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All Journal Proceedings of Annual International Conference Syiah Kuala University - Life Sciences & Engineering Chapter Journal of Pharmaceutics and Pharmacology Jurnal Pengabdian UntukMu NegeRI Abdimas Talenta : Jurnal Pengabdian Kepada Masyarakat Indonesian Journal of Chemistry Jurnal Abdimas Madani dan Lestari (JAMALI) Indonesian Journal of Pharmaceutical and Clinical Research Journal Of Carbazon

. Marianne

Universitas Sumatera Utara

Author-ID : 1363546

Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences Other

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Hepatoprotective Activity of Curcuma mangga Extract on Paracetamol-Induced Male Mice Yuandani; Silvia Mardaliza; Marianne
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 1 No. 2 (2018): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

This study was carried out to investigate the protective effect of ethanol extract of Curcuma mangga rhizomes on paracetamol-induced hepatotoxicity. High dose of paracetamol (1.35g/kg bw) was used to induce hepatic necrosis of mice liver. The male mice received ethanol extract of C. mangga rhizomes (100, 200 and 400 mg/kg BW) for 7 days. The hepatoprotective actvity of extract was compared to normal, positive (curcuma) and negative control. The liver function was evaluated by measuring the biochemistry parameters which include alanine aminotransferase (ALT) and aspartate aminotransferase (AST). In addition, histophatological study on hepatic tissue section was also carried out. The C. mangga extract displayed hepatoprotective effect except at dose of 100 mg/kg bw. The increasing of serum levels of AST and ALT were inhibited after treatment with ethanol extract at doses of 200 and 400 mg/kb bw which was comparable with normal and curcuma as postive control (p>0.05). In addition, histological assessment of hepatic tissue demonstrated no liver damage, specially at dose of 400 mg/kb BW. The result indicate that ethanol extract of C. mangga rhizomes has hepatoprotective effect, especially at doses of 200 and 400 mg/kg bw . Keywords: C. mangga, rhizomes, biochemistry parameters, histopathology

Analgesic Activity of Ethanol Extract of Temu Giring Rhizome (Curcuma heyneana Val & Zijp) in Mice Marianne; Khairunnisa; Wilda
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 1 No. 2 (2018): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Temu giring (Curcuma heyneana Val & Zijp) is a traditional medicinal plant that is believed in community as an analgesic. The objective of this research was to determine the analgesic activity of the C. heyneana rhizome by using infra red (IR) thermal induction method in mice. Mice were divided into 7 groups. Group 1 served as negative control, group 2,3,4,5 served as treatment groups which is given ethanolic extract of C. heyneana rhizome at dose of 5, 25, 125, and 625 mg/kg respectively, group 6 and 7 served as comparable groups, given antalgin 65 mg/kg and morphine sulphate 1.3 mg/kg respectively. The observation have been done, included to pain resistance of mice which exposed by infra red (IR) every 10 minutes for 80 minutes. The data were analyzed by ANOVA at the significance level of 95%. Ethanolic extract of C. heyneana at the doses of 25, 125, and 625 mg/kg had significant effect to reduce the pain compared to the negative control (p<0.05). Ethanolic extract of C. heyneana rhizome at dose of 125 mg/kg, had the same effect to antalgin 65 mg/kg (pâ‰¥0.05), while the ethanolic extract of C. heyneana at the dose of 625 mg/kg had the same effect as morphine sulfate 1.3 mg/kg (pâ‰¥0.05). It can be concluded that ethanolic extract of C. heyneana rhizome has analgesic activity. Keywords: temu giring, analgesic, Curcuma heyneana, rhizome

STIMULASI WIRAUSAHA PADA MURID SEKOLAH MENENGAH ATAS DI TANJUNG PURA LANGKAT SUMATERA UTARA MELALUI WORKSHOP PEMBUATAN LOSION ANTI NYAMUK BERBASIS HERBAL Yuandani1; Marianne; Popi Patilaya
ABDIMAS TALENTA: Jurnal Pengabdian Kepada Masyarakat Vol. 2 No. 1 (2017): ABDIMAS TALENTA: Jurnal Pengabdian Kepada Masyarakat
Publisher : Talenta Publisher

