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All Journal Jurnal Penelitian Pendidikan IPA (JPPIPA) Journal Syifa Sciences and Clinical Research (JSSCR) Jurnal farmasi UIN Alauddin Makassar Journal of Pharmaceutical and Health Research KLOROFIL: Jurnal Ilmu Biologi dan Terapan Medical Sains : Jurnal Ilmiah Kefarmasian
Astriani, Andi Dian
Program Studi S1 Farmasi, Fakultas MIPA, Universitas Islam Makassar, Makassar, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health

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UJI AKTIVITAS ANTIMIKROBA ACTINOMYCETES DARI TANAH PERAKARAN KUNYIT PUTIH (CURCUMA ZEDOARIA) Andi Dian Astriani
Jurnal Farmasi UIN Alauddin Makassar Vol 6 No 1 (2018): Jurnal Farmasi
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/jurfar.v6i1.6742

Abstract

Secara historis, Actinomycetes menghasilkan jumlah terbesar calon obat antibiotik baru. Penelitian ini bertujuan untuk mengisolasi Actinomycetes dari tanah perakaran kunyit putih yang berpotensi sebagai antimikroba. Metode yang digunakan dalam penelitian ini adalah metode experimental laboratory. Teknik pengumpulan data yaitu dengan uji daya hambat Actinomycetes yang telah diisolasi terhadap bakteri uji yaitu Eschericia coli dan Staphyloccocus aureus dan fungi Candida albicans untuk mengetahui adanya potensi antimikroba. Teknik analisis data yang digunakan yaitu dengan mengukur zona hambat yang terbentuk. Berdasarkan hasil uji daya hambat, dari 4 isolat, hanya 1 isolat yang mampu menghambat pertumbuhan bakteri Eschericia coli dan Candida albicans. Pemeriksaan ornamen rantai spora menunjukkan bahwa isolat tersebut adalah Actinomycetes.
Uji Aktivitas Antibakteri Mikroba Endofit Dari Buah Merah (Pandanus conoideus Lam.) terhadap Bakteri Patogen Andi Dian Astriani; Endah Dwijayanti
Journal Syifa Sciences and Clinical Research Vol 4, No 2 (2022): Volume 4 Edisi 2 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i2.14369

Abstract

Endophyte microbes can produce bioactive compounds that can be used as medicinal raw materials. Red fruit is one of the typical fruits that grow in the Papua area that has a potential bioactive compound content but has not been widely studied. So the study aimed to isolate endophyte microbes from red fruits (Pandanus conoideus Lam.) and determine activity against pathogenic microbes. The study began with the isolation of endophytic microbes from red fruit plants (Pandanus conoideus Lam.) using medium Nutrient Broth and Potato Dextrose Broth to obtain endophyte bacteria and fungi, once isolated and purified, pure microbes are inoculated in a medium to tilt. To maximize secondary metabolites, each microbe is fermented for 14 days. Supernatan fermentation results are tested antibacterial activity against test bacteria by the method of diffusion agar.  The test microbes used are Eschericia coli, Staphylococcus aureus, Salmonella thyposa, Streptococcus mutans, Candida albicans.  Positive endophyte microbes inhibit fermented pathogenic bacteria to maximize the production of their secondary metabolitesMikroba endophyte which has the ability to inhibit pathogenic bacteria characterized macroscopically and microscopically. From the results of the study, 4 endophyte microbes were produced, 2 in the form of molds, and 2 microbes from bacteria. From the results of the study, bakery N2, can inhibit the bacteria E.coli, S. mutans, S, aureus, S. thyposa. Gram staining, indicating N2 is gram negative bacteria. So it can be concluded that the N2 endophyte bacteria of red fruit (Pandanus conoideus Lam.), have bioactive compounds that can inhibit pathogenic microbes.
UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL 70% KLIKA TURI (Sesbania grandiflora L.) TERHADAP Staphyloccous epidermidis DAN Propionibacterium acnes Andi Dian Astriani
KLOROFIL: Jurnal Ilmu Biologi dan Terapan Vol 7, No 1 (2023): KLOROFIL: JURNAL ILMU BIOLOGI DAN TERAPAN
Publisher : Program Studi Biologi Fakultas Sains dan Teknologi Universitas Islam Negeri Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30821/kfl:jibt.v7i1.13519

Abstract

Acne is a skin disease that occurs due to bacterial infection, usually on the skin surface of the face, neck, chest, and back. The Turi plant is one plant with medicinal properties that can be used as an antibacterial. This study aims to determine the antibacterial activity of 70% ethanol extract of klika turi against Staphylococcus epidermidis and Propionibacterium acnes. Klika turi was extracted by reflux method using 70% ethanol solvent. They were testing the antibacterial activity of 70% ethanol extract against Staphylococcus epidermidis and Propionibacterium acnes using liquid dilution and agar diffusion methods. The results showed that the MIC values were 2.5% against Staphylococcus epidermidis and 5% against Propionibacterium acnes. Activity test with the diffusion method to obtain the diameter of the inhibition zone against Staphylococcus epidermidis at an extract concentration of 2.5%; 5%; 10%; and 20%, which is 7.35 mm; 8.67mm; 11.08 mm and 11.55 mm, while for Propionibacterium acnes at an extract concentration of 5%; 10%; and 20% obtained the diameter of the inhibition zone which is 8.77; 11.32mm; and 12.00mm. The results can be concluded that the 70% ethanol extract of klika Turi has effective antibacterial activity at a concentration of 10% against Staphylococcus epidermidis and Propionibacterium acnes.).
CHARACTERIZATION AND ANTIBACTERIAL ACTIVITY TEST OF HONEY, LEMON, GINGER FERMENTATION AGAINST BACTERIA CAUSING ACUTE RESPIRATORY INFECTIONS (ARI) Andi Dian Astriani; Muhammad Iqbal
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 2 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i2.931

