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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Berkala Ilmu Kesehatan Kulit dan Kelamin Indonesian Journal of Tropical and Infectious Disease ISM (Intisari Sains Medis) : Jurnal Kedokteran JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Jurnal EduHealth Molucca Medica

Linda Astari, Linda

Departemen/Staf Medik Fungsional Ilmu Kesehatan Kulit Dan Kelamin Fakultas Kedokteran Universitas Airlangga/Rumah Sakit Umum Daerah Dr. Soetomo Surabaya

Author-ID : 3287335

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Earth & Planetary Sciences Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Susceptibility test of Griseofulvin, Ketoconazole, Itraconazole, and Terbinafine to Dermatophyte Species Using Microdilution Method Anggarini, Dyah Ratri; Sukanto, Hari; Astari, Linda; Endraswari, Pepy Dwi
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol 27, No 1 (2015): BIKKK APRIL 2015
Publisher : Faculty Of Medicine Airlangga University

Backgroud: Dermatophytosis is common disease in tropical countries such as Indonesia. The prevalence of dermatophytosis in general population also high (20%). The dermatophyte fungi are the etiologic agents that cause this disease, some of them had already reported to be resistant to some anti-fungi. Purpose: To determine dermatophyte species causing dermatophytosis and the resistancy of griseofulvin, ketoconazole, itraconazole, dan terbinafine to dermatophyte species. Methods: Isolates of dermatophyte from patient who met the inclusion criteria in outpatient clinic of dermato-venereology Dr. Soetomo Hospital Surabaya during October until December 2014 were analyzed with respect to their susceptibility to four anti-fungal agents (griseofulvin, ketoconazole, itraconazole, and terbinafine) using microdilution methode. Results: Thirthy patients were included in inclusion criteria, with T. mentagrophytes var. Interdigitale was the most common cause of dermatophytoses. According to MIC all 30 isolates were already resistant to all anti-fungal agent, except T. rubrum that still sensitive to ketoconazole and 80,Â itraconazole.Â Conclusion: According to MIC 16.7% isolates sensitive to griseofulvin, 23.3% to ketoconazole, 16.7% to 80 itraconazole and 20% to terbinafine.Key word: dermatophyte species, susceptibility test of anti-fungal, microdilution.

Susceptibility test of Griseofulvin, Ketoconazole, Itraconazole, and Terbinafine to Dermatophyte Species Using Microdilution Method Dyah Ratri Anggarini; Hari Sukanto; Linda Astari; Pepy Dwi Endraswari
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 27 No. 1 (2015): BIKKK APRIL 2015
Publisher : Faculty of Medicine, Universitas Airlangga

Backgroud: Dermatophytosis is common disease in tropical countries such as Indonesia. The prevalence of dermatophytosis in general population also high (20%). The dermatophyte fungi are the etiologic agents that cause this disease, some of them had already reported to be resistant to some anti-fungi. Purpose: To determine dermatophyte species causing dermatophytosis and the resistancy of griseofulvin, ketoconazole, itraconazole, dan terbinafine to dermatophyte species. Methods: Isolates of dermatophyte from patient who met the inclusion criteria in outpatient clinic of dermato-venereology Dr. Soetomo Hospital Surabaya during October until December 2014 were analyzed with respect to their susceptibility to four anti-fungal agents (griseofulvin, ketoconazole, itraconazole, and terbinafine) using microdilution methode. Results: Thirthy patients were included in inclusion criteria, with T. mentagrophytes var. Interdigitale was the most common cause of dermatophytoses. According to MIC all 30 isolates were already resistant to all anti-fungal agent, except T. rubrum that still sensitive to ketoconazole and 80, itraconazole. Conclusion: According to MIC 16.7% isolates sensitive to griseofulvin, 23.3% to ketoconazole, 16.7% to 80 itraconazole and 20% to terbinafine.Key word: dermatophyte species, susceptibility test of anti-fungal, microdilution.

