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All Journal Indonesian Journal of Chemistry Indonesian Journal of Pharmaceutical and Clinical Research Journal Of Carbazon
Rosnani Nasution
Department of Chemistry, Syiah Kuala University
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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In Silico Investigation of γ-Sitosterol Isolated from the Ethanol Extract of Artocarpus camansi Leaves as a Sunscreen Agent Nasution, Rosnani; Azura, Rafna; Bahi, Muhammad; Maulydia, Nur Balqis; Bastian, Reza Akbar; Hilda, Michelia Mutiara; Marianne, Marianne
Indonesian Journal of Chemistry Vol 25, No 1 (2025)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.99792

Abstract

The activity test of sunscreen lotion from the ethanolic extract of Artocarpus camansi leaves was carried out. The activity of sunscreen lotion as sun protecting factor (SPF) is ranging from 28.716 ± 0.1557 to 29.740 ± 0.1360, while the SPF of pure compound is 28.483 ± 0.1422. The type of lotion is water in oil (w/o) with viscosity and pH values in the range of 3057.1–5001.1 cP and 6.86–7.89, respectively. The viscosity and pH values obtained were following the standard SNI 16-4399-1996. The value of dispersion is in the range of 4.60–6.90 cm, while the value of adhesion is in the range of 14.55–25.03 s. The pure compound is thought to be γ-sitosterol by analysis of its molecular weight similarity and positive ion fragment m/z with a melting point of 147 °C. From the molecular docking, it is known that γ-sitosterol has the highest binding affinity value of −7.4 and −8.2 kcal/mol to human neutrophile collagenase (PDB ID: 1BZS) and fibroblast collagenase-1 (PDB ID: 966C), respectively. The presence of active compounds in the ethanolic extract of A. camansi lotion can support the activity of the SPF so that it can be used as a sunscreen formula. 
Antibacterial Activity Of Neem (Azadirachta indica A. Juss) Essential Oil Obtained By The Enfleuration Method Against Propionibacterium acnes Bacteria In Liquid Soap Formula Nasution, Rosnani; Bahi, Muhammad; Marianne, Marianne; Hadisah, Dara
Journal of Carbazon Vol 3, No 1 (2025): June 2025
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jocarbazon.v3i1.46643

Abstract

This research was conducted to determine the antibacterial activity of Azadirachta indica flower essential oil and its liquid soap formulation against P. acnes bacteria and to determine the quality of the liquid soap formulation. The essential oil of A. indica flower was obtained by the enfleuration method, the yield was a concentrated yellow essential oil with a yield of 2.151%, a density of 0.892 g/mL, solubility in ethanol 90%, 1:1, clear; and a refractive index of 1.435 which complies with the Indonesian National Standard (SNI). Furthermore, essential oils are formulated into liquid soap preparations and tested for physical quality and antibacterial activity. The liquid soap formulation had a distinctive odor of A. indica flowers, and homogen. The antibacterial activity against P. acnes bacteria, was the inhibitory value of A. indica flower liquid soap was higher than A. indica flower essential oil with the highest liquid soap inhibition power of 52%, while the inhibitory power of essential oil was 51% with each concentration of 2.5%, which was compared to its positive control, namely chloramphenicol. The quality testing of liquid soap is accordance with SNI 06-4085-1996, pH values ranging from 8.48 9.67 meet SNI (8-11), viscosity values ranging from 1504.4 cP 2369.7 cP meet SNI (400-4000 cPs), and foam height values ranging from 7.1 cm 8.3 cm. The results of the GC MS analysis of A. indica essential oil showed that the dominant compound was -Copaene (15.84%).
Antibacterial Activities of Perfume: Combination Flower Magnolia alba, Cananga odorata and Mimusops elengi L, Fixed with Pogostemon cablin Oil Nasution, Rosnani; Azwar, Azalia Izdhihar; Helwati, Hira; Marianne
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 2 No. 1 (2019): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (787.644 KB) | DOI: 10.32734/idjpcr.v2i1.814

Abstract

Abstract: The making of perfume from the combination Magnolia alba (M. alba) flower oil, Cananga odorata (C. odorata) and Mimusops elengi L (M. elengi) fixed with Pogostemon cablin oil (P. cablin) have been done. Essential oil of M. alba and C. odorata was distilled by water distillation and extraction essential oil of M. elengi flower using n-hexane evaporated solvent method. Composition perfume through organoleptic test obtained with a ratio of 4% v/v, 4% v/v, and 2% v/v for each essential oil M. alba, C. odorata and M. elengi. Antibacterial activity of the perfume and each of the volatile oil was performed by the disc diffusion method. Antibacterial activity test showed that perfumes were able to inhibit the growth of Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) bacteria, but less active. Antibacterial activity of the perfume was more active against E. coli with an inhibitory zone of 8.3 mm and 39.81% inhibitory power than S. aureus bacterial 7.3 mm inhibition zone with 37.55% inhibitory power. Perfumes after storage for one, and two months had better antibacterial activity than before storage with an average inhibitory zone of 11-15 mm and inhibitory power of 50- 68,18%. Keywords: Antibacterial, E. Coli, C. Odorata, M. alba, M. elengi, P. cablin, , S. aureus
Co-Authors . Marianne Azura, Rafna Azwar, Azalia Izdhihar Bastian, Reza Akbar Hadisah, Dara Hilda, Michelia Mutiara Hira Helwati Maulydia, Nur Balqis Muhammad Bahi