SMA N 1 Tanjung Pura dan SMA Swasta Samanhudi terletak di kecamatan Tanjung Pura, Kabupaten Langkat, Provinsi Sumatera Utara. Kecamatan Tanjung Pura di Kabupaten Langkat merupakan salah satu kecamatan dengan tingkat kesejahteraan yang belum memadai. Sebahagian besar masyarakat bekerja sebagai petani dan nelayan, dan umumnya mereka belum dapat memenuhi biaya hidup yang memadai dan gagal dalam menguasai potensi produktif yang tersedia. Salah satu cara yang dapat dilakukan adalah diversifikasi pekerjaan dengan menstimulasi jiwa wirausaha generasi muda di Tanjung Pura, antara lain dengan memberikan keterampilan khusus yang nantinya bisa dimanfaatkan oleh mereka untuk membuka usaha sendiri. Salah satu cara yang akan dilakukan adalah dengan memberikan workshop pembuatan losion anti nyamuk. Hal ini mengingat kecamatan Tanjung Pura memiliki prevalensi yang tinggi terhadap penyakit malaria dan demam berdarah dengue (DBD), sehingga sangat tepat untuk mengajarkan para siswa SMA dalam pembuatan losion anti nyamuk agar dapat turut serta menurunkan angka kejadian penyakit tersebut. Oleh sebab itu,tujuan umum program pengabdian pada masyarakat ini adalah meningkatkan minat berwirausaha pada murid sekolah menengah atas, menurunkan angka pengangguran dan angka penyebaran penyakit malaria dan DBD di Kecamatan Tanjung Pura. Target utama dari program ini adalah sekelompok masyarakat yang memiliki latar pendidikan terakhir golongan menengah atau setara yang berada di Kecamatan Tanjung Pura. Secara khusus, program ini bertujuan untuk melatih siswa-siswi setingkat SMA yang ada di SMAN 1 Tanjung Pura dan SMA Swasta Samanhudi dalam berwirausaha untuk memproduksi losion anti nyamuk yang berbahan dasar minyak sereh.

Sosialisasi Langkah Cuci Tangan Yang Benar Guna Mewujudkan Masyarakat Sehat Di Sman 2 Sibolga Sumaiyah Sumaiyah; Marianne Marianne; Embun Suci Nasution; Dewi Pertiwi; Sony Eka Nugraha
Jurnal Pengabdian UntukMu NegeRI Vol 4 No 1 (2020): Pengabdian Untuk Mu negeRI
Publisher : LPPM UMRI

Washing hands is a simple step that can be improve the level of health of oneself, family and community. World Health Organization (WHO) has provided rules regarding good and proper washing steps, whereby the Indonesian government is promoting its socialization especially in the school environment. Senior High School (SMA) Negeri 2 Sibolga is one of the randomly selected schools to carry out the right hand washing step socialization according to WHO. The level of student’s knowledge about the correct steps for washing hands has been shown increase after socialization.

β-Sitosterol From Bark Of Artocarpus Camansi And Its Antidiabetic Activity Rosnani Nasution; . Marianne; Muhammad Bahi; Nurdin Saidi; Isni Junina
Proceedings of The Annual International Conference, Syiah Kuala University - Life Sciences & Engineering Chapter Vol 5, No 1 (2015): Engineering
Publisher : Syiah Kuala University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (145.187 KB)