Higher Level Zinc Serum in Multibacillary Leprosy With Erythema Nodosum Leprosum compared to Patients Without Reaction Kinanti Prabawaningrum; Linda Astari; Indropo Agusni
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 28 No. 1 (2016): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Leprosy is an infectious disease that causes a redistribution of nutrients in the body, including zinc, and low food intake of zinc causes decreased serum zinc levels. The number of bacteria M. leprae in multibacillary (MB) type leprosy and acute inflammatory process in Erythema Nodosum Leprosum (ENL) reaction affect the levels of zinc. Purpose: To analyze differences in the results of serum zinc levels in MB patients without reactions and ENL. Methods: Cross sectional study was conducted on forty-eight patients with a diagnosis of MB leprosy in Dermato and venereology Outpatient Clinic Dr. Soetomo General Hospital Surabaya. Patient's blood had been taken to examine serum zinc levels. Result: The mean serum zinc levels of MB patients without reaction 78.49 g/dL, while ENL 175.83 g/dL. Conclusion: The mean serum zinc levels of MB patients with ENL is higher than without reaction.Key words: MB leprosy, ENL, cross sectional, serum zinc.

Profile of New Patients with Candida Infection in Skin and Nail Shinta Dewi Rahmadhani Soetojo; Linda Astari
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 28 No. 1 (2016): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Candidiasis are different groups of infection which is caused by Candida albicans and other spesies in the genus Candida can invade hair, skin, nail, mucous membrane and systemic. Purpose: To evaluate profile, process of diagnosis, treatment and follow up of patient with candida infection on the skin and nails. Methods: This research was performed retrospectively to new patients with candida infection of skin and nails in period of 2011-2013. Result: There were 137 patients in period 2011-2013, which are 114 new patients with infection in skin and 23 patients with nails involvement. Most of them were women, respectively in 2011 (54.3%) 2012 (80%) and 2013 (56.6%). Most types of skin disorder is candida intertriginosa (62.2%) and candidiasis of skin and nails (91.3%). Conclusion: Overview of new cases of candida infections of skin and nails tend to decrease.Key words: Candidiasis spp, candida infection of skin and nails.

Parker ink-KOH stain, Chicago Sky Blue (CSB) stain, and Fungi Culture, for The Diagnosis of Superficial Dermatomycoses Sunarso Suyoso; Anggraeni Noviandini; Linda Astari
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 29 No. 1 (2017): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Superficial dermatomycoses are infections of skin, nails, and hair that can be divided into dermatophyte, pityriasis versicolor (PV), and candidiasis based on the causative pathogens. Rapid diagnosis is important to initiate the treatment earlier. To establish the diagnosis, direct microscopy using potassium hydroxide and culture examinations could be performed. Although the routine examination using Parker ink-KOH staining could be done in very short time, it was lacking of color contrast and requiring considerable skill interpretation. Various contrast dyes are available including a new contrast Chicago Sky Blue (CSB) staining. Purpose: To evaluate the result of Parker ink-KOH stain, CSB stain, and culture for the diagnosis of superficial dermatomycoses. Methods: The study was an observational descriptive research. Skin scrappings from patients with clinical diagnosis of superficial dematomycoses in Dermatology and Venereology Outpatient Clinic Dr. Soetomo General Hospital were examined using Parker ink-KOH stain, CSB stain, then interpreted by a researcher and analysts. The samples were also cultured. Results: A total of 45 samples, 71.1% revealed dermatophyte patients, 22.2% PV patients, and 6.7% candidiasis patients. The fungal filaments were detected in Parker ink-KOH stain by researcher 91.11% of the samples and by analysts 95.56%. CSB stain were detected 100% in all the samples by both observers. The culture was positive in 71.1% samples. Conclusion: CSB stain provides a good color contrast and shown a promising examination as it is rapid, simple, and easy to interpret for the diagnosis of superficial dermatomycoses, thus it is suitable to apply for inexperienced clinicians in dermtology clinical setting and laboratory.

