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Abnormal Uterine Bleeding in Adolescent Kms Yusuf Effendi; Rizani Amran; Iskandar Zulqarnain; Heriyadi Manan; Adnan Abadi; Fatimah Usman; Awan Nurtjahyo; Cindy Kesty; Siti Chodijah; Selly Rizany
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 1 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v6i1.431

Abnormal uterine bleeding (AUB) is defined as the abnormal bleeding from the uterine corpus in term of duration, volume, frequency and/or regularity. This condition occurs in 37% of adolescents and may affect the quality of life and increased hospitalization. Etiology is divided into structural and non-structural causes, known as PALM-COEIN. The most common etiology in adolescents is anovulatory menstruation due to immature hypothalamus-hypophysis axis. Diagnostic evaluation should include investigation in the etiology of AUB, anemia signs, and hemodynamic status. Treatment of AUB consists of hormonal and non-hormonal therapy. Therapy in adolescent is given based on the severity of bleeding, grading of anemia, and hemodynamic stability. Follow-up is required after therapy. Understanding AUB in adolescents can help clinicians deliver appropriate and comprehensive treatment. This review was aimed to explain about definition, epidemiology, etiology, pathophysiology, diagnosis, and treatment of abnormal uterine bleeding in adolescent.

Cortisol Level Related to Depression in Women with Endometriosis Adnan Abadi; Aria Indrabrata; Iskandar Zulqarnain; Theodorus; Abdullah Sahab; Kemas Yusuf Effendi; Heriyadi Manan; Fatimah Usman; Awan Nurtjahyo; Cindy Kesty
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 6 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i6.537

Background: Several main symptoms of endometriosis can lead to physical and psychological stress and also hormonal disturbances as the result of prolonged stress. Cortisol was associated with the onset of depression. This study aimed to determine the relationship between cortisol levels and depression in women with endometriosis at the Department of Obstetrics and Gynecology at Dr. Mohammad Hoesin General Hospital (RSMH) Palembang. Methods: A cross-sectional study was performed at the Reproductive Endocrinology and Infertility outpatient clinic and inpatient ward, Department of Obstetrics and Gynecology at Dr. Mohammad Hoesin General Hospital Palembang, from January to November 2020. There were 74 samples of endometriosis patients who met the inclusion criteria. The blood cortisol level was examined using the ELISA method. The determination of depression level was performed by filling out the Beck Depression Inventory questionnaire. Data were analyzed using SPSS version 22.0. Results: Seventy-four samples met the inclusion criteria. As many as 44 patients (59.5%) without depression, 20 patients (27%) with mild depression, 8 patients (10.8%) with moderate depression, and only 2 patients (2.7%) with severe depression. There were no differences in age, marital status, parity, menstrual cycle, and duration of treatment between endometriosis patients with and without depression (p > 0.05). There was a significant difference in cortisol levels between endometriosis patients with and without depression (p = 0.017). Endometriosis patients with cortisol levels ≤ 7.4 mg/dl were three times more at risk of depression than endometriosis patients with cortisol levels > 7.4 mg/dl. In addition, there was a significant relationship between cortisol level and depression status (OR = 3.023 (95% CI 1.153–7.942; p = 0.041). This study also found a significantly low negative correlation between cortisol levels and BDI scores (r = -0.249; p = 0.032). Conclusion: There was a significant relationship between serum cortisol levels and depression in women with endometriosis. Endometriosis patients with depression had significantly lower cortisol levels than endometriosis patients without depression.

The Role of Low Dosage Combined Oral Contraceptive Pill in Perimenopausal Women A. Abadi; Fatimah Usman; Awan Nurtjahyo; Cindy Kesty
Jurnal RSMH Palembang Vol. 2 No. 1 (2021): Jurnal RSMH Palembang
Publisher : RSUP Dr Moh Hoesin Palembang

