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All Journal BAREKENG: Jurnal Ilmu Matematika dan Terapan Indonesian Journal of Cardiology
Oktavia Lilyasari
Departemen Kardiologi Dan Kedokteran Vaskular FKUI/Pusat Jantung Nasional Harapan Kita
Computer Science & IT Control & Systems Engineering Economics, Econometrics & Finance Energy Engineering Health Professions Mathematics Mechanical Engineering Medicine & Pharmacology Physics Transportation

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Hipertensi Dengan Obesitas: Adakah Peran Endotelin-1? Oktavia Lilyasari
Jurnal Kardiologi Indonesia Vol. 28, No. 6 November 2007
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.v28i6.214

Abstract

Hipertensi merupakan penyebab utama tingginya morbiditas dan mortalitas kardiovaskular. Estimasi prevalensi hipertensi di seluruh dunia hampir 1 milyar orang, dan sekitar 7,1 juta kematian pertahun disebabkan oleh hipertensi. Hipertensi juga merupakan masalah kesehatan yang utama dan sering dijumpai di Indonesia. Prevalensi hipertensi di Indonesia masih tinggi. Studi berkesinambungan dari Monitoring Trends and Determinants of Cardiovascular Disease (MONICA) Jakarta melaporkan adanya peningkatan prevalensi hipertensi pada populasi Indonesia dari 16,9% (tahun 1993) menjadi 17,9% (tahun 2000). Sebagian besar subyek dengan tekanan darah (TD) tinggi adalah overweight,dan hipertensi lebih sering terjadi pada obesitas.Prevalensi hipertensi yang disertai dengan obesitas semakin meningkat. Hal ini tidak saja terjadi di negara maju, tetapi juga menjadi masalah di negara berkembang. Hal ini berkaitan erat dengan arus globalisasi dan perubahan pola hidup, yang menyebabkan peningkatan prevalensi overweight ataupun obesitas.Perubahan pola hidup yang negatif berdampak negatifterhadap respon tubuh. Hal ini menyebabkan perubahan metabolik dan kejadian adipositopati.
Korelasi Kadar Leptin Plasma Dengan Massa Ventrikel Kiri Pada Laki-Laki Normotensi Richard Indra Gunawan; Adrianus Kosasih; Oktavia Lilyasari; Andang H Joesoef; RWM Kaligis
Jurnal Kardiologi Indonesia Vol. 28, No. 5 September 2007
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.v28i5.220

Abstract

Background.Obesity is one of Cardiovascular risk factor. Obesity caused increase in heart mass due to cellular hypertrophic and metaplastic proses, independently of hemodynamic factors such as blood pressure. There were hyperleptinemia in obesity due to the selective Leptin resistency in central nervous system and peripheral organs. Study with cultured rat cardiomyocyte have shown hypertrophy and hyperplastic effect of Leptin to cardiomyocyte. Some clinical studies have shown correlation between circulating Leptin level with Left Ventricle Mass in hypertensive and insulin resistance men.Objective. This study aimed to elaborate the correlation between circu-lating Leptin level with Left Ventricle Mass in normotensive men.Methods. A cross sectional study was performed with normotensive men, which included 40 obese normotensive and 40 normoweight men. All patients underwent physical and laboratory assessment and examination of Left Ventricle with echocardiography. The circulating Leptin level were determined by ELISA method. The Leptin level were expressed as median (25th percentile; 75th percentile)Results. The circulating Leptin level were significantly different between the obese normotensive and the lean group. The Left Ventricle Mass in Obese increased, although have not fulfilled the criteria for Left Ventricle Hypertrophy. There were significant correlation between Left Ventricle Mass with BMI (r = 0,711; p<0,001) and waist circumference (r = 0,732; p<0,001). Respectively, there were significant correlation between Left Ventricle Mass Index with BMI (r = 0.541; p<0.001) and waist circumfer-ence (r = 0,558; p<0.001. There were significant correlation between circulating Leptin level with Left Ventricle Mass (r = 0,510; <0,001) and Left Ventricle Mass Index (r = 0,414; p<0,001) in obese men.Conclusion.Circulating Leptin level is correlated with Left Ventricle Mass in normotensive men.
Korelasi Kekakuan Arteri Dengan Kadar Endothelin-1 Plasma pada Laki-laki Obesitas Adrianus Kosasih; Oktavia Lilyasari; Richard Indra Gunawan; Nur Haryono; Ismoyo Sunu
Jurnal Kardiologi Indonesia Vol. 28, No. 4 Juli 2007
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.v28i4.227

