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All Journal Folia Medica Indonesiana Indonesian Journal of Rheumatology Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Majalah Biomorfologi (Biomorphology Journal)
Yuliasih Yuliasih
Department Of Internal Medicine, Faculty Of Medicine, Universitas Airlangga, Surabaya
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience Public Health Other

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Cytokines, Autoantibodies, and Complements in Active Systemic Lupus Erythematosus Patients from Javanese Population Yuliasih Yuliasih; Lita Diah Rahmawati; Putu Ayu Niken Amrita; Setiati Widyaningrum; Dodi Kriswanto
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 26, No 3 (2020)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v26i3.1549

Abstract

Systemic Lupus Erythematosus (SLE) is an autoimmune disease that has various clinical manifestations. The SLE pathogenesis involves both innate and adaptive immunological components. The system is essentially determined by genetic factors that control certain clinical and serological manifestations. Genetic traits that determine the roles of cytokines, autoantibodies, and complements in SLE vary among ethnicities. The roles of TNF-α, IL-6, anti-C1q, anti-dsDNA, C3, and C4 towards SLE activity need to be evaluated in the Javanese population. This study aimed to determine the correlation of TNF-α, IL-6, anti-C1q antibodies, anti-dsDNA, C3, and C4 with SLE activity. Forty SLE patients were diagnosed based on the American College of Rheumatology (ACR) criteria. Disease activity was measured by the Systemic Lupus Activity Measure (SLAM) index. TNF-α, IL-6, Anti-C1q, and anti-dsDNA levels were measured by ELISA, while MINIMEPH measured C3 and C4. Thirty-nine female and one male patient with SLE were diagnosed according to ACR criteria. The mean of SLAM score, anti-dsDNA, C3, and C4 levels was 20.98±6.7, 224.96±298.6, 68.70±37.08 mg/dL, and 18.75±10.69 mg/dL, respectively. Spearman's correlation test showed a positive correlation between TNF-α (r = 0.971, p<0.001), IL-6 (r=0.835, p<0.001), anti-C1q (r=0.399, p=0.01), and disease activity (SLAM score) by using. The linear regression test for TNF-α, IL-6, anti-C1q, and SLAM showed the strongest association for TNF-α (r=0.891, p<0.000). TNF-α, IL-6, and anti-C1q were correlated to disease activity in SLE patients from the Javanese population.
Systemic sclerosis and hyperthyroidism in pregnancy Awalia Awalia; Yuliasih Yuliasih; Joewono Soeroso
Indonesian Journal of Rheumatology Vol. 4 No. 1 (2013): Indonesian Journal of Rheumatology
Publisher : Indonesian Rheumatology Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (216.305 KB) | DOI: 10.37275/ijr.v4i1.89

Abstract

Systemic sclerosis (SSc) is a connective tissue disease affecting women of childbearing age at least five times more than men. For a long time, pregnant women with SSc have high morbidity and mortality based on case reports and case series. Therefore, the disease was a contraindication for pregnancy. However, current retrospective studiesshow that despite of an increased frequency of prematurity and small for gestational age infants, overall maternal and neonatal survival is good. With close monitoring and appropriate therapy, most scleroderma patients can sustain a successful pregnancy.
IL-17 and Disease Activity in Spondyloarthitis Yuliasih; Yusdeny Lanasakti
Folia Medica Indonesiana Vol. 57 No. 4 (2021): December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1199.684 KB) | DOI: 10.20473/fmi.v57i4.22073

Abstract

Highlight:The correlation of IL-17 to disease activity by The Ankylosing Spondylitis Disease Activity Score C-Reactive Protein (ASDAS-CRP) was identified. IL-17 level is strongly correlated to disease activity in SpA patients. Abstract:IL-17 is a new cytokine involved in the pathogenesis of Spondyloarthritis (SpA). Recent studies show that IL-17 level correlates to disease activity, and it is used as a basis in treating SpA patients who do not respond to anti-TNF-α. This study identified the correlation of IL-17 to disease activity measured by The Ankylosing Spondylitis Disease Activity Score C-Reactive Protein (ASDAS-CRP). This study was a cross-sectional study involving SpA patients according to the 2009 ASAS criteria in Dr. Soetomo General Academic Hospital, Surabaya. Disease activity and IL-17 level were analyzed using Spearman correlation test to see the strength of correlation. Forty SpA patients showed mean age of 53.58 ± 9.28 years with a body mass index of 24.36 ± 3.23 kg/m2, ESR of 39.50 ± 18.76 mm/hour, clinically obtained Schober Test of 13.11 ± 1.22 cm, chest extension test of 1.45 ± 0.77 cm, and tragus-to-wall test 13.53 ± 1.99 cm. The median CRP and IL-17 were 0.3 (0.10-5.70) mg/dL and 9.30 (7.70-13.60) pg/dL, respectively. Based on the ASDAS-CRP system, the patients showed disease activities that fall into the category was high (62.5%), moderate (35%), and inactivity (2.5%). IL-17 level is strongly correlated to disease activity in SpA patients (p=0.000, r = 0.711).
Cytokines, Autoantibodies, and Complements in Active Systemic Lupus Erythematosus Patients from Javanese Population Yuliasih Yuliasih; Lita Diah Rahmawati; Putu Ayu Niken Amrita; Setiati Widyaningrum; Dodi Kriswanto
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 26 No. 3 (2020)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v26i3.1549

