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REFLEKSI PRAKTIKUM KIMIA ORGANIK CALON PENDIDIK KIMIA MENGGUNAKAN REKAMAN VIDEO eko yuliyanto; Yosef Wijoyo; Enade Perdana Istyastono; Fitria Fatichatul Hidayah
JURNAL PENDIDIKAN SAINS UNIVERSITAS MUHAMMADIYAH SEMARANG Vol 6, No 2 (2018): JURNAL PENDIDIKAN SAINS UNIVERSITAS MUHAMMADIYAH SEMARANG
Publisher : Pendidikan Kimia Unimus

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/jps.6.2.2018.76-83

Abstract

Organic chemistry is one of the courses that must be taken by a pre-service teacher. However, not all students like the subject, on the other hand they have to learn. Practicum of Organic chemistry  has been carried out for some time by chemistry education students. Therefore to bridge the gap and problems. It needs to be an improvement to find out the problem. Therefore it is necessary to reflect on organic chemistry practicum using videos. This research was in the form of observation of learning organic chemistry which was participated by 29 semester 3 chemistry education students with acetic acid synthesis material, saponification and synthesis of butyl acetate. Based on the results of the study concluded that 1). It is important to prepare students' skills in using equipment 2). Practical topics getting closer to everyday products, will be more interesting, 3).Preliminary confirmation before practicum is important to ensure student readiness, 4). Reflection is very helpful in reminding lecturers of the results of learning objectives.
Caffeine and Caffeic Acid as Acetylcholinesterase Inhibitors: In Silico Perspectives Stephanus Satria Wira Waskitha; Bonifacius Ivan Wiranata; Julyus Jason Mark; Herluin Sekar Krisantia; Natalia Kristina; Glory Ivana Ardine; Chrisologus Ivan Prasetyo; Michael Raharja Gani; Florentinus Dika Octa Riswanto; Enade Perdana Istyastono
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 2 (2025)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.009687

Abstract

Alzheimer's disease (AD) has been recognized as a significant issue affecting population health globally and tended to increase over the years. The utilization of natural products for AD treatments has been widely studied, which possibly offers better outcomes with minimum side effects. Coffee consumption has been subjected as a lifestyle propensity, which offers beneficial advantages including reducing the risk of AD. Bioactive natural compounds contained in coffee such as caffeine and caffeic acid have been experimentally proven to be acetylcholinesterase (AChE) inhibitors, a pivotal target enzyme for AD treatments. This research aimed to explore the dynamics interactions of caffeine and caffeic acid in the AChE active site using the in silico approach. In this study, 100 redocking and docking simulations were implemented before the molecular dynamics (MD) simulations. The 55-ns MD simulations of huprine X, caffeine, and caffeic acid were implemented to study the dynamics interactions. Conformational stability, free energies of binding, and interaction hotspots were identified during the simulations. Our findings informed that caffeine interacted in the active site during the simulations, revealing the importance of the imidazole ring in maintaining the interactions. In contrast, caffeic acid interacted longer in the plausible allosteric site, forming ionic, hydrogen bonds, and aromatic interactions.
Co-Authors Bonifacius Ivan Wiranata Chrisologus Ivan Prasetyo Eko Yuliyanto Fitria Fatichatul Hidayah Florentinus Dika Octa Riswanto Glory Ivana Ardine Herluin Sekar Krisantia Julyus Jason Mark Michael Raharja Gani Natalia Kristina Stephanus Satria Wira Waskitha Yosef Wijoyo