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All Journal JBIO: jurnal biosains (the journal of biosciences) Journal of Biomedicine and Translational Research Indonesian Journal of Pharmaceutical Science and Technology Majalah Obat Tradisional BIOLINK (Jurnal Biologi Lingkungan, Industri, Kesehatan) Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan Jurnal Penelitian Pendidikan IPA (JPPIPA) Jambura Journal of Health Sciences and Research Jurnal Kesehatan Global Journal of Health Sciences JURNAL KEBIDANAN KESTRA (JKK) Jurnal Maternitas Kebidanan Jurnal Pendidikan dan Konseling Journal of Telenursing (JOTING) INFOKUM Jurnal Kesehatan Saintika Meditory PRIMER (Prima Medical Journal) Jurnal Ekonomi JUMANTIK (Jurnal Ilmiah Penelitian Kesehatan) Cerdika: Jurnal Ilmiah Indonesia
Ermi Girsang
Universitas Prima Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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EFFECTIVENESS TEST OF BLACK CUMIN SEEDS (NIGELLA SATIVA) EXTRACT ON THE GROWTH OF KLEBSIELLA PNEUMONIAE AND PSEUDOMONAS AERUGINOSA BACTERIA Nadya Nazimuddin Putri; Linda Chiuman; Chrismis Novalinda Ginting; Ermi Girsang
BIOLINK (Jurnal Biologi Lingkungan Industri Kesehatan) Vol 7, No 2 (2021): February 2021
Publisher : Universitas Medan Area

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31289/biolink.v7i2.3702

Abstract

Black cumin seeds are known to have beneficial contents as antibacterial. This study aimed to determine the effectiveness of black cumin seed extract (Nigella sativa) on the growth of Klebsiella pneumoniae and Pseudomonas aeruginosa. The method used was the disc diffusion method. The ethanol extract of black cumin seeds gain by maceration method and was made into various concentration (5, 7.5, 10, 12.5, and 15)%. For positive control, ciprofloxacin disc were used and negative control used distilled water. The research model used was in vitro experimental research. The results showed that ethanol extract of black cumin seeds have antibacterial activity against Klebsiella pneumoniae with inhibition zone diameters (4.5, 6.7, 10.1, 11, 12.8) mm, Pseudomonas aeruginosa with inhibition zone diameters (7.5, 12, 12.6, 13.4, 15.6) mm, positive controls respectively (24.3 and 20.7) mm and negative controls (0). It can be concluded that black cumin seed extract has an inhibiting effect on the growth of Klebsiella pneumoniae and Pseudomonas aeruginosa.
EFFECTIVENESS TEST OF ANTI-BACTERIAL LIME JUICE (Citrus aurantifolia) ON SALMONELLA SP BACTERIA IN SALMON FISH (Oncorhynchus nerka) Qori Fadillah; Linda Chiuman; Chrismis Novalinda Ginting; Ermi Girsang
BIOLINK (Jurnal Biologi Lingkungan Industri Kesehatan) Vol 7, No 1 (2020): August 2020
Publisher : Universitas Medan Area

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (444.003 KB) | DOI: 10.31289/biolink.v7i1.3322

Abstract

Salmonella Sp is a gram-negative pathogens that are often found in marine foods,one of  process of serving  salmon is channeling lime juice, where lime juice is acidic and has phytochemical properties that have anti-bacterial properties. This study aims to explore anti-bacterial effect lime juice on Salmonella thypii bacteria in Salmon. This research is an experimental study using  disc diffusion method. Lime samples that were used were purchased from one of the modern markets in Medan which were made in several series of concentrations using distilled water as a solvent, while the salmon samples used in this study were purchased from one of the Japanese dining restaurants located in Medan City. Meanwhile, isolation of Salmonella thypii bacteria from salmon samples was carried out using nutrient broth and SSA media. The results of this study indicate that differences in concentration indicate the differences in the diameter of the inhibitory zone (P value = 0.000). With the diameter of the widest inhibition zone formed by a concentration of 100% is 15.40 ± 0.44 mm and the smallest diameter is formed by a concentration of 5% which is 7.23 ± 0.55 mm. Thus, it can be concluded that the lime juice has anti-bacterial activity against Salmonella thypii bacteria from salmon.
ANALISIS DETERMINAN DAN PREDIKSI PENYAKIT DIABETES MELITUS TIPE 2 MENGGUNAKAN METODE MACHINE LEARNING: SCOPING REVIEW Rapael Ginting Ginting; Ermi Girsang; Johannes Bastira Ginting; Hartono Hartono
Jurnal Maternitas Kebidanan Vol. 7 No. 1 (2022): Jurnal Maternitas Kebidanan
Publisher : Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jumkep.v7i1.2538