Research compound betasitosterol from the bark of plant of Artocarpus camansi (kulu) and test its antidiabetic has been done. The study begins by extracting samples (3.5 kg),w in the solvent of hexane, hexane extracts obtained,then separated by gravity column chromatography, and was characterized by GC-MS. The results obtained are groups of fractions A, and B. From phytochemical test results, the fraction of group B, has a steroid framework. Group fractions B after rechromatographed is obtained a pure isolates of B. Characterization by 1H-NMR and MS (from GC-MS), pure isolate of B is β-sitosterol. Antidiabetic activity test results showed that the extract of n-hexane, fraction group A and fraction group of B (containing βsitosterol), can lower blood sugar levels male Swiss Webster mice were performed by the method of glucose tolerance. Dose of extract of n-hexane is 50 mg/dL at minute 30th, 60th and 90th can lower glucose as much as 103 mg/dL; 71 mg/dL; and 49.33 mg/dL. Group of fraction A of a dose 50 mg/dL at 60th minutes and 90th can lower blood glucose of mice are: 116 mg/dL; and 58 mg/dL. Group B fraction (containing β-sitosterol) at a dose of 50 mg/dL at minute 30th, 60th and 90th can lower glucose by 73 mg/dL; 87 mg/dL; and 73.33 mg/dL. Group fraction of B is the highest in lowering blood glucose average compared with n-hexane extract and group A. Analysis of variance of this fraction were performed by using ANOVA Post hoc analysis procedures one-way of, significant differences (p0.05) and (p 0.01) conducted using Tukey.

Didekilketon compounds from the leaves of Artocarpus camansi Blanco Rosnani Nasution; . Marianne
Proceedings of The Annual International Conference, Syiah Kuala University - Life Sciences & Engineering Chapter Vol 3, No 1 (2013): Life Sciences
Publisher : Syiah Kuala University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (215.151 KB)

Research on plant leaves Artocarpus camansi (kulu), aims to determine the chemical compounds contained in the hexane extract of the plant leaves. This study begins by isolating the hexane extract, from the leaves of plants A. camansi. Subsequently the extracts were characterized by GC-MS, to determine the fragmentation pattern softhe compunds contained in leaves of A. camansi. Furthermore the hexane extract further fractionated to obtain pure isolates. Pure isolate of the compound as white solid with a melting point of176-1780C. Characterized to the pure compound with1H-NMR, 13C-NMR, DEPT and reinforced with HSQC, and HMBC, expressed asdidekilketon (C21H42O).

Penghambatan Degranulasi Mastosit Tersensitisasi Aktif oleh Curcuma Mangga Val. & Zijp Pada Mencit Secara In Vitro Fany Alvianty; Rasmadin Mukhtar*; Marianne Marianne
Journal of Pharmaceutics and Pharmacology Vol 1, No 1 (2012)
Publisher : Journal of Pharmaceutics and Pharmacology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (214.105 KB)

