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All Journal Indonesian Journal of Urology Journal of Biomedicine and Translational Research Journal of Agromedicine and Medical Sciences Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Jurnal Penelitian Pendidikan IPA (JPPIPA) Warta Pengabdian Jurnal Kreativitas PKM Jambura Edu Biosfer Journal Jurnal Respirologi Indonesia Majalah Kedokteran Andalas Jurnal Kesehatan Indonesian Journal of Global Health research ABDIMAYUDA: Indonesian Journal of Community Empowerment for Health Jurnal Kesehatan dr. Soebandi
Aziz, Ayu Munawaroh
Laboratorium Histologi Fakultas Kedokteran Universitas Jember
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Earth & Planetary Sciences Education Health Professions Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health

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HYPERTENSION EFFECTS ON THE DECREASED KIDNEY FUNCTION PROGRESIVITY IN BENIGN PROSTATIC HYPERPLASIA PATIENTS Dhiemas Trisyuananda Eniestama; Aziz, Ayu Munawaroh; Wahyudi, Septa Surya
Indonesian Journal of Urology Vol 28 No 1 (2021)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v28i1.660

Abstract

Objective: A comprehensive knowledge about BPH and hypertension is needed to reduce morbidity and mortality in patients with decreased kidney function due to the two diseases. Material & Methods: This research used the observational analytics method with cross-sectional design. This research used secondary data from medical records of BPH patients in Bina Sehat Hospital and Paru Hospital from January 1st to December 1st 2019. Results: Comparative serum creatinine test results in hypertensive BPH patients with non-hypertensive BPH patients using the Mann Whitney test, obtained p= 0.000. Based on these results it can be concluded that there are significant differences in serum creatinine between hypertensive BPH patients and non-hypertensive BPH patients. Correlation test results using the Spearman test between serum creatinine with blood pressure systole and diastole all samples obtained each p= 0.000 r= 0.399 for systolic blood pressure and p= 0.000 r= 0.337 for diastole blood pressure. Based on these results it can be concluded that there is a significant correlation between serum creatinine with systolic and diastolic blood pressure of the patient. Conclusion: Hypertension will worsen the kidney function decline in BPH patients seen from an increase in serum creatinine.
In silico Test Proteolytic Potential of Papain and Zingibain Enzymes Against Protein Forming Congenital and Senilis Cataracts Gangsar Lintas Damai; Nugraha Wahyu Cahyana; Ayu Munawaroh Aziz
Journal of Agromedicine and Medical Sciences Vol 8 No 1 (2022)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v8i1.23324

Abstract

Abstract Phacoemulsification is cataract therapy’s gold standard with lowest complication rate and best visual outcome. However, phacoemulsification is expensive and difficult to use widely. Pathogenesis of cataract related to Crystalline P23T γD protein in congenital cataracts and β-amyloid protein in senile cataract. Papain enzymes and zingibain enzymes are cataract’s alternatives therapy with proteolytic effects that potentially lyse these proteins. Proteolytic injection with 30-gauge needle results in small, safe incision. Papain enzyme from Carica Papaya plant and zingibain enzyme from Zingiber Officinale plant which grows plentifully in Indonesia that becomes cheap source of proteolytic. This study’s purpose is to compare probability of binding energy based on Binding Interaction Model (BIM) between papain and zingibain enzymes against Crystalline P23T γD protein and β-amyloid protein with molecular docking. This research uses https://cluspro.bu.edu./login.php. BIM with lowest binding energy has most stable bond. Docking results show interaction probability between papain enzyme and Crystalline P23T γD protein has lowest binding energy of -730.4 kJ/mol at BIM 1. Probability of interaction between papain enzyme and β-amyloid protein has lowest binding energy of -697.2 kJ/mol at BIM 1. Probability of interaction between the enzyme zingibain and the crystalline P23T protein γD has lowest binding energy of -890.5 kJ/mol at BIM 2. Probability of interaction between the enzyme zingibain and the β-amyloid protein has lowest binding energy of -873.5 kJ/mol at BIM 0. It was concluded that the zingibain enzyme has the most stable probability of forming a stable bond to Crystalline P23T γD protein and β-amyloid protein. Keyword:In silico, papain, zingibain, cataract
The Protection Effect Of Methanol Extract From Asam Jawa Seed On Testicular Tissue Damage Induced By Aluminium Chloride (AlCL3) Rena Normasari; Muhammad Iqbal Fauzi; Ayu Munawaroh Aziz
Journal of Agromedicine and Medical Sciences Vol 7 No 1 (2021)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v7i1.19645