Abstract

ABSTRACT The prevalence of diabetes mellitus is increasing globally, nationally, and regionally, and most of them are type 2 diabetes mellitus, which can cause complications, economic losses, and death. The purpose of this study is to examine the analysis of determinants and predictions of type 2 diabetes mellitus using machine learning methods. This study uses the scoping review method to view, accumulate and synthesize the results of previous studies on the analysis of determinants and predictions of type 2 diabetes mellitus using machine learning methods. The inclusion criteria in this study were articles published in the indexed journal database PubMed, Google Scholar, Crossref in English and Indonesian, journals published in the 2017-2021 range and 15 articles that met the inclusion criteria. The search results were a total of 860 articles from 3 databases (PubMed, Google Scholar, Crossref) in which 98 of them were duplicate articles and were excluded. Of the remaining 762 articles, 142 were not full text and 605 were excluded after eligibility screening because they were irrelevant. The remaining 15 articles were systematically reviewed and qualitatively analyzed using the NVIVO-12 Plus application. From the analysis of previous studies concluded that age, obesity, family history of disease, and lack of physical activity are risk factors for type 2 diabetes mellitus, while the gender variable from the analysis of previous research shows that there is no significant relationship between gender and type 2 diabetes. With early prediction of type 2 diabetes mellitus preventive measures, treatment can be carried out immediately and reduce the incidence of complications that can worsen the condition of people with type 2 diabetes.    
The Effectiveness of Aloe vera Hydrogel Against Fusobacterium nucleatum Chandra Susanto; Ermi Girsang
Indonesian Journal of Pharmaceutical Science and Technology Vol 7, No 3 (2020)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v7i3.26618

Abstract

Bacteria can cause infectious diseases on oral health such as gingivitis and periodontitis. Scaling and rootplaning are effective against this disease, nevertheless several types of antimicrobial material can be added to increase the effectiveness of the initial treatment. Aloe vera is one of the natural antimicroba materials that is usually used. Hydrogel is a polymetric material that is stable in wet conditions, especially in the gingival sulcus. Sodium alginate is a natural polymer that is often used to produce hydrogels due to its biocompability. The aim of this study was to know the the effectiveness of Aloe vera hydrogel against Fusobacterium nucleatum by in vitro method. This research is experimental research with a total of 20 samples. The samples used were 5% and 10% sodium alginate based Aloe vera hydrogel which were placed in pure culture of F. nucleatum in MHA media for 24 hours. The inhibition zone diameter were measured using calipers. The results of the study using Shapiro-Wilk normality test showed that the data were not normally distributed. Then Kruskal Wallis test was performed which showed significant differences in each treatment group followed by Post Hoc Mann Whitney test to see a significant difference in the 5% group and 10%. Aloe vera hydrogel showed a significant inhibition against F. nucleatum bacteria at both 5% and 10% concentrations.Keywords: Alginate, Aloe vera, Antimicrobial material, Fusobacterium nucleatum, Hydrogel, Inhibitory zone
UJI EFEKTIVITAS EKSTRAK DAUN PETAI CINA (Leucaena leucocephala) UNTUK MENGHAMBAT PERTUMBUHAN Staphylococcus aureus Axel Valerian; Ermi Girsang; Sri Lestari Rahamdhani Nasution; Sri Wahyuni Nasution
JBIO: jurnal biosains (the journal of biosciences) Vol 5, No 2 (2019): Jurnal Biosains
Publisher : Universitas Negeri Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24114/jbio.v5i2.12777