Background: Mastocyte widely recognized as critical effector cell in immune response is responsible for the occurrence of allergic reaction mediated by Imunoglobulin E (IgE). Mango ginger is a plant that the rhizome has an activity as antiallergy. Objective: To evaluate the effect of C. mangga rhizome ethanolic extract on the inhibition of active sensitized mastocyte degranulation of male mice in vitro. Methods: The inhibitory effect of mastocyte degranulation by Curcuma mangga was determined by calculating the number of mast cell which was not degranulated, derived from mice intraperitoneal fluid that were isolated, using hemocytometer. Before the test was taken, cell viability test had carried out to evaluate the citotoxicity of plant extract toward mastocytes. Results: The result showed that the ability of C. mangga dose 400 µg/ml showed percent of mast cell degranulation was smaller (30.18%) than C. mangga dose 200 µg/ml (42.76%), dose 100 µg/ml (55.76%), dose 50 µg/ml (75.85%), and dose 25 µg/ml (84.74%). It showed a relationship between dose excalation and percent of mastocyte degranulation that the increasing in dose will decrease the degranulation of mastocyte. Conclusion: C. mangga ethanolic extract can be used as antiallergic associated to the effect in decrease degranulation of active sensitized mastocyte. Keywords: degranulation, mastocyte, in vitro, Curcuma mangga Val. &Zijp ABSTRAK Latar belakang: Mastosit secara luas dianggap sebagai sel efektor penting dalam respon imun yang bertanggung jawab atas terjadinya reaksi alergi yang dimediasi oleh Imunoglobulin E (IgE). Curcuma mangga (temu mangga) merupakan salah satu tumbuhan yang rimpangnya diduga memiliki aktivitas sebagai antialergi. Tujuan: Untuk melihat pengaruh ekstrak etanol rimpang temu mangga terhadap penghambatan degranulasi mastosit yang tersensitisasi aktif pada mencit jantan secara in vitro. Metode: Efek penghambatan degranulasi mastosit oleh Curcuma mangga ditentukan dengan menghitung jumlah mastosit yang tidak terdegranulasi, yang berasal dari cairan intraperitoneal mencit yang diisolasi, menggunakan alat hemositometer. Sebelum dilakukan pengujian penghambatan degranulasi mastosit oleh C. mangga, dilakukan uji ketahanan sel (viability) untuk mengevaluasi sitotoksisitas ekstrak tanaman terhadap mastosit. Hasil: Hasil penelitian menunjukkan bahwa kemampuan C. mangga dosis 400 µg/ml menunjukkan persen degranulasi mastosit yang lebih kecil yaitu 30,18% dibandingkan dengan C. mangga dosis 200 µg/ml (42,76%), dosis 100 µg/ml (55,76%), dosis 50 µg/ml (75,85%), 25 µg/ml (84,74%). Hal ini menunjukkan bahwa adanya hubungan antara peningkatan dosis dengan persen degranulasi mastosit yaitu semakin besar peningkatan dosis maka mastosit yang terdegranulasi juga akan semakin sedikit. Kesimpulan: Ekstrak etanol C. mangga dapat digunakan sebagai anti alergi terkait dengan pengaruhnya dalam menurunkan degranulasi mastosit yang tersensitisasi aktif. Kata Kunci: degranulasi, mastosit, in vitro, Curcuma mangga Val. & Zijp

Isolation of Ethyl p-Methoxycinnamate from Azadirachta indica Root Bark as Hong Kong Caterpillar (Tenebrio molitor) Antifeedant Rosnani Nasution; Cut Nyak Candein; Nurdin Saidi; Muhammad Bahi; Marianne Marianne
Indonesian Journal of Chemistry Vol 21, No 6 (2021)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.64487

This study aims to identify the antifeedant activity of Azadirachta indica A. Juss root bark against Hong Kong caterpillar (Tenebrio molitor). A. indica A. root was macerated in n-hexane, ethyl acetate, and methanol. The investigation of antifeedant activity was conducted by using the no choice leaf disk method. The antifeedant activity (%AI) tests showed that the extracts of n-hexane, ethyl acetate, and methanol with each concentration of 0.5% were 6.71, 71.78, and 40.14%, respectively. The ethyl acetate extract demonstrated the most active antifeedant activity. Ethyl acetate extract was fractionated to obtain five subfractions (A-E). Each subfraction with each concentration of 0.5% showed the %AI of 70.55, 85.29; 67.40, 82.70 and 82.22%, respectively. Furthermore, GC-MS results demonstrated that ethyl acetate extract contained 19 compounds. The main compounds are methyl hexadecanoate and methyl 8-octadecenoate. Further purification of fraction A, which has the highest amount, was then carried out. The obtained isolate, i.e., A32, was determined as ethyl p-methoxycinnamate confirmed by 13C- and 1H-NMR, FTIR, and MS spectra. The presence of ethyl p-methoxycinnamate makes A. indica A. root is potential as T. molitor antifeedant. The implication of these findings is to reference herbal antifeedants and reduce the use of synthetic pesticides.

