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All Journal Bioscientia Medicina : Journal of Biomedicine and Translational Research Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Bioscientia Medicina : Journal of Biomedicine and Translational Research
Nurmalia Purnama Sari
Department Of Clinical Pathology, Faculty Of Medicine, Universitas Sriwijaya, Palembang, Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience

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Characteristic of Bacterias And Antibiotic Sensitivity of Blood Culture in Sepsis Jesica Sidabutar; Nurmalia Purnama Sari; Phey Liana
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 1 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i1.163

Abstract

Introduction: Sepsis is a group of symptoms caused by infection, characterized by organ dysfunction due to compromised hosts response to infection hence may lead to a life-threatening condition. One of the treatments for sepsis stated in one hour-bundle is the administration of broad-spectrum antibiotics before the culture results obtained. Improper use of antibiotics may lead to antibiotic resistance. The purpose of this study was to describe the microbes pattern and their sensitivity to antibiotics in patients with sepsis at Muhammad Hoesin Hospital, Palembang, to contribute to a useful treatment guideline and to provide a reference for further research. Methods: This study was a descriptive observational study with a cross-sectional design using medical record of patients diagnosed with sepsis whose blood culture results were positive. This study was conducted at Muhammad Hoesin Hospital, Palembang, from January 2017 to December 2018. The data was processed and analyzed by univariate analysis using the SPSS 21.0 computer program. Results: The study subjects were predominantly children with Gram-positive bacteria (24.6%) as the most common cause. The most common bacteria observed were Staphylococcus epidermidis (35.7%), Staphylococcus aureus (27.3%), Staphylococcus haemolyticus (24%), and Staphylococcus hominis (21.4%). Linezolid (100%), nitrofurantoin (100%), and quinupristin/dalfopristin (100%) were found to be sensitive to gram-positive bacteria. Conclusion: Gram-positive bacteria were the most common cause of sepsis in Muhammad Hoesin Hospital, Palembang. The bacteria were sensitive to linezolid, nitrofurantoin, and quinupristin/ dalfopristin.
The Diagnostic Value of Neutrophil-Lymphocyte Ratio in Diagnosis of Autism Spectrum Disorders Nurmalia Purnama Sari; Yudianita K; M. Rafli Haiqal; M. Fadill Akbar
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 26, No 3 (2020)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v26i3.1597

Abstract

Autism Spectrum Disorder (ASD) is a complex neurodevelopmental disorder, progressive disruption of brain development and synaptic connections, which causes impaired communication and behavioral disorders. However, the etiology is unknown. A damaged perinatal environment causes chronic nerve inflammation in genetically susceptible children of ASD, dysregulation of the immune system, which leads to ASD. The ratio of Neutrophil to Lymphocyte (NLR) as one of the markers of inflammation is frequently associated with inflammation-related psychiatric diseases and is potentially used as a diagnostic instrument. A cross-sectional study was carried out from June to November 2019 by using medical records of Outpatients with growth and development disorders and ASD and involving 69 children. The diagnosis of ASD was confirmed by the fifth edition Diagnostic and Manual of Mental Disorders criteria (DSM-V). A routine hematology test was carried out with a flow cytometry method. Diagnostic tests were performed in 43 children with developmental disorders (mean NLR 1.01±0.07) and 26 ASD children (mean NLR 1.02±0.06), with a cut-off value of 0.68. Sensitivity, specificity, positive predictive value, negative predictive value and accuracy of NLR were 84.62%; 27.9%; 41.51%; 25%; and 50.2%, respectively. Neutrophil to lymphocyte is sensitive to diagnose ASD but its accuracy is low. Immune dysfunction and complex neurodevelopmental disorders that are affected by chronic inflammation play a role in the occurrence of ASD. Other inflammatory markers are needed to improve the accuracy of laboratory tests to diagnose ASD.
Characteristic of Bacterias And Antibiotic Sensitivity of Blood Culture in Sepsis Jesica Sidabutar; Nurmalia Purnama Sari; Phey Liana
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 1 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i1.163

Abstract

Introduction: Sepsis is a group of symptoms caused by infection, characterized by organ dysfunction due to compromised hosts response to infection hence may lead to a life-threatening condition. One of the treatments for sepsis stated in one hour-bundle is the administration of broad-spectrum antibiotics before the culture results obtained. Improper use of antibiotics may lead to antibiotic resistance. The purpose of this study was to describe the microbes pattern and their sensitivity to antibiotics in patients with sepsis at Muhammad Hoesin Hospital, Palembang, to contribute to a useful treatment guideline and to provide a reference for further research. Methods: This study was a descriptive observational study with a cross-sectional design using medical record of patients diagnosed with sepsis whose blood culture results were positive. This study was conducted at Muhammad Hoesin Hospital, Palembang, from January 2017 to December 2018. The data was processed and analyzed by univariate analysis using the SPSS 21.0 computer program. Results: The study subjects were predominantly children with Gram-positive bacteria (24.6%) as the most common cause. The most common bacteria observed were Staphylococcus epidermidis (35.7%), Staphylococcus aureus (27.3%), Staphylococcus haemolyticus (24%), and Staphylococcus hominis (21.4%). Linezolid (100%), nitrofurantoin (100%), and quinupristin/dalfopristin (100%) were found to be sensitive to gram-positive bacteria. Conclusion: Gram-positive bacteria were the most common cause of sepsis in Muhammad Hoesin Hospital, Palembang. The bacteria were sensitive to linezolid, nitrofurantoin, and quinupristin/ dalfopristin.
The Diagnostic Value of Neutrophil-Lymphocyte Ratio in Diagnosis of Autism Spectrum Disorders Nurmalia Purnama Sari; Yudianita K; M. Rafli Haiqal; M. Fadill Akbar
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 26 No. 3 (2020)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v26i3.1597

Abstract

Autism Spectrum Disorder (ASD) is a complex neurodevelopmental disorder, progressive disruption of brain development and synaptic connections, which causes impaired communication and behavioral disorders. However, the etiology is unknown. A damaged perinatal environment causes chronic nerve inflammation in genetically susceptible children of ASD, dysregulation of the immune system, which leads to ASD. The ratio of Neutrophil to Lymphocyte (NLR) as one of the markers of inflammation is frequently associated with inflammation-related psychiatric diseases and is potentially used as a diagnostic instrument. A cross-sectional study was carried out from June to November 2019 by using medical records of Outpatients with growth and development disorders and ASD and involving 69 children. The diagnosis of ASD was confirmed by the fifth edition Diagnostic and Manual of Mental Disorders criteria (DSM-V). A routine hematology test was carried out with a flow cytometry method. Diagnostic tests were performed in 43 children with developmental disorders (mean NLR 1.01±0.07) and 26 ASD children (mean NLR 1.02±0.06), with a cut-off value of 0.68. Sensitivity, specificity, positive predictive value, negative predictive value and accuracy of NLR were 84.62%; 27.9%; 41.51%; 25%; and 50.2%, respectively. Neutrophil to lymphocyte is sensitive to diagnose ASD but its accuracy is low. Immune dysfunction and complex neurodevelopmental disorders that are affected by chronic inflammation play a role in the occurrence of ASD. Other inflammatory markers are needed to improve the accuracy of laboratory tests to diagnose ASD.
Co-Authors Jesica Sidabutar M. Fadill Akbar M. Rafli Haiqal Phey Liana Yudianita Kesuma, Yudianita