Abstract

Staphylococcus aureus merupakan penyebab infeksi tersering pada manusia. Hampir setiap orang mengalami infeksi Staphylococcus aureus semasa hidupnya. Staphylococcus aureus juga menghasilkan enterotoxin yang menyebabkan terjadinya food poisoning dan toxic shock syndrome. Resistensi Staphylococcus aureus terhadap antibiotik telah banyak dilaporkan. Penggunaan antibiotik β-lactam seperti methicillin, oxacillin, dan amoxicillin yang berlebihan pada decade terakhir menyebabkan munculnya methicillin resistant Staphylococcus aureus (MRSA). Resistensi ini menyebabkan gangguan pengobatan sehingga diperlukan usaha untuk mengembangkan pengobatan tradisional.                Tujuan dari penerlitian ini untuk mengetahui efektivitas ekstrak daun petai cina (Leucaena leucocephala) dalam menghambat pertumbuhan Staphylococcus aureus. Penelitian ini menggunakan desain eksperimental laboratorik dengan metode disc diffusion. Ekstraksi dilakukan dengan cara maserasi menggunakan pelarut etanol 96%. Konsentrasi yang diuji pada Staphylococcus aureus dengan menggunakan ekstrak ekstrak daun petai cina (Leucaena leucocephala) sebesar 25%, 50%, 75%, dan 100%. Hasil penelitian ini menunjukkan bahwa ekstrak daun petai cina (Leucaena leucocephala) menghasilkan zona hambat seluas 10.525 mm, 11.475 mm, 12.725 mm, dan 16.85 mm pada konsentrasi 25%, 50%, 75%, dan 100%.
Antioxidants and Antityrosinase Activity of Ethanolic Basil Leaves Extract (Ocimum americanum L.) and Eygenol Dio Damara Handoyo; Ermi Girsang; Ali Napiah Nasution; I Nyoman Ehrich Lister
Majalah Obat Tradisional Vol 26, No 2 (2021)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.56081

Abstract

Harm effect from UV light, both UV-A and UV-B is contributing as a disease trigger and has an impact on human health. To investigate the bioactive compound, antioxidant, and the potential of basil leaves as antiaging sources particularly as the tyrosinase inhibitor. This study used phytochemical screening for the bioactive compound, DPPH scavenging activity for antioxidant assay, and tyrosinase inhibition activity for the antiaging property. The phytochemical screening shows that the basil leaves extract has flavonoid, saponin, phenol, steroid, and alkaloid. The basil leaves extract has lower antioxidant activity (20.55 ± 0.04 μg/mL) compared with eugenol (2.44 ± 0.26 μg/mL) through DPPH scavenging activity. The basil leaves extract (35.59 ± 0.83 μg/mL) has lower antiaging activity particularly as antityrosinase activity compared with eugenol (10.87 ± 0.41 μg/mL). Our findings suggest that basil leaves can be used as an antioxidant and antiaging source, particularly as a tyrosinase inhibitor.
Antioxidant and Elastase Inhibitor from Black Soybean (Glycine max L.) and Its Compound (Daidzein) Cendy Juliana; I Nyoman Ehrich Lister; Ermi Girsang; Ali Napiah Nasution; Wahyu Widowati
Journal of Biomedicine and Translational Research Vol 6, No 1 (2020): April 2020
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jbtr.v6i1.5540

Abstract

Background: Skin aging occurs along with age. Genetic, nutrients, hormones, and sun exposure can affect directly and indirectly the structure of the skin. These things will induce an increase in free radicals which disrupts one of the most important enzymes in the extracellular matrix which is elastase enzyme. High enzyme synthesis will cause skin wrinkle. Free radicals can be inhibited by the presence of antioxidants. The plant contains natural phytochemical compounds which act as antioxidants and anti aging. Black soybeans are rich in daidzein compound, which protect against free radicals and prevent premature aging.Objective: This research evaluates the antioxidant and antiaging potential of Black Soybean (Glycine max L.) extract and its compound, daidzein.Methods: Analysis of antioxidants from black soybean extract and daidzein were carried out using ABTS scavenging activity assay. The antiaging assay was carried out through inhibition of elastase enzyme.Results: Black soybean extract had lower IC50 value of ABTS scavenging activity around 77.39±4.05 μg/ml better than daidzein with IC50 of 83.34±3.89 μg/ml. The results of elastase inhibition activity assay showed that daidzein compound has a lower IC50 value, 57.35±5.64 μg/ml compared to black soybean extract with IC50 value, 93.36±6.39 μg/ml.Conclusion: Black soybean extract had higher antioxidant. Daidzein had better elastase inhibition activity compared to black soybean extract.
PHOTOCHEMICAL TEST OF PHALERIA MACROCARPA ROOT STEM FRUIT SEED EXTRACT Ali Napiah Nasution; Ermi Girsang; Jerry Fidelio Susanto; Yogie Chandra; Aldi Tambunan; Tiara Nabila Nabati; Susi Susanti
Jambura Journal of Health Sciences and Research Vol 4, No 3 (2022): OKTOBER: JAMBURA JOURNAL OF HEALTH SCIENCES AND RESEARCH
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35971/jjhsr.v4i3.12253