In Silico Investigation of γ-Sitosterol Isolated from the Ethanol Extract of Artocarpus camansi Leaves as a Sunscreen Agent Nasution, Rosnani; Azura, Rafna; Bahi, Muhammad; Maulydia, Nur Balqis; Bastian, Reza Akbar; Hilda, Michelia Mutiara; Marianne, Marianne
Indonesian Journal of Chemistry Vol 25, No 1 (2025)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.99792

The activity test of sunscreen lotion from the ethanolic extract of Artocarpus camansi leaves was carried out. The activity of sunscreen lotion as sun protecting factor (SPF) is ranging from 28.716 ± 0.1557 to 29.740 ± 0.1360, while the SPF of pure compound is 28.483 ± 0.1422. The type of lotion is water in oil (w/o) with viscosity and pH values in the range of 3057.1–5001.1 cP and 6.86–7.89, respectively. The viscosity and pH values obtained were following the standard SNI 16-4399-1996. The value of dispersion is in the range of 4.60–6.90 cm, while the value of adhesion is in the range of 14.55–25.03 s. The pure compound is thought to be γ-sitosterol by analysis of its molecular weight similarity and positive ion fragment m/z with a melting point of 147 °C. From the molecular docking, it is known that γ-sitosterol has the highest binding affinity value of −7.4 and −8.2 kcal/mol to human neutrophile collagenase (PDB ID: 1BZS) and fibroblast collagenase-1 (PDB ID: 966C), respectively. The presence of active compounds in the ethanolic extract of A. camansi lotion can support the activity of the SPF so that it can be used as a sunscreen formula.

FORMULASI SEDIAAN MASKER GEL PEEL-OFF KOPI ROBUSTA (Coffea canephora) DAN EFEKTIVITASNYA SEBAGAI ANTI PENUAAN DINI Hanum, Tengku Ismanelly; Marianne, Marianne; Sumaiyah, Sumaiyah; Hasibuan, Poppy Anjelisa Zaitun; Hasibuan, Wan Fadilla; Bestari, Khansa Candra
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 8 No. 01 (2025): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v8i01.19940

Robusta coffee (Coffea canephora) contains several components that are good for facial skin, such as flavonoids which act as antioxidants. A peel-off gel mask is a skin care cosmetic preparation in the form of a gel and after being applied to the skin for a certain time until it dries, this preparation will form an elastic transparent film layer, so that it can be peeled off. This research aims to develop Robusta coffee into a peel-off gel mask preparation. off off which has appearance, pH, viscosity, spreadability, drying time, and its effectiveness as an anti-aging agent. The research stages carried out were the formulation of a 10% coprobusta peel-off gel mask, stability testing at room temperature for 12 weeks and the anti-aging effectiveness of the 10% corobusta peel-off gel mask. Stability test parameters include pH, viscosity, spreadability, and drying time. Test the effectiveness of anti-aging using a skin analysis tool with test parameters, namely air content, smoothness, pore size, number of blemishes and wrinkles. The results of this study show that the preparation is stable in all test parameters for 12 weeks of storage at room temperature, does not irritate the skin and has anti-aging activity on facial skin, namely increasing air content, smoother skin, smaller pores, reducing the number of blemishes and wrinkles over time. four weeks of treatment.

Co-Authors Azura, Rafna Bastian, Reza Akbar Bestari, Khansa Candra Cut Nyak Candein Dewi Pertiwi Eka Nugraha, Sony Embun Suci Nasution Fany Alvianty Hadisah, Dara Hanum, Tengku Ismanelly Hasibuan, Poppy Anjelisa Zaitun Hasibuan, Wan Fadilla Henny Sri Wahyuni Hilda, Michelia Mutiara Isni Junina Khairunnisa Lia Laila, Lia Maulydia, Nur Balqis Muhammad Bahi Muhammad Bahi Muhammad Bahi Nurdin Saidi Nurdin Saidi Popi Patilaya Prasetyo, Bayu Eko Rasmadin Mukhtar Rosnani Nasution Rosnani Nasution Rosnani Nasution Rosnani Nasution Silvia Mardaliza Sumaiyah Sumaiyah Sumaiyah, Sumaiyah Wilda Yuandani Yuandani

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