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All Journal Berkala Ilmu Kesehatan Kulit dan Kelamin Archives of The Medicine and Case Reports
Densy Violina Harnanti
Departemen/Staf Medik Fungsional Kesehatan Kulit Dan Kelamin Fakultas Kedokteran Universitas Airlangga/Rumah Sakit Umum Daerah Dr. Soetomo Surabaya
Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Evaluasi Penggunaan Terapi Topikal Tretinoin 0,1% pada Striae Albae Densy Violina Harnanti; M Yulianto Listiawan; Linda Astari; Willy Sandhika
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 31 No. 2 (2019): AGUSTUS
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (347.9 KB) | DOI: 10.20473/bikk.V31.2.2019.98-103

Abstract

Latar belakang: Striae distensae (SD) adalah jaringan parut linier pada epidermis dan dermis akibat peregangan kulit yang melebihi batas elastisitasnya. Striae albae (SA) ditandai dengan garis hipopigmentasi dan terjadinya atrofi pada epidermis dan dermis. Hal tersebut dapat mengganggu fungsi sawar kulit bahkan gangguan transepidermal water loss (TEWL). Tujuan: Mengevaluasi perubahan klinis dan luas kolagen pasien SA sebelum dan setelah  terapi  tunggal krim tretinoin 0,1% selama 3 bulan. Metode: Penelitian eksperimental analitik yang membandingkan perubahan klinis dan persentase luas kolagen pasien SA sebelum dan setelah  terapi  tunggal krim tretinoin 0,1% selama 3 bulan di Unit Rawat Jalan (URJ) Kesehatan Kulit dan Kelamin Divisi Kosmetik dan Tumor Bedah Kulit Rumah Sakit Umum Daerah (RSUD)  Dr. Soetomo Surabaya. Hasil: Panjang lesi SA sebelum dan setelah terapi krim tretinoin 0,1% tidak didapatkan perbedaan bermakna (p=0,341), begitu pula lebar lesi SA sebelum dan setelah terapi juga tidak didapatkan perbedaan yang bermakna (p=0,341). Persentase luas  kolagen sebelum dan setelah terapi krim tretinoin 0,1% didapatkan perbedaan yang bermakna (p=0,0001). Visual Analog Scale (VAS) Improvement grade dengan skala 2 didapatkan pada 10 (90,9%) sampel penelitian sedangkan skala 3 didapatkan pada 1 (9,1%) sampel penelitian. Hasil penilaian VAS patient satisfaction grade didapatkan 10 (90,9%) sampel penelitian memberikan skala 6 dan 1 (9,1%) memberikan skala 7. Simpulan: Penggunaan krim tretinoin 0,1% pada SA selama 3 bulan tidak menunjukkan perubahan klinis yang bermakna, tetapi dapat meningkatkan persentase luas kolagen secara bermakna. 
Basal Cell Carcinoma (BCC) with Risk Factors of Exposure to Burns: A Case Report Study Ningtyas, Indri Ari; Densy Violina H; Yohana Octavianda
Archives of The Medicine and Case Reports Vol. 5 No. 3 (2024): Archives of The Medicine and Case Reports
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/amcr.v5i3.567

Abstract

Basal cell carcinoma (BCC) is the most common skin cancer, with a higher incidence than all other malignancies combined. Although metastases are rare, patients with multiple or frequently recurrent BCC can suffer from major and difficult-to-manage comorbidities. The choice of therapy in cases of skin cancer must be adjusted based on the type of histological lesion, size, location and age of the patient. No single therapy is ideal for all lesions. We report a case of BCC in a woman in a limited health facility without a dermatologist venereology oncology specialist. A 41-year-old woman came with complaints of a lump on her right cheek that had been slowly enlarging for the last 4 years and a week ago complained of itching at the edge of the lump. Local examination revealed a skin-colored nodule with surrounding telangiectasis. Even though the lump previously did not show any symptoms, the patient wanted the lump removed. The doctor decided to perform excision surgery. Histopathology results showed nodular BCC and the tumor had grown to the edge of the tissue, therefore the doctor decided to refer to an oncologist for additional surgery or radiotherapy. In conclusion, multiple BCC in women in limited health facilities is a complex challenge. Collaboration between general practitioners, specialist doctors, and other stakeholders is needed to increase access to quality health services and improve treatment outcomes for patients with BCC in remote areas.
Co-Authors Linda Astari, Linda M. Yulianto Listiawan Ningtyas, Indri Ari Willy Sandhika Yohana Octavianda