Abstract

Aluminum is known has neurotoxin effect that can lead to alzheimer's disease, dementia, and parkinson's. Metal ions such as aluminum can distract homeostasis and increase oxidative stress level, formation of reactive oxygen species (ROS) that can overwhelm antioxidant defenses and cause DNA damage, lipid peroxidase, leading to the destruction of testicular cells. Tamarindus indica’s seeds are one of the traditional plant and useful as antioxidants. Tamarindus indica’s seeds are able to protect testicular cells from damage caused by ROS. The purpose of this study to determine the effect of methanol extract from Tamarindus indica’s seeds to prevent aluminum chloride induced testicular damage to be measured from the histopathological features. This study is a quasi experimental design with a posttest design only with non-equivalent groups using thirty male Wistar rats divided into five groups, one control group and four treatment groups. The control group was given 1 mL of aquabides solution orally. Group P1 was given a dose of aluminum solution 300 mg/kgBW orally. Groups P2, P3, and P4 were each given an aluminum solution at dose of 300 mg/kgBW orally and an extract solution at a dose of 25, 50, 100 mg/kgBW orally for 10 weeks. The results of the observations showed that the scores varied between groups. Data analysis using Kruskal-Wallis test obtained p value = 0.006 (p <0.05). Post Hoc test using Mann Whitney obtained varied p values. Post Hoc analysis between K and P1 groups, P1 and P3 groups, P1 and P4 groups showed a significant difference with p value <0.05. Based on the results of this study, methanol extract from tamarind seeds (Tamarindus indica) that was given to male wistar rats had prevented histopathological damage to the testes of rats induced by aluminum chloride (AlCl3). Keywords: aluminium, testicular cell, Tamarindus indica
Pembentukan Pos UKK Industri Pembuatan Brem di Desa Kalibaru Wilayah Kerja Puskesmas Mejayan Madiun Ayu Munawaroh Aziz
Warta Pengabdian Vol 13 No 3 (2019): Warta Pengabdian
Publisher : LP2M Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/wrtp.v13i3.8574

Abstract

Kegiatan pembentukan pos UKK dilakukan pada saat menempuh internship di Madiun. Kegiatan ini dilakukan sebagai bentuk dukungan dan aktualisasi dari peraturan menteri kesehatan mengenai pos kesehatan bagi pekerja sekto informal. Kegiatan di lakukan di desa kaliabu mejayan madiun karena merupakan salah satu sentra industri pembuatan brem dan sektor informal lainnya. Kegiatan dilakukan mulai dari tahap survei identifikasi masalah kesehatan kerja, penyuluhan, pengobatan dasar dan evaluasi hasil kegiatan. Berkat kerjasama lintas sektoral yang telah dilakukan , telah terbentuk Pos UKK percontohan untuk masyarakat pekerja di sektor informal desa Kaliabu . Program pembentukan Pos UKK ini cukup berhasil dilihat dari antusiasnya pekerja dalam mengikuti kegiatan Pos UKK dan berubahnya perilaku pekerja dalam keselamatan dan kesehatan kerja.
Hubungan kualitas tidur dengan tinggi badan pada remaja usia 10-15 tahun Septa surya wahyudi; Ayu munawaroh aziz; Alfina kamelia fakhriyah
Majalah Kedokteran Andalas Vol 44, No 2 (2021): Online July 2021
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v44.i2.p93-103.2021