Abstract

Mahkota dewa atau Phaleria macrocarpa dari keluarga Thymelaceae merupakan tanaman yang tumbuh di kawasan Indonesia. Tanaman ini banyak dimanfaatkan dalam membantu pengobatan berbagai jenis penyakit termasuk penyakit ringan hingga penyakit ganas. Perlu dilakukan uji fitokimia pada tanaman obat, uji fitokimia mengacu pada kandungan senyawa metabolit sekunder pada suatu tumbuhan yang memiliki manfaat bagi kesehatan atau berperan aktif dalam mencegah penyakit. Berdasarkan strukturnya bahan kimianya, senyawa metabolit sekunder dibagi menjadi beberapa yakni, alkaloid, steroid, flavonoid, tanin, saponin, terpenoid, dan antrakuinon. Kebaruan dalam penelitian ini yaitu meneliti tentang ekstrak akar batang daun buah biji mahkota dewa. Penelitian ini bertujuan untuk mengidentifikasi kandungan senyawa metabolit sekunder secara kuantitatif pada akar, batang, daun, buah dan biji mahkota dewa (phaleria macrocarpa). Pada penelitian ini digunakan jenis penelitian deskriptif dengan metode kualitatif dan kuantitatif untuk menguji kandungan senyawa metabolit sekunder dan mengidentifikasi kadar flavonoid total pada ekstrak Mahkota Dewa. Hasil penelitian ini ditemukan bahwa hanya buah mahkota dewa yang mengandung senyawa fenol, flavonoid, alkaloid, saponin, terpenoid dan tanin. Sedangkan pada akar, batang daun dan biji mahkota dewa terdapat senyawa fenol, flavonoid, alkaloid, trapenoid, tanin dan tidak mengandung saponin. Kadar total flavonoid pada akar 11,8557, batang 0,7371, daun 12,2478, buah 21,5948, dan biji 30,9057 yang dinyatakan sebagai milligram ekivalen kuersetin tiap 1 gram berat ekstrak (mg QE/g ekstrak). Kesimpulan terdapat berbagai kandungan senyawa metabolit sekunder dan kadar total flavonoid yang berbeda pada ekstrak akar, batang, daun, buah dan biji mahkota dewa.Kata kunci: Mahkota Dewa (Phaleria Macrocarpa); Metabolit Sekunder; Uji Fitokimia.AbstractPhalera macrocarpa from the Thymelaceae family is a plant that grows in Indonesia. This plant is widely used in helping the treatment of various diseases, including minor diseases to malignant diseases. It is necessary to carry out phytochemical tests on medicinal plants; phytochemical tests refer to secondary metabolite compounds found in a plant that have health benefits or play an active role in preventing disease. Based on their chemical structure, secondary metabolites are divided into several groups, namely, alkaloids, flavonoids, steroids, tannins, saponins, terpenoids, and anthraquinones. The novelty of this study is to examine the root extract of the leaves of the crown of the gods. This study aims to identify the content of secondary metabolites quantitatively in the roots, stems, leaves, fruits, and seeds of the god crown (phaleria macrocarpa). This research used descriptive research with qualitative and quantitative methods to test the content of secondary metabolites and identify total flavonoid levels in Phaleria macrocarpa extract. The results of this study found that only Mahkota Dewa fruit contained phenolic compounds, flavonoids, alkaloids, saponins, terpenoids and tannins. Meanwhile, the roots, stems, leaves, and seeds of Phaleria macrocarpa contain phenolic compounds, flavonoids, alkaloids, terpenoids, tannins and do not contain saponins. Total levels of flavonoids in roots 11.8557, stems 0.7371, leaves 12.2478, fruit 21.5948, and seeds 30.9057 expressed as milligrams of quercetin equivalent per 1 gram of extract weight (mg QE/g extract). The conclusion is that there are various contents of secondary metabolites and different levels of total flavonoids in the extracts of the roots, stems, leaves, fruits, and seeds of Phaleria macrocarpa.Keywords: Phaleria Macrocarpa; Secondary metabolite; Photochemical Test.
Environment and Mental's Health in The Pandemic Time Covid-19 in IGD Nurse Royal Prima Medan Hospital Khainir Akbar; Sri Lestari Ramadhani Nasution; Ermi Girsang
Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan Vol 15, No 1 (2021): Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran UPN Veteran Jakarta Kerja Sama KNPT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jpm.v15i1.2772

