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All Journal Jambura Journal of Health Sciences and Research Jurnal Ners
kewin gozali
Universitas Prima Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Nursing Public Health

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ACUTE TOXICITY OF EXTRACT OF WHITE TURMERIC RHIZOME (CURCUMA ZEDOARIA) REVIEW OF LD50 AND BLOOD CELL COMPONENTS kewin gozali; Tandanu Erny; Wardhani Maya Fiska; Schram Alexander Rico
Jambura Journal of Health Sciences and Research Vol 4, No 3 (2022): OKTOBER: JAMBURA JOURNAL OF HEALTH SCIENCES AND RESEARCH
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35971/jjhsr.v4i3.13309

Abstract

Kunyit putih (Curcuma zedoaria) merupakan tanaman obat tradisional memiliki kandungan fitokimia yang dipercaya penggunaannya sebagai anti atherosklerosis, anti-diabetes, anti-oksidatif, anti inflamasi serta anti kanker. Akan tetapi belum ada penelitian mengenai efek samping tanaman obat tersebut. Kebaruan dalam penelitian ini karena meneliti toksisitas akut ekstrak rimpang kunyit putih ditinjau dari LD50 dan komponen sel darah. Penelitian ini bertujuan untuk menguji toksisitas akut ekstrak rimpang kunyit putih pada komponen sel darah. Kajian ini memakai 30 ekor tikus putih (Rattus novergicus) dan dikelompokkan ke dalam 6 kelompok (kelompok NaCMC 1%, kelompok normal, kelompok perlakuan 250mg/KgBB, 500 mg/KgBB, 750 mg/KgBB, dan 2000mg/KgBB). Parameter komponen sel darah yang diamati setelah 14 hari perlakuan adalah kadar eritrosit, leukosit, trombosit dan hemoglobin. Data yang terkumpul kemudian dianalisa dengan tes one-way ANOVA serta dilanjut memakai uji PostHoc. Dari hasil kajian ini bisa disimpulkan jika Ekstrak rimpang kunyit putih tidak menyebabkan gejala toksisitas dan mortalitas pada tikus Kata kunci : Kunyit putih; uji toksisitas akut; eritrosit; leukosit; trombosit; hemoglobin. AbstractWhite turmeric (Curcuma zedoaria) is a traditional medicinal plant that contains phytochemicals which are believed to be used as a anti-atherosclerosis, anti-diabetic, anti-oxidative, anti-inflammatory and anti-cancer. Currently there are no studies on the side effects of these medicinal plants. The novelty in this study is because it examines the acute toxicity of white turmeric rhizome extract in terms of LD50 and blood cell components. This research aims to test the acute toxicity of white turmeric rhizome extract on blood cell components. This research use 30 white rats (Rattus novergicus) and grouped into 6 groups (normal group, 1% NaCMC group, treatment group 250mg/KgBW, 500 mg/KgBW, 750 mg/KgBW, and 2000mg/KgBW). Parameters of blood cell components observed after 14 days of treatment were the levels of erythrocytes, leukocytes, platelets and hemoglobin. The collected data was then analyzed use the one-way ANOVA test and then tested by the PostHoc test. From the results of this study, it can be concluded that white turmeric (Curcuma zedoaria) rhizome extract did not cause symptoms of toxicity and mortality in rats .Keywords : white turmeric; acute toxicity test; erythrocytes; leukocytes; platelets; hemoglobin.
Analisis Penyelenggaraan Sistem Pemeliharaan Alat Radiologi Rsu Royal Prima Medan Kewin Gozali; Ermi Girsang; Putranto Manalu
Jurnal Ners Vol. 10 No. 2 (2026): APRIL 2026
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v10i2.55191

Abstract

Hospitals as providers of professional, high-quality, and sustainable health services require adequate support from standardized medical equipment, including in the radiology unit. Radiology equipment must be systematically maintained to ensure optimal functionality, produce accurate diagnostic results, and foster patient satisfaction as well as positive public perceptions of the hospital. This study aimed to analyze the implementation of the radiology equipment maintenance system at RSU Royal Prima Medan. This research employed a qualitative design, with primary data obtained through in-depth interviews with relevant informants. Data analysis was conducted using triangulation, followed by data reduction, data presentation, and conclusion drawing. The results showed that, in terms of input, the maintenance of radiology equipment at RSU Royal Prima Medan was supported by the availability of adequate and functional facilities and infrastructure, a sufficient number of human resources, and personnel with appropriate expertise and knowledge according to their respective roles and responsibilities. The maintenance budget was available, although the exact amount was not clearly specified. In terms of process, maintenance activities were carried out routinely, including daily cleaning and comprehensive inspections every six months to assess equipment feasibility. All maintenance procedures were implemented in accordance with the established Standard Operating Procedures (SOPs). In terms of output, all radiology equipment at RSU Royal Prima Medan was in good, normal, and operational condition, enabling accurate diagnostic examinations. In conclusion, the radiology equipment maintenance system at RSU Royal Prima Medan has been implemented effectively and in compliance with established SOPs.
Co-Authors Ermi Girsang Putranto Manalu Schram Alexander Rico Tandanu Erny Wardhani Maya Fiska