Effect of Lactobacillus plantarum on Total Immunoglobulin E Serum and Scoring Atopic Dermatitis (SCORAD) Index in Children With Atopic Dermatitis Renata Prameswari; Linda Astari; Afif Nurul Hidayati; Cita Rosita Sigit Prakoeswa
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 29 No. 2 (2017): AGUSTUS
Publisher : Faculty of Medicine, Universitas Airlangga

Background: The prevalence of atopic dermatitis (AD) has been increased for several decades. T-helper cell (Th)1 and Th2 disregulation influence the level of immunoglobulin (Ig)E and interfere Scoring Atopic Dermatitis (SCORAD) index. Management approachment only relieved the symptoms, therapy with probiotic are potentially improve this disregulation. Lactobacillus plantarum (LP) has been fullfilled as probiotic criteria and it’s safely used in human. Methods: In a randomized, double-blind, placebo-controlled trial, twenty (22) patients were randomized to take LP or placebo for 12 weeks with 2 weeks wash-out period in Pediatric Division, Dermatology and Venereology Outpatient Clinic. Total IgE serum level and SCORING indeks were evaluted before and after intervention. Results: Twelve (12) patients in probiotic group and 10 patient in placebo group completed the study. Our findings revealed that there is no significant different in total IgE serum between LP (504.533 IU/ml ± 415.686 IU/ml) and placebo (909.580 ± 885.051 IU/ml) respectively (p=0.117). Mean decreased difference of SCORAD index in LP group (36.784 ± 8.705) significant greater than placebo (26.860 ± 5.021) respectively (p= 0.000). Conclusion: Total IgE serum in both group not significantly different. However, SCORAD indeks in LP group showed a significantly greater reduction. LP is beneficial in the treatment of children with AD.

Profile and Evaluation of Dermatophytosis Ardhiah Iswanda Putri; Linda Astari
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 29 No. 2 (2017): AGUSTUS
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Dermatophytosis is an infection of the tissues, for example, the stratum corneum of the epidermis, hair, and nails, which is caused by dermatophyte fungi group. This retrospective study has never been done before and the 2011-2013 election was conducted due to changes in the health insurance system at RSUD Dr. Soetomo. Purpose: To evaluated patient management of dermatophytosis in Mycology Division Outpatient Clinic Dr. Soetomo General Hospital 2011-2013. Methods: A descriptive retrospective study the aim to evaluated general description, epidemiology, clinical manifestation, establisment diagnosis, management and repeated control new patient dermatophytosis. Results: Percentage new case dermatophytes infection increased, but the number of visits to URJ for 3 years decreased. The most diagnosis is tinea corporis. Most cases come from Surabaya. The most patient complaints are itching. The most efflorescence is polycyclic. Griseofulvin is the most therapeutic choice given in the case of tinea corporis. Conclusions: In this study most cases of dermatophytosis is tinea korporis. The diagnosis approach of dermatophytosis diagnosis was obtained by anamnesis, physical examination, and additional examination. Most of dermatophytosis treated with antifungal griseofulvin.

Tinea Capitis Favus-Like Appearance: Problem of Diagnosis Dwi Ratna Adisty; Linda Astari
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 29 No. 3 (2017): DESEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Tinea capitis (TC) is an infection of scalp, hair follicles, and the surrounding skin, caused by dermatophyte fungi. Favus, a chronic inflammatory tinea capitis typically seen in Trichophyton schoenleinii infection. Favus is characterized by ‘scutula’. Favus may result in cicatricial alopecia. Purpose: To understand the clinical manifestation and management of tinea capitis. Case: A girl, 8 year-old, 18 kg, with thick crust located at the center of the head since 3 months, became spreading overtime. There were itchy sensation, no fever, no pain. There was history of an itchy red patch on her neck which diminished with topical antifungal. Dermatological examination revealed multiple thick brown-yellow crust sharply marginated, there were erosion and alopecia area beneath the crust. There were no sign of inflammation, no pustule, no enlargement of cervical and occipital lymphnodes on palpation. Discussion: Wood’s light examination showed no fluorescence and potassium hydroxide (KOH) showed no spores. Result of fungal culture was no colony growth. Patient was given griseofulvin 20 mg/kg body weight/day, wet dressing, and ketoconazole 2% shampoo twice weekly. Good clinical result shown after 10 weeks. Conclusion: Diagnosis of TC established based on history taking, clinical findings, Wood’s light examination, KOH preparation, fungal culture. A negative culture may arise because antifungal treatment had been used prior to collection of the specimen. Griseofulvin still became the drug of choice for tinea capitis even there are new generations of antifungal.