The perimenopausal period refers to the time period of the menstrual cycle and endocrine changes. Usually, it starts with a variation in the menstrual cycle length and ending with FMP. The rates of unwanted pregnancies for these women are reported to be around 40–45%. Thus, contraceptive counselling and contraceptive use among perimenopausal women are important aspects of their overall health care if they are sexually active and do not wish to become pregnant. One of them is by using low dose combined oral contraceptive pill containing ethynylestradiol (EE) containing less than 50 µg EE/day. It acts by supressing gonadotropin. There are several positive effects of COC, namely pregnancy prevention; regulation of menstrual cycle; relieving menopausal symptoms; bone protection; protection against ovarian, endometrial and colorectal cancer; lipid metabolism; and blood pressure lowering effect. In contrast, the negative effects of COC are increases the risk of breast cancer, venous thromboembolism, and myocardial infarction. We presented a literature review to describe the usage of low dosage combined oral contraceptive pill as one of contraception method in perimenopausal women, including its positive and negative effects.

Abnormal Uterine Bleeding in Adolescent Kms Yusuf Effendi; Rizani Amran; Iskandar Zulqarnain; Heriyadi Manan; Adnan Abadi; Fatimah Usman; Awan Nurtjahyo; Cindy Kesty; Siti Chodijah; Selly Rizany
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 1 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v6i1.431

Abnormal uterine bleeding (AUB) is defined as the abnormal bleeding from the uterine corpus in term of duration, volume, frequency and/or regularity. This condition occurs in 37% of adolescents and may affect the quality of life and increased hospitalization. Etiology is divided into structural and non-structural causes, known as PALM-COEIN. The most common etiology in adolescents is anovulatory menstruation due to immature hypothalamus-hypophysis axis. Diagnostic evaluation should include investigation in the etiology of AUB, anemia signs, and hemodynamic status. Treatment of AUB consists of hormonal and non-hormonal therapy. Therapy in adolescent is given based on the severity of bleeding, grading of anemia, and hemodynamic stability. Follow-up is required after therapy. Understanding AUB in adolescents can help clinicians deliver appropriate and comprehensive treatment. This review was aimed to explain about definition, epidemiology, etiology, pathophysiology, diagnosis, and treatment of abnormal uterine bleeding in adolescent.

Cortisol Level Related to Depression in Women with Endometriosis Adnan Abadi; Aria Indrabrata; Iskandar Zulqarnain; Theodorus; Abdullah Sahab; Kemas Yusuf Effendi; Heriyadi Manan; Fatimah Usman; Awan Nurtjahyo; Cindy Kesty
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 6 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i6.537

Background: Several main symptoms of endometriosis can lead to physical and psychological stress and also hormonal disturbances as the result of prolonged stress. Cortisol was associated with the onset of depression. This study aimed to determine the relationship between cortisol levels and depression in women with endometriosis at the Department of Obstetrics and Gynecology at Dr. Mohammad Hoesin General Hospital (RSMH) Palembang. Methods: A cross-sectional study was performed at the Reproductive Endocrinology and Infertility outpatient clinic and inpatient ward, Department of Obstetrics and Gynecology at Dr. Mohammad Hoesin General Hospital Palembang, from January to November 2020. There were 74 samples of endometriosis patients who met the inclusion criteria. The blood cortisol level was examined using the ELISA method. The determination of depression level was performed by filling out the Beck Depression Inventory questionnaire. Data were analyzed using SPSS version 22.0. Results: Seventy-four samples met the inclusion criteria. As many as 44 patients (59.5%) without depression, 20 patients (27%) with mild depression, 8 patients (10.8%) with moderate depression, and only 2 patients (2.7%) with severe depression. There were no differences in age, marital status, parity, menstrual cycle, and duration of treatment between endometriosis patients with and without depression (p > 0.05). There was a significant difference in cortisol levels between endometriosis patients with and without depression (p = 0.017). Endometriosis patients with cortisol levels ≤ 7.4 mg/dl were three times more at risk of depression than endometriosis patients with cortisol levels > 7.4 mg/dl. In addition, there was a significant relationship between cortisol level and depression status (OR = 3.023 (95% CI 1.153–7.942; p = 0.041). This study also found a significantly low negative correlation between cortisol levels and BDI scores (r = -0.249; p = 0.032). Conclusion: There was a significant relationship between serum cortisol levels and depression in women with endometriosis. Endometriosis patients with depression had significantly lower cortisol levels than endometriosis patients without depression.

