Cell cycle arrest is implicated in the pathogenesis and repair process following AKI. The urinary cell-cycle arrest markers tissue inhibitor of metalloproteinase-2 (TIMP-2) and insulin-like growth factor binding protein 7 (IGFBP-7) have been utilized to predict the risk of AKI in many studies from specific population with good performance. However, their use in predicting recovery is still lacking. The aim of this study was to determine the association between two novel AKI biomarkers, urinary TIMP2 and IGFBP7 and renal recovery after 7 days of treatment in AKI patients at Dr. Mohammad Hoesin Hospital Palembang. Method. This was a prospective cohort study conducted in dr. Mohammad Hoesin Hospital Palembang from January 2021 until March 2021. Subjects enrolled in this study were patients whom diagnosed AKI based on KDIGO 2012 criteria. Urine samples were collected upon patients’ enrollment within 24 hours of AKI diagnosis. We utilized Sandwich Enzyme Linked Immunosorbant Assay (ELISA) method to detect urinary TIMP-2 and IGFBP-7 levels. The primary outcome is recovery from AKI after 7 days of treatment. Chi square test is used to analyze the association between urinary TIMP-2 and IGFBP-7 levels and renal recovery. Results. There were 70 subjects, only 22 of them were recovered after 7 days (31%). Median of urinary TIMP-2 and IGFBP-7 was 0,0047(0,0001-0,1439) [(ng/ml)2/1000]. There was significant association between urinary TIMP2 and IGFBP7 and renal recovery (p=0,027; OR 3,19; 95% CI 1,116-9,128). Conclusion. There was significant association between urinary TIMP2 and IGFBP7 and renal recovery in AKI patients.

PUBLIC SEMINAR ON COVID-19 PREVENTION AMONG FAMILY CAREGIVERS OF HEMODIALYSIS PATIENTS Zulkhair Ali; Novadian Novadian; Suprapti Suprapti; Herleni Kartika; Eddy Yuristo
Conferences of Medical Sciences Dies Natalis Vol. 3 No. 1 (2021): Conference of Medical Sciences Dies Natalis Faculty of Medicine Universitas Sri
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (264.892 KB)

Covid-19 is usually severe and represents a poor outcome, particularly in patients who have underlying co-morbidities. Among end-stage renal disease patients dependent on dialysis, covid-19 was related to increased morbidity and mortality. There is no causative therapy currently for covid-19. Thus prevention is mainly the best attempt to limit the burden of the disease. The preventive measure may depend on vaccination and public behavior in controlling the spread of the SARS-CoV-2. In the setting of the dialysis center, the patients' and caregivers' compliance with preventive measures is critical in preventing the spreading of Covid-19. The individual's knowledge and attitudes of COVID-19 are likely to influence individual adherence. Evidence suggests that an individual’s knowledge is critical in combating pandemics. Current community service was aimed to increase family caregivers of dialysis patients’ knowledge on covid-19 prevention.

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