Peningkatan Jumlah Protein S100 pada Vitiligo setelah Terapi Narrowband-Ultraviolet B Putri Hendria Wardhani; M. Yulianto Listiawan; Linda Astari
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 30 No. 2 (2018): AGUSTUS
Publisher : Faculty of Medicine, Universitas Airlangga

Latar Belakang: Vitiligo adalah penyakit depigmentasi yang paling sering dijumpai dengan manifestasi klinis berupa makula berwarna putih susu berbatas tegas, dengan patogenesis kompleks yang belum dipahami dengan baik sehingga evolusi penyakit tidak dapat diprediksi dan hasil terapi seringkali tidak memuaskan. Sampai sekarang Narrowband-Ultraviolet B (NB-UVB) dianggap sebagai pengobatan vitiligo yang paling efektif dan aman. Evaluasi terapi dengan melihat jumlah melanosit melalui pemeriksaan imunohistokimia protein S100 akan menjadi lebih objektif dan akurat. Tujuan: Untuk membandingkan jumlah protein S100 pada pasien vitiligo sebelum dan setelah terapi NB-UVB. Metode: Penelitian ini merupakan penelitian eksperimen analitik komparatif dengan menggunakan metode pre-post test yang membandingkan protein S100 pada pasien vitiligo sebelum dan setelah mendapatkan terapi NB-UVB yang dilakukan di Unit Rawat Jalan, RSUD Dr. Soetomo Surabaya. Dua belas sampel kasus yang didiagnosis vitiligo diobati dengan terapi NB-UVB dua kali seminggu sampai 8 kali terapi. Dosis awal adalah 200 mJ dan secara bertahap meningkat 20% setiap terapi. Dilakukan biopsi sebelum dan setelah terapi dan kemudian protein S100 dibandingkan dengan menggunakan pewarnaan imunohistokimia. Hasil: Terdapat perbedaan yang bermakna antara jumlah protein S100 pada vitiligo sebelum dan setelah terapi NB-UVB dengan nilai p=0,002 (p=<0,05). Simpulan: Pemeriksaan imunohistokimia protein S100 berguna sebagai indikator keberhasilan terapi pada vitiligo.

Faktor Risiko Kandidiasis Vulvovaginalis (KVV) Dewi Puspitorini; Linda Astari; Yuri Widya; Sylvia Anggraeni; Evy Ervianti; Cita Rosita Sigit Prakoeswa; Sunarso Suyoso
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 30 No. 3 (2018): DESEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Latar Belakang: Kandidiasis vulvovaginalis (KVV) merupakan penyakit inflamasi vulva dan vagina yang disebabkan oleh spesies Candida. Penyakit ini menyerang hampir tiga per empat wanita usia subur. Terdapat berbagai faktor yang berpengaruh terhadap kejadian penyakit ini. Penanganan yang baik terhadap faktor-faktor tersebut diharapkan dapat menurunkan angka kejadian KVV. Tujuan: Mengevaluasi faktor-faktor yang memengaruhi KVV. Metode: Penelitian ini bersifat deskriptif cross-sectional untuk mengamati faktor-faktor predisposisi KVV pada 12 April 2017 hingga 11 Juli 2017 di Unit Rawat Jalan RSUD Dr Soetomo Surabaya. Hasil: Didapatkan 25 pasien KVV dengan distribusi usia terbanyak adalah usia 15-24 tahun, lama keluhan terbanyak adalah 1-9 bulan, riwayat predisposisinya antara lain diabetes melitus, kondisi penurunan sistem imun, dan yang terbanyak adalah pemakai douching vagina. Hasil pemeriksaan klinis didapatkan semua pasien dengan vulva dan vagina eritema dan edema. Hasil pemeriksaan sediaan basah didapatkan blastospora positif dengan pseudohifa negatif sebesar 20%, blastospora positif dengan pseudohifa positif sebesar 48%, blastospora negatif dengan pseudohifa negatif sebesar 32%, dan tidak didapatkan blastospora negatif dengan pseudohifa positif. Pemeriksaan mikroskopis pengecatan Gram didapatkan blastospora positif dengan pseudohifa negatif sebesar 16%, blastospora negatif dengan pseudohifa positif sebesar 4%, blastoposra positif dengan pseudohifa positif sebesar 52%, dan blastospora negatif dengan pseudohifa negatif sebesar 28%. Didapatkan 100% sampel tumbuh koloni pada media Saboroud Dextrose Agar (SDA). Simpulan: KVV disebabkan oleh spesies Candida, yang tumbuh 100% pada media SDA. Terdapat faktor-faktor predisposisi yang sangat berpengaruh terhadap kejadian KVV.