Abstract

Background.Obesity is associated with increase arterial stiffness and el-evated plasma endothelin-1 concentration. However, there is still conflict-ing data regarding the effect of obesity on arterial stiffness and plasma endothelin-1 concentration.Objective.The purpose of the current study was to assess this effect and analyze whether there was correlation between arterial stiffness indices and plasma endothelin-1 concentration.Methods.The design of the study was cross sectional study that compare and correlate arterial stiffness and plasma endothelin-1 concentration be-tween obesity group (n=40) and normoweight group (n=40). Obesity was defined as body mass index = 25 kg/m2. Arterial stiffness was as-sessed by measuring carotid-femoral pulse wave velocity (PWV) dan ß stiffness index (ß) non-invasively using ultrasound method. Endothelin-1 was measured by ELISA.Results.There was no significant difference regarding PWV between obesity and normoweight group (mean ± SD: 809.44 ± 137.77 versus 850.96 ± 211.60 cm/s, p=NS), but ßwas significantly higher in obese group (8.79 ± 3.15 versus 7.28 ± 1.96, p=0.012). PWV and ßcorre-lated significantly with age (PWV: r=0.446, p<0.001, ß: r=0.354, p=0.001), but only ßcorrelated with body mass index (r=0.282, p=0.011) and waist circumference (r=0.312, p=0.005). There was no significant difference between obesity and normoweight group regard-ing plasma endothelin-1 concentration (0.94 ± 0.26 versus 0.95 ± 0.18 pg/dl, p=NS). There are no significant correlations between PWV/ßand plasma endothelin-1 concentration.Conclusions.These findings suggest that the effect of obesity on arterial stiffness is not uniformly seen throughout all arterial region. Obesity im-pact on carotid artery is greater than its impact on aorta, and this impact on arterial stiffness is not mediated by endothelin-1.
Pencitraan Resonansi Magnetik Kardiovaskular pada Penyakit Jantung Bawaan Oktavia Lilyasari
Jurnal Kardiologi Indonesia Vol. 34, No. 1 Januari - Maret 2013
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.v34i1.297

Abstract

Pencitraan merupakan suatu hal yang fundamental dalam diagnosis Penyakit Jantung Bawaan (PJB). Pencitraan Resonansi Magnetis Kardiovaskular (Cardiovascular Magnetic Resonance/CMR) menjadi teknik penting dalam diagnosis dan tatalaksana penyakit kardiovaskular. Data contagious 3D yang merupakan kekuatan CMR sangat efektif memberikan gambaran lengkap patologi anatomi PJB sederhana ataupun kompleks. CMR dapat menyajikan gambar tiga dimensi dengan resolusi tinggi dan memungkinkan untuk rekonstruksi visualisasi kelainan jantung yang kompleks.Saat ini pencitraan dengan menggunakan CMR menjadi tekhnik penting dan adekuat dalam menilai fungsi ventrikel, aliran dinamis intra kardiak, termasuk regurgitasi dan stenosis katup, aliran pembuluh darah besar, karakterisasi anatomi kelainan bawaan yang kompleks, terutama yang berhubungan dengan vena sistemik dan pulmonal, hubungan antar ruang jantung (atrioventricular connection, ventriculo-arterial connection). CMR juga dapat mengurangi jumlah prosedur kateterisasi diagnostik untuk evaluasi pre dan post tindakan intervensi bedah maupun non bedah, sehingga dapat meminimalisasi efek radiasi yang ditimbulkan oleh prosedur kateterisasi.Beberapa kesulitan timbul saat melakukan pemeriksaan CMR pada anak yang kecil. Diperlukan beberapa penyesuaian untuk menghasilkan kualitas gambar yang optimal, karena ukuran struktur jantung yang lebih kecil, frekuensi nadi yang lebih cepat, kesulitan atau ketidakmampuan untuk mengikuti komando tahan nafas dan kurangnya kerjasama pasien.Penggunaan klinis CMR tergantung dari usia dan kondisi klinis pasien. Pencitraan Resonansi Magnetik Kardiovaskular menjadi teknik utama terutama pada anak-anak yang cukup besar, remaja atau dewasa pada kelainan anatomi yang kompleks, dan evaluasi post operasi.
Giant Coronary Artery Aneurysms in Kawasaki Disease Detected by Multi Detector Computed Tomographic Oktavia Lilyasari; Poppy S Roebiono; Radityo Prakoso; Anna Ulfah Rahajoe; Indriwanto Sakidjan; Ganesja M Harimurti
Jurnal Kardiologi Indonesia Vol. 34, No. 2 April - Juni 2013
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.v34i2.331

