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All Journal Berkala Ilmu Kesehatan Kulit dan Kelamin
Marsoedi Hoetomo
Departemen/Staf Medik Fungsional Ilmu Kesehatan Kulit Dan Kelamin Fakultas Kedokteran Universitas Airlangga/Rumah Sakit Umum Daerah Dr. Soetomo Surabaya
Immunology & microbiology Public Health

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Eosinophil and Eosinophil Cationic Protein Level Raising in Dermatitis Due to Food Patients Umborowati, Menul Ayu; Sawitri, Sawitri; Hoetomo, Marsoedi
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol 27, No 2 (2015): BIKKK AGUSTUS 2015
Publisher : Faculty Of Medicine Airlangga University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (115.225 KB) | DOI: 10.20473/bikkk.V27.2.2015.90-96

Abstract

Background: Food allergy prevalence worldwide has been increase. Skin is secondary most often target organ in food allergy reaction. Food allergy affects 35% atopic dermatitis (AD) patients. Diagnosis of food allergy  is still challenge because signs are not specific. Previous researches showed eosinophil and eosinophil cationic protein (ECP) role in food allergy reaction on gastrointestinal tract, but none on dermatitis due to food. Purpose: To evaluate eosinophil and serum ECP in dermatitis due to food. Method: This is a descriptive observational cross sectional study, with dermatitis due to food patients in Dermatovenereology Outpatient Clinic Dr. Soetomo General Hospital Surabaya as subjects. Subjects has been collected trough consecutive sampling during 3 months, then data were analysized descriptively Results: Serum ECP level of dermatitis due to food patients were above normal range in all subjects, with mean level 108.5 µg/L, lowest level 33.011 µg/L and higher level 284.849 µg/L. Mean eosinophil of dermatitis due to food patients just arise above normal limit (0.413µg/L). AD patients were 48.4% among all subjects. Mean serum ECP level of AD patients was higher (121.703 µg/L) than non-AD (96.123 µg/L). Conclusions: Eosinophil and ECP seems have role in dermatitis due to food pathogenesis. Serum ECP examination can be benefits to monitor dermatitis due to food severity.Key words: dermatitis due to food, eosinophil, serum eosinophil cationic protein.
Eosinophil and Eosinophil Cationic Protein Level Raising in Dermatitis Due to Food Patients Menul Ayu Umborowati; Sawitri Sawitri; Marsoedi Hoetomo
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 27 No. 2 (2015): BIKKK AGUSTUS 2015
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (115.225 KB) | DOI: 10.20473/bikk.V27.2.2015.90-96

Abstract

Background: Food allergy prevalence worldwide has been increase. Skin is secondary most often target organ in food allergy reaction. Food allergy affects 35% atopic dermatitis (AD) patients. Diagnosis of food allergy  is still challenge because signs are not specific. Previous researches showed eosinophil and eosinophil cationic protein (ECP) role in food allergy reaction on gastrointestinal tract, but none on dermatitis due to food. Purpose: To evaluate eosinophil and serum ECP in dermatitis due to food. Method: This is a descriptive observational cross sectional study, with dermatitis due to food patients in Dermatovenereology Outpatient Clinic Dr. Soetomo General Hospital Surabaya as subjects. Subjects has been collected trough consecutive sampling during 3 months, then data were analysized descriptively Results: Serum ECP level of dermatitis due to food patients were above normal range in all subjects, with mean level 108.5 µg/L, lowest level 33.011 µg/L and higher level 284.849 µg/L. Mean eosinophil of dermatitis due to food patients just arise above normal limit (0.413µg/L). AD patients were 48.4% among all subjects. Mean serum ECP level of AD patients was higher (121.703 µg/L) than non-AD (96.123 µg/L). Conclusions: Eosinophil and ECP seems have role in dermatitis due to food pathogenesis. Serum ECP examination can be benefits to monitor dermatitis due to food severity.Key words: dermatitis due to food, eosinophil, serum eosinophil cationic protein.
Perbedaan Kadar Malondialdehid (MDA) pada Pasien Dermatitis Atopik dan Non Dermatitis Atopik Lia Kinasih Ayuningati; Dwi Murtiastutik; Marsoedi Hoetomo
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 30 No. 1 (2018): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (578.411 KB) | DOI: 10.20473/bikk.V30.1.2018.58-65

Abstract

Latar Belakang : Malondialdehid (MDA) adalah senyawa dialdehida yang merupakan produk akhir peroksidasi lipid dalam tubuh, konsentrasi MDA yang tinggi menunjukkan adanya proses oksidasi dalam membran sel. Dermatitis Atopik (DA) adalah penyakit radang kulit yang bersifat kronis dan residif, dengan gejala gatal dapat terjadi pada bayi, anak, dewasa dan biasanya terdapat riwayat asma maupun rhinitis alergi pada diri sendiri atau pada anggota keluarga. Sejumlah penelitian terdahulu menunjukkan MDA telah membantu menjelaskan peranan stres oksidatif pada sejumlah penyakit termasuk pada DA yang berperan dalam proses terjadinya inflamasi. Tujuan:  Mengevaluasi status stres oksidatif pada pasien DA di Unit Rawat Jalan (URJ) Kesehatan Kulit dan Kelamin RSUD Dr. Soetomo Surabaya. Metode: Penelitian analitik observasional dengan 50 sampel yang terbagi menjadi dua kelompok dengan jumlah 25 untuk pasien DA dan 25 non DA yang memenuhi kriteria penerimaan dan penolakan. Hasil: Rerata kadar MDA kelompok DA diperoleh nilai 129,14 + 57,31 ng/mL sedangkan pada kelompok non DA diperoleh nilai MDA 73,91 + 32,89 ng/mL. Dari hasil yang ada diketahui bahwa kadar MDA plasma pada pasien DA lebih tinggi bila dibandingkan dengan non DA dan perbedaan ini bermakna signifikan. Simpulan: Kadar MDA pada pasien DA lebih tinggi dibanding non DA. Diperlukan penelitian lebih lanjut menggunakan desain time series untuk mengetahui lebih jauh peran MDA dalam patogenesis DA dan perlu dilakukan penelitian lanjutan yang menunjukkan korelasi peningkatan kadar MDA degan derajat keparahan DA.
Co-Authors Dwi Murtiastutik Lia Kinasih Ayuningati Menul Ayu Umborowati Menul Ayu Umborowati, Menul Ayu Sawitri Sawitri Sawitri Sawitri