Co-Authors Afif Nurul Hidayati Afif Nurul Hidayati, Afif Nurul Alarik L., Albertus Alimsardjono, Lindawati Alpha Fardah Athiyyah Alya Nuha Andini Amanda Gracia Manuputty Anang Endaryanto Anggraeni Noviandini Anggraeni, Sylvia Ardhiah Iswanda Putri Arifa Mustika Astindari Astindari Astindari Astindari, Astindari Aulia, Syifa Auliya, Arsya Axelia, Presstisa Gifta Bagus Bagus Bagus Haryo Kusumaputra, Bagus Haryo Bramantono Bramantono, Bramantono Brigita Ika Rosdiana Budi Prasetyo Budi Utomo Budi Utomo Budiono Budiono Chesia Christiani Liuwan Christina Avanti Cita Rosita Sigit Prakoeswa Damayanti Damayanti Damayanti Damayanti Damayanti Damayanti Damayanti David Sontani Perdanakusuma Densy Violina Harnanti Desiana Widityaning Sari Dewi Puspitorini Dhyah Aksarani Handamari Diah Mira Indramaya DINAR ADRIATY Dwi Murtiastutik Dwi Ratna Adisty Dwiyanti Puspitasari, Dwiyanti Dyah Ratri Anggarini Dyah Ratri Anggarini, Dyah Ratri Endang Wahyu Fitriani Erwin Astha Triyono Esti Hendradi Eva Lydiawati Evy Ervianti Fadila, Arisia Farhat Surya Ningrat Hadiwidjaja, Farsha Naufal Hari Sukanto, Hari Harningtyas, Citra Dwi Hartanto, Felix I Gusti Ayu Agung Elis Indira I Gusti Nyoman Darmaputra Indah Purnamasari Indiastuti, Danti Nur INDROPO AGUSNI Ingrid Suryanti Suryono Irmadita Citrashanty Irmadita Citrashanty, Irmadita Iskandar Zulkarnain Iskandar Zulkarnain ISWAHYUDI ISWAHYUDI Kathrin Kezia Henry Kinanti Prabawaningrum Kurniati Kurniati M. Yulianto Listiawan ManikRetno Wahyunitisari Mappamasing, Hasnikmah Maylita Sari Maylita Sari, Maylita Medhi Denisa Medhi Denisa Alinda, Medhi Denisa Meita Ardini Pratamasari, Meita Ardini Merilyne Merilyne Musofa Rusli Ngesti Kumalasari, Diah Noviannisa, Farah Ayu Nyoman Suryawati Pepy D. Endraswari Pepy Dwi Endraswari, Pepy Dwi Prakoeswa, Cita Rosita Priangga Adi Wiratama Puspowati, Erindah Putri Hendria Wardhani Putri, Melati Adinda Rahmadewi Rahmadewi Rahmadewi Rahmatari, Bandaru RATNA WAHYUNI Regitta Indira Agusni Renata Prameswari Retha Retha Ridha Ramadina Widiatma Riyana Noor Oktaviyanti Sawitri Sawitri Sawitri Selvia Yuliani Dwi Ratih Sanggarwati Sepling Paling Sheilaadji, Maria Ulfa Shinta Dewi Rahmadhani Soetojo SHINZO IZUMI Siti Kurniawati Sulaksanaswastho Suyoso Sunarso Suyoso Sunarso Suyoso Sunarso Suyoso Sunarto, Olivia Awwalin Susanto, Ester Chateline Tjokorde Istri Nyndia Vaniari Trisniartami Setyaningrum Vidyani Adiningtyas Widyantari, Septiana Willy Sandhika Yuri Widia, Yuri Yuri Widya Zahruddin Ahmad

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