Abstract

Kawasaki disease is an acute, self -limited vasculitis of unknown etiology that occurs predominantly in infants and young children. The major sequele of Kawasaki disease are related to the coronary arterial system. Cardiac imaging is a critical part in evaluation of all patients with suspected Kawasaki disease. Multi Detector CT (MDCT) provides a safe non-invasive approach to accurately delineate coronary artery anatomic structure. We report a case of a 6 years old boy with history of Kawasaki disease. Multi detector CT scan showed giant aneurysm at proximal LAD, proximal RCA and medium aneurysm at proximal LCX. Patient then treated with the anticoagulant therapy.
The Role of Cardiac Computed Tomography in Tetralogy of Fallot and Pulmonary Atresia Oktavia Lilyasari
Jurnal Kardiologi Indonesia Vol. 36, No. 1 Januari - Maret 2015
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.v36i1.443

Abstract

Congenital heart disease (CHD) occurs in about 6 to 8 of 1000 live births with the increasing prevalence can be attributed to major improvements in diagnosis and treatment. Imaging has an important role in diagnosis of CHD. It outlines anatomy and physiology, helps to refine management, evaluates the consequences of interventions and helps guide prognosis. However, no single available imaging modality fulfills these roles for all patients and diseases. Therefore, assessment for CHD must involve multimodalities that can be used in a complementary fashion, and that together are sensitive, accurate, reproducible, and cost effective, whilst minimizing harm.In previous years, the diagnosis and the treatment of congenital malformations have often depended on cardiac catheterization. In many institutions, cardiac catheterization still remains the gold standard against which other modalities are measured. In the past decade, however, imaging methodologies have increasingly shifted toward the use of less invasive and noninvasive techniques. Although echocardiography is the most commonly used imaging modality for diagnosis and follow-up of subjects with CHD, the evolution of cardiovascular magnetic resonance (MR) imaging and increasingly computed tomography (CT) does offer new ways to visualize the heart and the great vessels.
Age Criteria As Operative Mortality Predictor After Modified Blalock-Taussig Shunt muammar riyandi; oktavia lilyasari; dafsah arifa juzar; budi rahmat
Jurnal Kardiologi Indonesia Vol 40 No 1 (2019): Indonesian Journal of Cardiology: January-March 2019
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.v40i1.763