Abstract

Kualitas tidur yang baik harus dicapai seseorang untuk mendapatkan manfaat dari tidur. Selama periode tidur, tubuh menyekresikan GH dalam darah. Sekresi GH mencapai puncaknya saat tidur nyenyak terutama tengah malam. Kadar GH yang disekresikan saat tidur dapat berpengaruh terhadap pertumbuhan fisik terutama tinggi badan pada masa pertumbuhan.Penelitian ini merupakan observasional analitik, menggunakan pendekatan cross sectional. Bertujuan untuk mengetahui hubungan kualitas tidur dengan tinggi badan pada remaja usia 10-15 tahun. Teknik pengambilan sampel menggunakan teknik proportional stratified random sampling dengan menggunakan kriteria inklusi dan eksklusi. Teknik pengambilan data dilakukan dengan cara wawancara, pemeriksaan tinggi badan berat badan. Analisis data dilakukan menggunakan uji Chi Square.Penelitian menunjukkan sampel yang mempunyai kualitas tidur baik yakni 26 sampel (86,7%), kualitas tidur buruk sebanyak 4 sampel (13,3%). Sebanyak 16 sampel (53,3%) mempunyai tinggi badan sesuai nilai normal menurut usia dalam pedoman WHO, Kemenkes RI, dan CDC pada tahun 2001, 14 sampel (46,7%) lainnya tidak sesuai pedoman tersebut. Hasil uji Chi Square menunjukkan hubungan yang signifikan antara kualitas tidur dengan tinggi badan (p=0,022). Hal ini menunjukkan bahwa terdapat hubungan antara kualitas tidur dengan tinggi badan pada remaja usia 10-15 tahun. Semakin baik kualitas tidur, maka tinggi badan anak akan semakin sesuai dengan nilai normal menurut usia.
Perbedaan Forced Vital Capacity (FVC) pada Wanita Menopause dan Wanita Usia Subur Pekerja Pabrik Tembakau Ayu Munawaroh Aziz; Ida Srisurani W. A.; Madha Qoyyulledy Tursina
Jurnal Kesehatan Vol 8 No 1 (2020): April
Publisher : Politeknik Negeri Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25047/j-kes.v8i1.145

Abstract

Pekerja pabrik tembakau dikelilingi oleh berbagai bahaya kesehatan kerja. Debu tembakau yang terhirup terus menerus menyebabkan akumulasi di saluran pernapasan yang menyebabkan peradangan dan menghasilkan jaringan fibrotik yang dapat mengurangi ekspansi paru-paru (restriction). Forced Vital Capacity (FVC) dalam hasil spirometri digunakan sebagai parameter untuk pola gangguan restriksi paru-paru. Penelitian ini bertujuan untuk mengetahui perbedaan FVC pada wanita menopause dan wanita pekerja pabrik tembakau usia subur. Jenis penelitian ini adalah observasional analitik dengan rancangan studi cross-sectional. Sampel penelitian ini adalah pekerja wanita menopause dan wanita usia subur yang bekerja di produksi pabrik tembakau. Pengumpulan data dilakukan wawancara dengan kuesioner, dan data FVC diperoleh dari hasil pemeriksaan spirometri. Penelitian ini menggunakan desain penelitian observasional analitik cross-sectional dan Unpaired T-test. Pengumpulan data tentang karakteristik individu dilakukan dengan kuesioner, sedangkan data FVC diperoleh dari spirometri. Hasil penelitian menunjukkan bahwa mayoritas pekerja pabrik tembakau perempuan mengalami penurunan nilai FVC dalam bentuk pembatasan paru-paru dan ada perbedaan nilai FVC yang signifikan antara wanita menopause dan wanita usia subur pada pekerja pabrik tembakau.
Screening for Non-Communicable Diseases and Cardiopulmonary Resucitation Education in Kranjingan Village, Sumbersari District, Jember Regency Lirista Dyah Ayu Oktafiani; Arina Mufida Ersanti; Ayu Munawaroh Aziz
ABDIMAYUDA: Indonesia Journal of Community Empowerment for Health Vol 1 No 2 (2022)
Publisher : Faculty of Public Health, University of Jember in collaboration with PERSAKMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (259.557 KB) | DOI: 10.19184/abdimayuda.v1i2.28536