Abstract

Acute respiratory infection (ARI) is a disease that attacks one or more parts of the airway, from the nose to the alveoli. The most common bacteria found in the samples of patients with ARI were Streptococcus pneumonia, Staphylococcus aureus, and Klebisilia pneumonia. Honey contains flavonoids, amino acids and potassium as antibiotics that are bactericidal (kill bacteria) and bacteriostatic (inhibit bacterial growth). Gingerol in ginger (Zingiber officinale) and lemon (Citrus limon) has antibacterial activity. Honey fermentation is believed to have great potential as an antibacterial compound. This study aimed to determine the inhibitory activity and physical characteristics of fermented honey, lemons, and ginger against ARI bacteria. The test bacteria used were Streptococus pneumonia, Stahpylococcus aureus, and Klebsilia pneumonia. Fermentation of honey, lemon, and ginger was performed with variations in fermentation time (days 1, 3, 5, and 7) and honey without fermentation to determine the effect of fermentation time on inhibitory activity. The inhibition activity was tested using the agar diffusion method. Measurement of inhibition diameter using a caliper. Determination of ginger lemon fermented honey characteristics, including water content, sucrose content, and total sugar content, using gravimetric and titrimetric methods. Based on the activity test, honey fermented for 1 day had the greatest inhibitory activity of 9.71 mm; 9.20 mm; and 9.86 mm against Stahpylococcus aureus, Staphylococcus pneumonia, Klebsilia pneumonia compared to honey fermented for 3 days, 5 days, 7 days and honey without fermentation. ...
Formulasi dan Uji Stabilitas Fisik Sediaan Gel Ekstrak Etanol Daun Rambutan (Nephelium Lappaceum L.) Astriani, Andi Dian; Fitriani, Ana; Pakki, Ermina
Journal of Pharmaceutical and Health Research Vol 4 No 3 (2023): October 2023
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v4i3.3412

Abstract

The ethanol extract of rambutan leaves has anti-Staphylococcus aureus properties. The purpose of this investigation is to formulate the ethanol extract of rambutan leaves (Nephelium lappaceum L.) in order to determine the stable concentration of carbopol 940 for gel preparations. The extraction technique utilised was maceration with 96% ethanol. Formula 1 (0.7% carbopol 940), Formula 2 (0.9% carbopol 940), and Formula 3 (1.1% carbopol 940) were developed for the gel preparation formulation. Organoleptic assays, homogeneity, spreadability, pH, and adhesion were conducted before and after accelerated storage at 400°C and 75% relative humidity. The results of the organoleptic test revealed that preparations F1, F2, and F3 had a semi-solid consistency, a dark brown hue, and a distinct extract odour, and that they were homogeneous. Before accelerated conditions, the spreadability test yielded Farmula 1 (6,3 cm), Farmula 2 (5,96 cm), and Farmula 3 (5.3 cm). After accelerated conditions, the results were F1 (5.86cm), F2 (5.43cm), and F3 (5.16cm). Before the accelerated condition, the pH test results were F1 (5.54), F2 (5.91), and F3 (6.00). After the accelerated condition, the results were F1 (6.43), F2 (6.08), and F3 (5.76). The adhesion test before the accelerated condition yielded F1 (4.37 seconds), F2 (4.28 seconds), and F3 (4.45 seconds), and after the accelerated condition yielded F1 (4.57 seconds), F2 (4.38 seconds), and F3 (4.66 seconds of data, it can be concluded that the gel formulation of rambutan leaf extract from various concentrations of 0.7%, 0.9%, and 1.1% carbopol 940 is physically stable.
Activity Test of Extract Edible Bird’s Nest (Aerodramus fuciphagus) as a Natural Treatment to Lower LDL Levels Musdalifah; Zam, Andi Nur Zam; Astriani, Andi Dian
Jurnal Penelitian Pendidikan IPA Vol 11 No 8 (2025): August
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v11i8.12255

Abstract

This study aimed to evaluate the effect of edible bird’s nest (EBN) infusion (Aerodramus fuciphagus) on lowering low-density lipoprotein (LDL) levels in white rats (Rattus norvegicus) induced with hypercholesterolemia. Fifteen male Wistar rats were divided into five groups: negative control (distilled water), positive control (simvastatin 10 mg/kg BW), and three treatment groups receiving EBN infusion at doses of 10, 20, and 40 mg/200 g BW. LDL levels were measured before and after treatment using an enzymatic colorimetric method. The results showed that EBN infusion reduced LDL levels in all treatment groups, with the highest decrease at a dose of 40 mg/200 g BW (34.03%), followed by 20 mg (33.46%) and 10 mg (28.13%). Simvastatin, however, produced a greater LDL reduction (55.64%). In conclusion, EBN infusion can reduce LDL levels in hypercholesterolemic rats, particularly at doses of 20 mg/200 g BW, suggesting its potential as a natural lipid-lowering agent, although it is less effective than simvastatin.
Co-Authors andi nur zam zam Endah Dwijayanti Ermina Pakki Fitriani, Ana Muhammad Iqbal Musdalifah Musdalifah