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All Journal Indonesian Journal of Cardiology
Arina Madjidi
Departemen Kardiologi dan Kedokteran Vaskular, Fakultas Kedokteran Universitas Brawijaya – Rumah Sakit Umum dr.Saiful Anwar
Health Professions Medicine & Pharmacology

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Kadar Gula Darah Lebih Tinggi pada Pasien Hipertensi dengan Delesi Intron 16 Gen Ace Lowry Yunita; Mohammad Saifur Rohman; Bagus H Kuncahyo; Mifetika Lukitasari; Arina Madjidi; Maulidiyatun Nuril Faizah; Nashi Widodo
Jurnal Kardiologi Indonesia Vol. 37, No. 1 Januari - Maret 2016
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.v37i1.551

Abstract

Background Renin Angiotensin Aldosteron System plays major role in hypertension pathophysiology. Has been proposed that half of individuals with essential hypertension are considered insulin resistant. Angiotensin Converting Enzyme gene polymorphism taking the control of ACE level in human plasma. There might be a correlation between ACE gene polymorphism and plasma glucose level.Objective This study sought to investigate ACE gene polymorphism insertion/deletion in hypertensive patients and its correlation with plasma glucose level.Method A total of 100 hypertensive patients at Saiful Anwar cardiovascular outpatients clinic who received ACEi at least 8 weeks were included. ACE genotype were determined by polymerase chain reaction method, and plasma glucose level was measured by enzymatic colorimetric assay method.Result The II, ID, and DD genotype were observed in 48%, 29% and 23% of participant, respectively. The fasting and 2 hours post prandial plasma glucose were significantly higher in DD genotype patients. The insertion/deletion polymorphisms were not related significantly to age, sex, cough, and controlled blood pressure of those patients.Conclusion This study showed that 23% of hypertensive patients had DD genotype with higher plasma glucose level as compare to those of II and ID genotype.
Co-Authors Bagus H Kuncahyo Lowry Yunita Maulidiyatun Nuril Faizah Mifetika Lukitasari Mohammad Saifur Rohman Nashi Widodo