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All Journal Indonesian Journal of Chemistry Journal Of Carbazon
Rosnani Nasution
Department of Chemistry, Syiah Kuala University
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Materials Science & Nanotechnology

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In Silico Investigation of γ-Sitosterol Isolated from the Ethanol Extract of Artocarpus camansi Leaves as a Sunscreen Agent Nasution, Rosnani; Azura, Rafna; Bahi, Muhammad; Maulydia, Nur Balqis; Bastian, Reza Akbar; Hilda, Michelia Mutiara; Marianne, Marianne
Indonesian Journal of Chemistry Vol 25, No 1 (2025)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.99792

Abstract

The activity test of sunscreen lotion from the ethanolic extract of Artocarpus camansi leaves was carried out. The activity of sunscreen lotion as sun protecting factor (SPF) is ranging from 28.716 ± 0.1557 to 29.740 ± 0.1360, while the SPF of pure compound is 28.483 ± 0.1422. The type of lotion is water in oil (w/o) with viscosity and pH values in the range of 3057.1–5001.1 cP and 6.86–7.89, respectively. The viscosity and pH values obtained were following the standard SNI 16-4399-1996. The value of dispersion is in the range of 4.60–6.90 cm, while the value of adhesion is in the range of 14.55–25.03 s. The pure compound is thought to be γ-sitosterol by analysis of its molecular weight similarity and positive ion fragment m/z with a melting point of 147 °C. From the molecular docking, it is known that γ-sitosterol has the highest binding affinity value of −7.4 and −8.2 kcal/mol to human neutrophile collagenase (PDB ID: 1BZS) and fibroblast collagenase-1 (PDB ID: 966C), respectively. The presence of active compounds in the ethanolic extract of A. camansi lotion can support the activity of the SPF so that it can be used as a sunscreen formula. 
Antibacterial Activity Of Neem (Azadirachta indica A. Juss) Essential Oil Obtained By The Enfleuration Method Against Propionibacterium acnes Bacteria In Liquid Soap Formula Nasution, Rosnani; Bahi, Muhammad; Marianne, Marianne; Hadisah, Dara
Journal of Carbazon Vol 3, No 1 (2025): June 2025
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jocarbazon.v3i1.46643

Abstract

This research was conducted to determine the antibacterial activity of Azadirachta indica flower essential oil and its liquid soap formulation against P. acnes bacteria and to determine the quality of the liquid soap formulation. The essential oil of A. indica flower was obtained by the enfleuration method, the yield was a concentrated yellow essential oil with a yield of 2.151%, a density of 0.892 g/mL, solubility in ethanol 90%, 1:1, clear; and a refractive index of 1.435 which complies with the Indonesian National Standard (SNI). Furthermore, essential oils are formulated into liquid soap preparations and tested for physical quality and antibacterial activity. The liquid soap formulation had a distinctive odor of A. indica flowers, and homogen. The antibacterial activity against P. acnes bacteria, was the inhibitory value of A. indica flower liquid soap was higher than A. indica flower essential oil with the highest liquid soap inhibition power of 52%, while the inhibitory power of essential oil was 51% with each concentration of 2.5%, which was compared to its positive control, namely chloramphenicol. The quality testing of liquid soap is accordance with SNI 06-4085-1996, pH values ranging from 8.48 9.67 meet SNI (8-11), viscosity values ranging from 1504.4 cP 2369.7 cP meet SNI (400-4000 cPs), and foam height values ranging from 7.1 cm 8.3 cm. The results of the GC MS analysis of A. indica essential oil showed that the dominant compound was -Copaene (15.84%).
Co-Authors . Marianne Azura, Rafna Bastian, Reza Akbar Hadisah, Dara Hilda, Michelia Mutiara Maulydia, Nur Balqis Muhammad Bahi