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All Journal Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Journal of Agromedicine and Medical Sciences
Nugraha Wahyu Cahyana Nugraha Wahyu Cahyana
Ophthalmology Department, Faculty Of Medicine, University Of Jember, Indonesia
Health Professions Immunology & microbiology Neuroscience

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Amplitudo of accommodation in the many types of myopia Nugraha Wahyu Cahyana, Nugraha Wahyu Cahyana
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 33, No 02 (2001)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (123.05 KB)

Abstract

Background: It has been discussed among ophthalmologists whether myopia is caused by environmental factors or hereditary. One of the environmental factors is the demand of work requiring frequent and close inspection with the eyes. Myopia may develop in eyes as an adaptation to reduce demands of physical type of work.Objective: To evaluate the difference of amplitudo of accommodation in many types of myopia, and the relation between amplitudo of accommodation and the degree of myopia.Methods: Subjects of the study were myopic patients in the Eye Polyclinic of Dr. Sardjito General Hospital, Yogyakarta from November 1,2000 to March 31, 2001. Subjects were divided into 4 groups: mild, moder-ate, high, and progressive myopia. Amplitudo of accommodation was examined with spherical minus method. Sex, age, family history, occupation, education level, and onset of myopia were registered, tabu-lated and analysed.Results: The subjects of the study consisted of 64 myopia patients: 16 mild myopic patients, 16 moderate myopic patients, 16 high myopic patients, and 16 progressive myopic patients. The average amplitudo o accommodation in the mild myopia group was 6.66 ± 1.28 D; the moderate myopia group was 5.03 ± 1.117 D; the high myopia group was 3.53 ± 0.59 D, and the progressive myopia was 2.89 ± 1.14 D. There was a significant difference for each group (p<0,001). There were negative significant correlations (r = -0,758) between the amplitudo of accommodation and the degree of myopia.Conclusion: There was a difference in amplitudo of accommodation for each group of myopia. There was a negative correlation between amplitudo of accommodation and the degree of myopia.Keywords : amplitudo of accommodation - degree of myopia - negative correlation - adaptation mechanism - hereditary factor 
Amplitudo of accommodation in the many types of myopia Nugraha Wahyu Cahyana Nugraha Wahyu Cahyana
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 33, No 02 (2001)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (123.05 KB)

Abstract

Background: It has been discussed among ophthalmologists whether myopia is caused by environmental factors or hereditary. One of the environmental factors is the demand of work requiring frequent and close inspection with the eyes. Myopia may develop in eyes as an adaptation to reduce demands of physical type of work.Objective: To evaluate the difference of amplitudo of accommodation in many types of myopia, and the relation between amplitudo of accommodation and the degree of myopia.Methods: Subjects of the study were myopic patients in the Eye Polyclinic of Dr. Sardjito General Hospital, Yogyakarta from November 1,2000 to March 31, 2001. Subjects were divided into 4 groups: mild, moder-ate, high, and progressive myopia. Amplitudo of accommodation was examined with spherical minus method. Sex, age, family history, occupation, education level, and onset of myopia were registered, tabu-lated and analysed.Results: The subjects of the study consisted of 64 myopia patients: 16 mild myopic patients, 16 moderate myopic patients, 16 high myopic patients, and 16 progressive myopic patients. The average amplitudo o accommodation in the mild myopia group was 6.66 ± 1.28 D; the moderate myopia group was 5.03 ± 1.117 D; the high myopia group was 3.53 ± 0.59 D, and the progressive myopia was 2.89 ± 1.14 D. There was a significant difference for each group (p<0,001). There were negative significant correlations (r = -0,758) between the amplitudo of accommodation and the degree of myopia.Conclusion: There was a difference in amplitudo of accommodation for each group of myopia. There was a negative correlation between amplitudo of accommodation and the degree of myopia.Keywords : amplitudo of accommodation - degree of myopia - negative correlation - adaptation mechanism - hereditary factor 
In silico Test Proteolytic Potential of Papain and Zingibain Enzymes Against Protein Forming Congenital and Senilis Cataracts Gangsar Lintas Damai; Nugraha Wahyu Cahyana; Ayu Munawaroh Aziz
Journal of Agromedicine and Medical Sciences Vol 8 No 1 (2022)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v8i1.23324

Abstract

Abstract Phacoemulsification is cataract therapy’s gold standard with lowest complication rate and best visual outcome. However, phacoemulsification is expensive and difficult to use widely. Pathogenesis of cataract related to Crystalline P23T γD protein in congenital cataracts and β-amyloid protein in senile cataract. Papain enzymes and zingibain enzymes are cataract’s alternatives therapy with proteolytic effects that potentially lyse these proteins. Proteolytic injection with 30-gauge needle results in small, safe incision. Papain enzyme from Carica Papaya plant and zingibain enzyme from Zingiber Officinale plant which grows plentifully in Indonesia that becomes cheap source of proteolytic. This study’s purpose is to compare probability of binding energy based on Binding Interaction Model (BIM) between papain and zingibain enzymes against Crystalline P23T γD protein and β-amyloid protein with molecular docking. This research uses https://cluspro.bu.edu./login.php. BIM with lowest binding energy has most stable bond. Docking results show interaction probability between papain enzyme and Crystalline P23T γD protein has lowest binding energy of -730.4 kJ/mol at BIM 1. Probability of interaction between papain enzyme and β-amyloid protein has lowest binding energy of -697.2 kJ/mol at BIM 1. Probability of interaction between the enzyme zingibain and the crystalline P23T protein γD has lowest binding energy of -890.5 kJ/mol at BIM 2. Probability of interaction between the enzyme zingibain and the β-amyloid protein has lowest binding energy of -873.5 kJ/mol at BIM 0. It was concluded that the zingibain enzyme has the most stable probability of forming a stable bond to Crystalline P23T γD protein and β-amyloid protein. Keyword:In silico, papain, zingibain, cataract
Co-Authors Aziz, Ayu Munawaroh Gangsar Lintas Damai