Abstract

The mental health of health workers during the COVID-19 pandemic period is a present issue that must be given more attention. It is because health workers are the spearhead of handling the COVID19 case, which is daily increasing. The purpose of the research to examine the mental health of IGD nurses at Royal Prima Hospital Medan by using variable demographic characteristics (age, gender, years of service), family environment, social environment, and work environment. This type of research is a quantitative study, with the research sample being all emergency room nurses at Royal Prima Hospital Medan. The data were processed using correlation analysis in SPSS. The results showed that the demographic characteristics, family environment, social environment, and work environment were positively correlated with mental health in IGD nurses at Royal Prima Medan Hospital. Suggestions for further research are to use a larger sample and be able to use other variables according to the theory of Cooper and Davidson
The In Vitro Anti-Diabetic Activity of Lime Peels (Citrus amblycarpa (Hassk.) Ochse) Gempita cahya aulia tambunan; Aparna dutt; sayra nadhifa; firdha amelia; ermi girsang
Jurnal Ilmiah Kesehatan Vol 13 No 01 (2020): Jurnal Ilmiah Kesehatan (Journal of Health Science)
Publisher : Universitas Nahdlatul Ulama Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (500.438 KB) | DOI: 10.33086/jhs.v13i01.1437

Abstract

There are various potential natural anti-diabetic drugs; one of them is lime peel or Citrus amblycarpa. This study was aimed to explore the anti-diabetic activity and phytochemical content of lime peels. This study was an experimental study that used the post-test only control group design. The lime peels that were collected from the Berastagi fruit market in Medan, North Sumatera were extracted using 70% ethanol by maceration methods. The phytochemical screening identified the presence of phenolic, steroid/triterpenoid, terpenoid, saponin, flavonoid, tannin, and alkaloid. Meanwhile, the anti-diabetic activity of lime peels was evaluate using the α-glucosidase enzyme that was gotten from Saccharomyces cerevisiae by α-glucosidase enzyme inhibition methods. Percent of inhibition was express as Mean ± SD and analyzed by One Way ANOVA, Tukey HSD Post Hoc Test, and followed by linear regression. The result of this study showed that there is a significant difference in percentage inhibition α-glucosidase enzyme in each concentration, and it had an IC50 Value amount of 125.93 ± 9.14 µg/mL. The phytochemical content of the lime peels was flavonoid, phenol, steroid/triterpenoid, and alkaloid. Hence, the lime peel has anti-diabetic activity by inhibition of the α-glucosidase enzyme.
Co-Authors Ahmad Affandi Ahmad Raif Albert Albert Aldi Tambunan Ali Nafiah Nasution Ali Napiah Aparna dutt Axel Valerian Ayu Anggraini Bangun Batara Sanjaya Harahap Cendy Juliana Chandra Susanto Chrismis Novalinda Ginting Christine Yennyanti Cindy Stefanie Sinaga Cory Oriensia Siahaan Dewi Dio Damara Handoyo Dwi Apriany Edy Fachrial Efratiwi Marpaung Eka Lolita Pakpahan Elsi Rahmini Eprina Intami Erna Dame Juliyanti Sihombing Ervineco Limestan Evelyn Angie Fadillah, Qori Febby Maulina firdha amelia Fithri Ananda Frans Judea Samosir Friska SR Gempita cahya aulia tambunan Hafiz Hawari Siregar Hartono Hartono I Nyoman Ehrich Lister I. Nyoman Ehrich Lister IKHTIARI, REFI Imelda Lingga Ira Gracela Jeri Yuliansyah Jerry Fidelio Susanto Johannes Bastira Ginting Juli Elisabet Mayen br Meliala Khainir Akbar Landi Kurnia Daeli Liena Linda Chiuman Maco Chan Adnan Mangatas Silaen Masryna Siagian Megasilvia Sinaga Muhammad Maulidin Muhammad Rinaldy Muliate Tarigan Nadya Nazimuddin Putri Nasution, Ali Napiah Nasution, Sri Lestari Ramadhani Nurul Apla Wizaya Syahputri Putranto Manalu Randa Aqila Lubis Rapael Ginting Rapael Ginting Riri Virzan Putri Robertus Idealistis Bago Santy Deasy Siregar Saud Parulian Harianja sayra nadhifa Sri Lestari Rahamdhani Nasution Sri Lestari Ramadhani Nasution Sri Rezeki Susi Susanti Tan Suyono Tiara Nabila Nabati Wahyu Widowati Widiya Nisa Yogie Chandra