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All Journal Jurnal Penelitian Pendidikan IPA (JPPIPA) Journal of Pharmaceutical and Health Research Jurnal Novem Medika Farmasi
Ermina Pakki
Fakultas Farmasi, Universitas Hasanuddin, Makassar
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health

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Formulasi dan Uji Stabilitas Fisik Sediaan Gel Ekstrak Etanol Daun Rambutan (Nephelium Lappaceum L.) Astriani, Andi Dian; Fitriani, Ana; Pakki, Ermina
Journal of Pharmaceutical and Health Research Vol 4 No 3 (2023): October 2023
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v4i3.3412

Abstract

The ethanol extract of rambutan leaves has anti-Staphylococcus aureus properties. The purpose of this investigation is to formulate the ethanol extract of rambutan leaves (Nephelium lappaceum L.) in order to determine the stable concentration of carbopol 940 for gel preparations. The extraction technique utilised was maceration with 96% ethanol. Formula 1 (0.7% carbopol 940), Formula 2 (0.9% carbopol 940), and Formula 3 (1.1% carbopol 940) were developed for the gel preparation formulation. Organoleptic assays, homogeneity, spreadability, pH, and adhesion were conducted before and after accelerated storage at 400°C and 75% relative humidity. The results of the organoleptic test revealed that preparations F1, F2, and F3 had a semi-solid consistency, a dark brown hue, and a distinct extract odour, and that they were homogeneous. Before accelerated conditions, the spreadability test yielded Farmula 1 (6,3 cm), Farmula 2 (5,96 cm), and Farmula 3 (5.3 cm). After accelerated conditions, the results were F1 (5.86cm), F2 (5.43cm), and F3 (5.16cm). Before the accelerated condition, the pH test results were F1 (5.54), F2 (5.91), and F3 (6.00). After the accelerated condition, the results were F1 (6.43), F2 (6.08), and F3 (5.76). The adhesion test before the accelerated condition yielded F1 (4.37 seconds), F2 (4.28 seconds), and F3 (4.45 seconds), and after the accelerated condition yielded F1 (4.57 seconds), F2 (4.38 seconds), and F3 (4.66 seconds of data, it can be concluded that the gel formulation of rambutan leaf extract from various concentrations of 0.7%, 0.9%, and 1.1% carbopol 940 is physically stable.
Toothpaste Formulation Ethanol Extract Mangosteen Peel (Garcinia mangostana L.) and Test Activity Against Candida albicans Junuda, Nur Khairun Nisa; Pakki, Ermina; Ida, Nur
Jurnal Penelitian Pendidikan IPA Vol 9 No 6 (2023): June
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v9i6.3623

Abstract

The mangosteen peel contains phenol compounds that have antifungal activity. The study aimed to find out the antifungal activity in the dosage form of toothpaste against Candida albicans. The research methods used include the extraction of mangosteen peel (Garcinia mangostana L.) by maceration using 96% ethanol. The toothpaste formula was composed with an extract concentration of 1.25% (F1); 2.5% (F2); 5% (F3); and base (B). Antifungal testing was carried out by diffusion method using Potato Dextrose Agar (PDA) media. The results showed that the toothpaste formula with a concentration of F1; F2; F3; and base (B) has an average value of successive inhibition zone diameters of 11.86 mm; 12.03mm; 12.54mm; and 7.78 mm. The conclusion of the study showed that the toothpaste preparation of the ethanol extract of mangosteen fruit peel (Garcinia mangostana L.) concentration was 1.25%; 2.5%; 5% which performs antifungal activity.
Uji Aktivitas Antioksidan dan Skrining Fitokimia Ekstrak Etanol Rumput Laut Merah (Eucheucma cottonii) Asal Kabupaten Polewali Mandar Hanisa, Nur; Pakki, Ermina; Zam Zam, Andi Nur
Jurnal Novem Medika Farmasi Vol. 3 No. 3 (2024): volume 3 Issue 3 2024
Publisher : Program Studi Farmasi, Universitas Islam Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59638/junomefar.v3i3.1371

Abstract

Rumput Laut Merah (Eucheuma cottonii) merupakan salah satu rumput laut merah yang berpotensi sebagai sumber antioksidan alami. Antioksidan merupakan suatu senyawa yang dapat menyerap atau menetralisir radikal bebas sehingga mampu mencegah penyakit. Senyawa di dalam rumput laut merah yang dapat bersifat sebagai antioksidan adalah flavonoid. Tujuan dari penelitian ini yaitu melakukan skrining fitokimia dan menentukan aktivitas antioksidan ekstrak etanol 70% dan 90% rumput laut merah (Eucheuma cottonii). Yang diperoleh dari perairan Desa Ujung, Kecamatan Polewali Kabupaten Polewali Mandar. Metode Penelitian meliputi ekstraksi dengan metode maserasi, dilanjutkan skrining fitokimia dan uji aktivitas antioksidan dengan metode DPPH menggunakan spektrofotometer UV-Vis pada panjang gelombang visible 505 nm. Hasil uji skrining fitokimia menggunakan pelarut etanol 70% dan 90% positif mengandung golongan senyawa alkaloid, flavanoid, fenolik, saponin, dan triterpenoid diperoleh hasil rendemen ekstrak etanol 70 yaitu 10,45% dan 90 yaitu 11,68%. Uji aktivitas antioksidan ekstrak sampel masing-masing didapatkan nilai IC50 yaitu 11,553 ppm dan 9,045 ppm dikategorikan sebagai antioksidan sangat kuat. Kemampuan aktivitas antioksidan tertinggi diperoleh pada ekstrak etanol rumput laut merah (Eucheuma cottonii) dengan konsentrasi 90%.
Co-Authors Astriani, Andi Dian Fitriani, Ana Hanisa, Nur Junuda, Nur Khairun Nisa Nur Ida Zam Zam, Andi Nur