Abstract

Non-communicable diseases (NCDs) are catastrophic diseases that can cause an increase in the socio-economic burden for sufferers, their families and the government, because their treatment takes a long time, costs a lot and requires high technology. Cardiovascular disease is one of the PTM diseases in Jember Regency which has a high prevalence of cases. Screening activities through posbindu are one of the efforts that can be done to prevent and control PTM. This activity aimed to screen NCDs and improve Cardiopulmonary Resuscitation (CPR) skills in the Kranjingan Village community, Sumbersari District, Jember Regency. This activity was carried out through several stages, starting with counseling, examining early detection of PTM risk factors, counseling and CPR training. Screening activities were important to be carried out to increase public awareness of non-communicable diseases through early detection, early treatment and controlling risk factors so as to reduce morbidity and mortality rates. After this activity, it was known that there has been an increase in participants' knowledge related to Cardiopulmonary Resuscitation (CPR) skills in the community in Kranjingan Village, Sumbersari District, Jember Regency.
Potential of B-Cell Epitopes Protein Ag85 Complex Mycobacterium Tuberculosis as Serodiagnostic Antigen of Tuberculosis by in Silico Study Diana Chusna Mufida; Ayu Munawaroh Aziz; Nurrul Izza Misturiansyah
Journal of Biomedicine and Translational Research Vol 9, No 1 (2023): April 2023
Publisher : Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jbtr.v9i1.16379

Abstract

Background: The high case of tuberculosis which isn't followed by good detection becomes an urgency for the diagnostic developments. One of them with immunodiagnostic principle uses B-cell Ag85 complex epitope. The design of the diagnostic epitope was performed by mapping the B cell epitope used in silico studies.Objective: The purpose of this research is to analyze antigenicity, physicochemical which affect immunogenicity, and homology of B-cell Ag85 complex epitope with the strain which circulates in Indonesia.  Methods: The samples used were taken from the NCBI protein bank with access numbers P9WQP3 for Ag85A, P9WQP1 for Ag85B, and P9WQN9 for Ag85C. The sequences were analyzed using IEDB (Bepipred) software as the epitope prediction, VaxiJen as antigenicity prediction, ProtParam as physicochemical properties prediction, and BLASTP NCBI as sequence alignment.Results: Twenty seven epitopes were antigenic with 0.4297 to 2.6007 scores and the molecular weight was from 619.59 Da to 3145.36 Da. This research also obtained eleven stable and hydrophilic epitopes. The alignment of 11 candidate epitopes with the strain which circulates in Indonesia, had a similarity percentage of 85.71%-100% and 3 epitopes had a more significant score.Conclusion: Three epitopes of Ag85 complex; Ag85A (212-235), Ag85B (209-237), and Ag85C (283-310), were universal antigens and can be developed into diagnostic antigens in Indonesia. 
Correlation of Soil Contamination and Incident of STH Infection in Sukokerto Village Sukowono District Jember Regency Bagus Hermansyah; Yunita Armiyanti; Wiwien Sugih Utami; Aulya Rahmi; Ayu Munawaroh Aziz
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 8 No 02 (2024): Qanun Medika Vol 08 No 02 2024
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v8i02.18731