Abstract

Background: Modified Blalock-Taussig shunt (MBTS) is considered as a simple procedure but has a considerable operative mortality rate. Patient’s characteristics who underwent MBTS in Indonesia is quite different than other country. There was no predictor of operative mortality has been identified in Indonesian.Objectives: To compare mortality rate based on age criteria and to identify mortality and morbidity predictors after MBTS procedure.Methods: A retrospectively cohort study was conducted on 400 patients who underwent MBTS at National cardiovascular center Harapan Kita (NCCHK) between January 2013 and december 2017.Results: There were 32,1% death at age ≤ 28 days, 19,9% at age 29-365 days, 3,6% at age 366-1825 days and 8% at age > 1825 days. Body weight < 3 kg, haematocrite level > 45% before procedure and activated partial thromboplastine time level (aPTT) < 60 seconds were operative mortality  predictors. Postoperative morbidity rate was 32,9%. Packed red cell  transfusion (PRC) more than 6 ml/kg, mechanical ventilator use before procedure, prostaglandin E1 use before procedure, aPTT level less than 60 seconds after procedure were identified as postoperative morbidity predictors.Conclusion: Operative mortality rate significantly different among age criteria but it was not proven as an operative mortality predictors. Body weight < 3 kg increase mortality rate and haematocrite level higher than 45% and aPTT level less than 60 seconds decrease mortality rate. Postoperative morbidity predictors were PRC transfusion more than 6ml/kg, mechanical ventilator use before procedure, prostaglandine E1 use and aPTT level less than 60 seconds.
Pulmonary Doppler Notch Pattern in Relation with Pulmonary Vascular Resistance Index in Patients with Atrial Septal Defect Nurnajmia Curie Proklamartina; Radityo Prakoso; Oktavia Lilyasari; Rina Ariani; Sisca Natalia Siagian; Amiliana Mardiani Soesanto
Jurnal Kardiologi Indonesia Vol 41 No 3 (2020): Indonesian Journal of Cardiology: July - September 2020
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.1053

Abstract

Background: Atrial septal defect (ASD) potentially causes pulmonary hypertension (PH) and increased pulmonary vascular resistance (PVR). In previous studies, pulmonary Doppler notch was evident in patients with high PVR. There was a distinct notch pattern in different types of PH. This study aims to examine whether echocardiographic notch pattern could estimate PVR in secundum ASD patients. Methods: Cross sectional study was conducted in secundum ASD patients ≥18 years old who underwent clinically indicated right heart catheterization. Association of notch presence and PVR index (PVRi) and correlation of notch ratio (NR), a parameter of notch location, and PVRi were analyzed. The best cut off of NR value was obtained using the receiver operating characteristics curve. Results: Among 60 patients, the notch was present in 50 patients (83%) and significantly associated with PVRi ≥6 WU.m2 (p<0.0001). Notch ratio and PVRi had a moderate negative correlation (r=-0.410, p=0.003). Receiver operating characteristics curve with area under curve 0.709 showed that cutoff NR value of 1.635 was a good discriminator for PVRi ≥6 WU.m2, with 70% sensitivity, 70% specificity, 56.8% positive predictive value, and 14.9% negative predictive value. Patients were then classified into three groups of notch pattern based on its presence and location, which was significantly associated with PVRi (p<0.0001). Conclusions: Pulmonary Doppler notch pattern is associated with PVRi in secundum ASD patients. This may be used clinically to estimate PVR to aid patient selection for further invasive investigation. Keywords: atrial septal defect, Doppler echocardiography, notch, notch ratio, pulmonary vascular resistance
Pengaruh Tricuspid Annular Plane Systolic Excursion (TAPSE) Pasca Pembedahan Katup Mitral Terhadap Mortalitas Jangka Panjang Erriyanti, Sabrina; Soesanto, Amiliana M; Sakidjan, Indriwanto; Atmosudigdo, A.; Lilyasari, Oktavia; Ariani, Rina; Siagian, Sisca Natalia
Jurnal Kardiologi Indonesia Vol 43 No 1 (2022): Indonesian Journal of Cardiology: January - March 2022
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.1196