Abstract

Systemic Lupus Erythematosus (SLE) is an autoimmune disease that has various clinical manifestations. The SLE pathogenesis involves both innate and adaptive immunological components. The system is essentially determined by genetic factors that control certain clinical and serological manifestations. Genetic traits that determine the roles of cytokines, autoantibodies, and complements in SLE vary among ethnicities. The roles of TNF-α, IL-6, anti-C1q, anti-dsDNA, C3, and C4 towards SLE activity need to be evaluated in the Javanese population. This study aimed to determine the correlation of TNF-α, IL-6, anti-C1q antibodies, anti-dsDNA, C3, and C4 with SLE activity. Forty SLE patients were diagnosed based on the American College of Rheumatology (ACR) criteria. Disease activity was measured by the Systemic Lupus Activity Measure (SLAM) index. TNF-α, IL-6, Anti-C1q, and anti-dsDNA levels were measured by ELISA, while MINIMEPH measured C3 and C4. Thirty-nine female and one male patient with SLE were diagnosed according to ACR criteria. The mean of SLAM score, anti-dsDNA, C3, and C4 levels was 20.98±6.7, 224.96±298.6, 68.70±37.08 mg/dL, and 18.75±10.69 mg/dL, respectively. Spearman's correlation test showed a positive correlation between TNF-α (r = 0.971, p<0.001), IL-6 (r=0.835, p<0.001), anti-C1q (r=0.399, p=0.01), and disease activity (SLAM score) by using. The linear regression test for TNF-α, IL-6, anti-C1q, and SLAM showed the strongest association for TNF-α (r=0.891, p<0.000). TNF-α, IL-6, and anti-C1q were correlated to disease activity in SLE patients from the Javanese population.
PATTERN OF RHEUMATIC DISEASES IN THE DIVISION OF RHEUMATOLOGY, DR. SOETOMO GENERAL ACADEMIC HOSPITAL, SURABAYA, INDONESIA, BETWEEN NOVEMBER 2021 AND MARCH 2022 Afifur Rafi Hilmi Aziz; Yuliasih; Imam Subadi
Majalah Biomorfologi Vol. 33 No. 2 (2023): MAJALAH BIOMORFOLOGI
Publisher : Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mbiom.v33i2.2023.82-91

Abstract

Highlights: Rheumatic diseases, like many others, are often misdiagnosed and treated late in life, resulting in the increase of rheumatic diseases incidence. Gender, age, level of education, and occupation all play crucial roles in the onset of rheumatic disorders. Abstract Background: The epidemiology of rheumatic diseases plays an important role in the spread of rheumatic diseases worldwide. Epidemiology data of rheumatology diseases in Dr. Soetomo General Academic Hospital remains unclear as there are some problems such as rheumatic drug depletion and imperfect medical recording.  Objective: This study aimed to analyze the pattern of rheumatic diseases at the Division of Rheumatology, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia.  Material and Method: This prospective descriptive study used secondary data from medical records between November 2021 and March 2022 at the Division of Rheumatology, Dr. Soetomo General Academic Hospital. The variables of this study were gender, age, occupation, education level, disease duration, and clinical manifestations. Results: Secondary data was provided by 109 patients in this study. Gender was dominated by women as much as 96 (88%), age was dominated by age groups 26-35 years and 46-55 years, each as much as 26 (23.8%), educational level was dominated by senior high school as much as 24 (22%), and employment was dominated by housewives as much as 39 (35.7%) in the Divison of Rheumatology, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia. Based on disease incidence, 42 patients (38.5%) had systemic lupus erythematosus, and 38 patients (34.8%) had ankylosing spondylitis. Conclusion: Rheumatology patients at Dr. Soetomo General Academic Hospital Surabaya are predominantly female, aged 26-55, with senior high school education. The diseases mostly affect housewives and have a higher frequency of systemic lupus erythematosus and ankylosing spondylitis.
Co-Authors Afifur Rafi Hilmi Aziz Awalia Awalia Dodi Kriswanto Imam Subadi Joewono Soeroso Putu Ayu Niken Amrita Setiati Widyaningrum Sosialita, Tiara Diah Yusdeny Lanasakti