Abstract

The most common worm infections are those caused by soil-transmitted helminths (STH) infection. Soil contamination is one of the causes of helminth transmission to humans. Poor environmental sanitation and personal hygiene facilitate the spread and transmission of STH. Jember is a district where the majority of the population lives in rural areas with poor sanitation access. This study aims to determine the correlation between soil contamination and incident of STH infection in Sukokerto Village, Sukowono District, Jember Regency. This cross-sectional analytic observational study was conducted from August 2022 to February 2023. The total of samples in this study was 44 fecal and soil around the house. The data obtained from the laboratory examination showed that the total fecal positive of STH was 11 or 25%, and soil was 13 or 29.5%. The results of the Chi-Square test analysis obtained ρ<0.05 (ρ=0.036, OR=4,457). The results showed a significant relationship between soil contamination and the incidence of STH infection in Sukokerto Village, Sukowo District, Jember Regency
Antioxidant Effect of Shallot Peel Infusion on Kidney Oxidative Stress in Diazinon-Induced Wistar Rats Helianti, Dina; Rosita Dewi; Ayu Munawaroh Aziz; Sheila Rachmania
Jurnal Kesehatan dr. Soebandi Vol 11 No 2 (2023): Jurnal Kesehatan dr. Soebandi
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat Universitas dr. Soebandi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36858/jkds.v11i2.394

Abstract

Diazinon is a pesticide widely used by farmers to control pests. Exposure to the low doses of diazinon can occur continuously through a polluted environment and diazinon residues in agricultural products. It has a nephrotoxic effect through oxidative stress mechanism. Flavonoid as antioxidant can significantly neutralize oxidative stress. Shallot peel is a source of flavonoids. This study was designed to determine the antioxidant effect of shallot skin infusion (SPI) on kidney oxidative stress in diazinon-induced Wistar rats by measuring the flavonoid level of SPI and kidney malondialdehyde (MDA) level. Rats were divided into normal, diazinon, and SPI groups. Diazinon was administered at dose of 40 mg/kgBW for 7 days followed by SPI at doses of 500, 1,000, and 2,000 mg/kgBW for 7 days. The flavonoid level of SPI was measured using spectrophotometry method and the kidney MDA level was measured using ELISA method. The flavonoid level of SPI was 96.8 mg QE/L. The results showed that the normal group had the lowest kidney MDA level of 2.585 mM/mL, the diazinon group had the highest level of 2.708 M/mL, while the SPI group at dose of of 500, 1,000, and 2,000 mg/kgBW had renal MDA levels of 2.642 mM/mL, 2.644 mM/mL, and 2.593 mM/mL. Nevertheless, the result of statistical analysis showed that the kidney MDA levels seven days after diazinon administration was not significantly different from the normal group so that SPI administration did not affect the kidney MDA level in diazinon-induced Wistar rats. Keyword: Shallot Peel, Diazinon, Oxidative Stress, Kidney Malondialdehyde
Co-Authors Aditya Kurniawan Aditya Kurniawan Alfina kamelia fakhriyah Alifiah Zalika Azharra Arif Dwi WIcaksono Arina Mufida Ersanti Aulya Rahmi Aynani Tajriyan Bagus Hermansyah Desie Dwi Wisudanti Dhiemas Trisyuananda Eniestama Diana Chusna Mufida Dina Helianti Elang Avinindra Virgiananta Al-Hasany Gangsar Lintas Damai Ida Srisurani Wiji Astuti Ida Srisurani Wiji Astuti Ilham Fahmi Hadziqi Joshua Revival Suhendro Madha Qoyyulledy Tursina Madha Qoyyulledy Tursina Muhammad Iqbal Allun Wicaksono Muhammad Iqbal Fauzi Muhammad Naufal Maulana Nizar Arkana Abiyu Nugraha Wahyu Cahyana Nugraha Wahyu Cahyana Nurrul Izza Misturiansyah Oktafiani, Lirista Dyah Ayu Pilar Menara Falah Pradipta Pawitradyaka Wardhono Ralief Yusrial Fabiyyanza Rena Normasari Rio Dermawan Rista Setiani Rosita Dewi Rumman Karimah septa surya wahyudi, septa surya Sheila Rachmania Sheilla Rachmania, Sheilla Singgih Bektiarso Sudarti Sudarti Sudarti Sudarti Sumardi Sumardi Suryono Suryono Suryono Suryono Tania Ardiani Tegar Syaiful Qodar Ulfa Elfiah Wahyu Muldayani Wiwien Sugih Utami Yudha Nurdian Yunita Armiyanti Zaenab, Zahrina Isnandia Zahrina Isnandia Zaenab