Abstract

Background: Heart valve disease is still a significant health burden in the world, including Indonesia. The postoperative outcome of mitral valve surgery is influenced by many things, including decreased right ventricular (RV) function, which is the most common complication. Several studies have shown that decreased RV function after mitral valve surgery is associated with long-term outcomes. TAPSE is a routine and easy measurement of RV systolic function. A decrease in TAPSE after cardiac surgery is common because of the effects of pericardiotomy, and does not necessarily reflect a decrease in RV ejection fraction (RVEF). Regardless of whether postoperative TAPSE values ​​indicate right ventricular systolic function or only due to the effects of pericardiotomy, it is still not clear whether postoperative TAPSE values ​​have a prognostic value to long-term mortality after mitral valve surgery. Therefore, the objective of this study is to obtain information regarding the relationship of TAPSE echocardiographic parameters after mitral valve surgery with long-term mortality. Methods: This is a retrospective cohort study, looking at the effect of TAPSE on outcome after mitral valve surgery. The analysis starts from the starting point of the study when the patient was discharged alive from the hospital after mitral valve surgery (operation period January 2016 – February 2017) to the end point of the study, which was June 30th, 2021 and the observed outcome was mortality from any cause. Results: Of the 266 study subjects, 11 subjects died within 4-5 years after mitral valve surgery, the mortality is 4%. Bivariate analysis was performed on several factors and no relationship was found between the analyzed variables and mortality. Conclusion: There is no relationship between mortality and TAPSE after mitral valve surgery. This article has a related Erratum.
FUZZY LOGISTIC REGRESSION APPLICATION ON PREDICTIONS CORONARY HEART DISEASE Febriani, Vera; Lestari, Dian; Mardiyati, Sri; Lilyasari, Oktavia
BAREKENG: Jurnal Ilmu Matematika dan Terapan Vol 17 No 1 (2023): BAREKENG: Journal of Mathematics and Its Applications
Publisher : PATTIMURA UNIVERSITY

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (416.119 KB) | DOI: 10.30598/barekengvol17iss1pp0571-0580

Abstract

According to the World Health Organization (WHO) in 2015, 70% of cardiac deaths were caused by coronary heart disease (CHD). Based on WHO data in 2017, 17.5 million deaths were recorded, equivalent to 30% of the total deaths in the world caused by coronary heart disease. Coronary heart disease is a disorder of heart function caused by plaque that accumulates in arterial blood vessels so that it interferes with the supply of oxygen to the heart tissue. This causes reduced blood flow to the heart muscle and oxygen deficiency occurs. In more serious circumstances, it can result in a heart attack. Risk factors for coronary heart disease include age, gender, hypertension, cholesterol, heredity, diabetes mellitus, obesity, dyslipidemia, smoking and lack of physical activity. If a person's chances of suffering from coronary heart disease can be predicted early based on the existing risk factors, then the mortality rate of coronary heart disease can be suppressed. The objective of this study is to build a model that can predict the possibility of a patient suffering from coronary heart disease. The study used the Fuzzy Logistic Regression model. This model was used to maximize prediction results in which data size was limited. The least square method was used to estimate the value of the parameter. We obtained from National Cardiovascular Center Harapan Kita, Jakarta. Evaluation with the Mean Degree of Membership method showed that the model built was feasible and good enough to predict coronary heart disease. By using the confusion matrix, the accuracy of the prediction model is 80.00%, with a specificity of 42.85% and a sensitivity of 100%.
Co-Authors A. Atmosudigdo Adrianus Kosasih Adrianus Kosasih Amiliana M Soesanto Amiliana M Soesanto Amiliana Mardiani Soesanto Andang H Joesoef Anna Ulfah Rahajoe Ariani, Rina Ariyanti, Novi Asmuni, Melyana Atmosudigdo, A. budi rahmat Dafsah Arifa Juzar DIAN LESTARI Dya Pratama Andryan Erriyanti, Sabrina Febriani, Vera Ganesja M Harimurti Hardjosworo, Arinto Bono Adji Husink, Aron Indriwanto Sakidjan Ismoyo Sunu muammar riyandi Nur Haryono Nurnajmia Curie Proklamartina Poppy S Roebiono Radityo Prakoso Richard Indra Gunawan Richard Indra Gunawan Rina Ariani Rina Ariani RWM Kaligis Sabrina Erriyanti Sisca Natalia Siagian Sisca Natalia Siagian Sri Mardiyati Susandy Oetama