Tatalaksana Praktis Gangguan Haid di Praktek Sehari-hari Fatimah Usman
Conferences of Medical Sciences Dies Natalis Vol. 1 No. 1 (2019): Conferences of Medical Sciences Dies Natalis Faculty of Medicine Universitas Sr
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (739.724 KB)

Menstrual disorders are the most common disorders in women of childbearing age and the most common complaint in gynecological outpatient practices in several hospitals. Besides disrupting activities, menstrual disorders can be a serious problem as a life threatening condition. Menstrual disorders can be divided based on the duration and the etiology. Based on the duration of occurrence, acute and chronic can be distinguished. Etiology can be distinguished based on abnormal uterine bleeding criteria (PALM-COEIN). The management of this kind of disorder depends on the type of cause of abnormal uterine bleeding. Surgical and non-surgical management can be used as an option in the treatment of menstrual disorders. Hormonal therapy options are the most popular treatment options at present with minimal side effects and relatively affordable prices. Management of abnormal uterine bleeding aims to improve the general condition, stop bleeding, and restore the function of reproductive hormones. Stopping bleeding can be done with medical, dilatation and curettage, as well as operative measures.

INFERTILITY SCREENING Rizani Amran; Kms Yusuf Effendi; Iskandar Zulqarnain; Heriyadi Manan; Fatimah Usman; M Komarul Hakim; Vicela Patricia; Selly Rizany; Anton Rama; Achmad Fachroni
Conferences of Medical Sciences Dies Natalis Vol. 3 No. 1 (2021): Conference of Medical Sciences Dies Natalis Faculty of Medicine Universitas Sri
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (297.803 KB)

Infertility is a common condition caused by the female factor, male factor, or both. Infertility problems can have a significant impact on married couples who experience them. In addition to causing medical problems, infertility can also cause economic and psychological problems. Couples who experience infertility will undergo a long process of evaluation and treatment, where this process can be both physical and psychological for the infertile couple. The aim of this article is presenting a literature study on infertility screening. Infertility affects millions of people of reproductive age worldwide and impacts family and community life. Estimates suggest that between 48 million couples and 186 million people are living with infertility. Infertility occurs in 15% of couples. Female factors cause infertility in 50-70%, and malefactors are the cause of infertility in 40-50% of couples. Given the high prevalence of malefactors in infertility heterosexual couples, medical history and early evaluation of male partners are needed. Ovulation dysfunction was defined as a history of oligomenorrhea or amenorrhea, recurrent luteal progesterone levels of less than 3 ng/mL, or both. For many women, a menstrual history is sufficient to assess ovulatory function. The clinical history can be used to assess the ovulatory cycle as most women will have regular menstrual cycles every 25–35 days. Anovulation may be associated with obesity, hypothalamic and pituitary dysfunction, PCOS, and other etiologies. Polycystic ovary syndrome is the most common cause of ovulatory infertility. Women with PCOS who have been diagnosed are at increased risk of the metabolic syndrome associated with cardiovascular events and negatively impacting pregnancy. Infertility is the failure of a couple to get pregnant for at least 12 months having regular sex without contraception, or also known as primary infertility. Secondary infertility is the inability of a person to have children or maintain a pregnancy. Idiopathic infertility refers to infertile couples who have undergone standard examinations, including ovulation tests, tubal patency, and semen analysis with normal results.

Hubungan Pola Makan dengan Risiko Terjadinya Sindrom Ovarium Polikistik pada Remaja Angela Irene; Syifa Alkaf; Eka Febri Zullisetiana; Fatimah Usman; Veny Larasaty
Sriwijaya Journal of Medicine Vol. 3 No. 1 (2020): Vol 3, No 1, 2020
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v3i1.66

Sindrom Ovarium Polikistik (SOPK) merupakan gangguan endokrin yang paling umum terjadi pada wanita dengan konsekuensi luas yang memengaruhi setiap aspek kehidupan wanita, dengan angka kejadian SOPK pada remaja kurang lebih 11-26%. Lebih dari 50% pasien SOPK dikaitkan dengan sindrom metabolik termasuk obesitas, resistensi insulin, dan dislipidemia. Penelitian-penelitian terdahulu mengatakan bahwa pola makan memerankan peranan penting sebagai faktor risiko terjadinya SOPK pada remaja. Maka dari itu pengaturan pola makan sangat penting untuk memperbaiki gangguan hormonal dan efek jangka panjang akibat SOPK, sehingga perlu dilakukan analisis lebih lanjut mengenai hubungan pola makan dengan risiko terjadinya SOPK pada remaja yang berusia 15-19 tahun di Kota Palembang. Penelitian ini merupakan penelitian observasional dengan desain potong-lintang. Data yang diambil merupakan data primer pada remaja berusia 15-19 tahun di Kota Palembang. Pengambilan data pola makan pada responden dilakukan dengan kuesioner food recall. Perhitungan kalori dan makronutrien menggunakan software nutrisurvey. Diagnosis SOPK ditegakkan dengan temuan dua dari tiga kriteria Rotterdam. Dari total 150 sampel, sebagian besar dengan siklus menstruasi normal, IMT yang overweight/obese, intake kalori, konsumsi karbohidrat, dan lemak yang berlebih, konsumsi protein yang cukup, serta konsumsi serat yang kurang. Terdapat sebanyak 38 sampel (25,3%) dengan kejadian SOPK. Sampel yang mengalami SOPK, sebagian besar dengan IMT yang overweight/obese (p<0,05), intake kalori, konsumsi karbohidrat, protein, lemak yang berlebih (p<0,05), serta konsumsi serat yang kurang (p>0,05). Terdapat hubungan yang bermakna antara intake kalori, konsumsi karbohidrat, protein, dan lemak yang berlebih, serta konsumsi serat yang kurang dan risiko terjadinya Sindrom Ovarium Polikistik (SOPK) pada remaja yang berusia 15-19 tahun di Kota Palembang.

The Relationship between Menstrual Patterns and Pain Scale in Endometriosis Patients at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia Fatimah Usman; Megan Reginia Rusli; Eka Handayani Oktharina; Kemas Yusuf Effendi; Syifa Alkaf
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 17 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i17.714

Background: Endometriosis is a disease characterized by the presence of tissue resembling the endometrium (uterine lining) outside the uterus. This causes a chronic inflammatory reaction that can result in the formation of scar tissue in the pelvis and other parts of the body. Pain is the most common clinical complaint in cases of endometriosis. Pain during menstruation is often confused with pain due to endometriosis, so treatment delays often occur. This study aimed to determine the relationship between menstrual patterns and pain in endometriosis patients at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia. Methods: This was cross-sectional analytic observational study. A total of 55 research subjects participated in this study. Data analysis was carried out with the help of SPSS version 25 software in univariate and bivariate. Results: Menstrual cycle, duration, color, and volume of menstrual blood are not related to pain intensity in endometriosis patients. Conclusion: There is no relationship between menstrual patterns and pain in endometriosis patients at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia.

The Relationship between Menstrual Patterns and Pain Scale in Endometriosis Patients at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia Fatimah Usman; Megan Reginia Rusli; Eka Handayani Oktharina; Kemas Yusuf Effendi; Syifa Alkaf
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 17 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i17.714

Background: Endometriosis is a disease characterized by the presence of tissue resembling the endometrium (uterine lining) outside the uterus. This causes a chronic inflammatory reaction that can result in the formation of scar tissue in the pelvis and other parts of the body. Pain is the most common clinical complaint in cases of endometriosis. Pain during menstruation is often confused with pain due to endometriosis, so treatment delays often occur. This study aimed to determine the relationship between menstrual patterns and pain in endometriosis patients at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia. Methods: This was cross-sectional analytic observational study. A total of 55 research subjects participated in this study. Data analysis was carried out with the help of SPSS version 25 software in univariate and bivariate. Results: Menstrual cycle, duration, color, and volume of menstrual blood are not related to pain intensity in endometriosis patients. Conclusion: There is no relationship between menstrual patterns and pain in endometriosis patients at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia.

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