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All Journal e-CliniC JURNAL BIOMEDIK Medical Scope Journal (MSJ)
Agnes L. Panda
Universitas Sam Ratulangi Manado
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Nursing Public Health

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Journal : Medical Scope Journal (MSJ)

 1 
Hubungan Rasio Trigliserida/High Density Lipoprotein-Cholesterol (TG/HDL-C) dengan Kejadian Infark Miokard Akut di RSUP Prof. Dr. R. D. Kandou Manado Alia, Jaka K.; Jim, Edmond L.; Panda, Agnes L.
Medical Scope Journal Vol 1, No 2 (2020): Medical Scope Journal
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/msj.1.2.2020.27460

Abstract

Abstract: Acute myocardial infarction (AMI) is caused by sudden disturbance of oxygen need and supply to the heart, affected by atheroma rupture that results in thrombocyte aggregation, thrombus formation, and coronary spasm that clogs the coronary artery. Patients that make it after a myocardial infarction have an increased risk of recurring infarctions with a yearly death number of 5%, six times higher than people of the same age without coronary artery disease. This study was aimed to determine the correlation between triglyceride/high density lipoprotein-cholesterol and AMI incidence at Prof. Dr. R. D. Kandou Hospital, Manado. This was an analytical and observational study with a cross sectional and retrospective approaches. This study showed that mean TG/HDL-C ratio was higher in subjects with AMI than in subjects without AMI. The Pearson correlation test showed a p-value of 0.553 for the correlation between mean TG/HDL-C ratio and AMI incidence. In conclusion, there was no reltionship between mean TG/HDL-C ratio and acute myocardial infarction incidence.Keywords: TG/HDL-C ratio, acute myocardial infarction, dyslipidemia Abstrak: Infark miokard akut (IMA) disebabkan oleh gangguan kebutuhan dan pasokan oksigen ke jantung secara mendadak disebabkan oleh ruptur ateroma yang berlanjut dengan agregasi trombosit, terbentuknya trombus, dan spasme koroner sehingga menyumbat arteri koroner. Pasien yang selamat dari infark miokard mengalami peningkatan risiko infark berulang dan memiliki tingkat kematian tahunan 5%, enam kali lipat pada orang dengan usia yang sama dan tidak menderita penyakit jantung koroner. Penelitian ini bertujuan untuk mengetahui hubungan rasio trigliserida/kolesterol-HDL dengan kejadian infark miokard akut di RSUP Prof. Dr. R. D. Kandou Manado. Jenis penelitian ialah analitik observasional dengan desain potong lintang. Hasil penelitian mendapatkan bahwa rerata kadar rasio TG/HDL-C lebih tinggi pada subjek yang menderita IMA dibandingkan subjek non-IMA. Hasil uji korelasi Pearson terhadap hubungan antara rasio TG/HDL-C dengan kejadian IMA mendapatkan nilai p=0,553. Simpulan penelitian ini ialah tidak terdapat hubungan antara rasio TG/HDL-C dengan kejadian infark miokard akut.Kata kunci: rasio TG/HDL-C, infark miokard akut, dislipidemia
Gambaran Fungsi Ginjal Pasien PJK dengan Oklusi Total Kronik yang Menjalani IKP di RSUP Prof. Dr. R. D. Kandou Manado Periode Januari-Desember 2022 Anjani, Ni Made; Panda, Agnes L.; Jim, Edmond L.
Medical Scope Journal Vol. 7 No. 1 (2025): Medical Scope Journal
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/msj.v7i1.54929

Abstract

Abstract: Accumulation of fat on the walls of blood vessels can affect blood flow to the heart muscles which has an impact on heart and kidney functions. This study aimed to obtain the description of kidney function in patients with coronary artery disease (CAD) with chronic total occlusion (CTO) who underwent percutaneous coronary intervention (PCI). This was a retrospective and descriptive study with a cross-sectional design. Samples were CAD patients with CTO registered in medical records of Prof. Dr. R. D. Kandou Hospital from January to December 2022. The results showed that there were 95 cases of CTO who underwent PCI. There were 36 (37.9%) patients with increased creatinine levels and decreased eGFR including 33 (34.7%) males, 20 (43.5%) aged 45-59 years, seven (7.4%) with hypertension. There were six patients (16.7%) with contrast induced nephropathy (CIN) including five (13.9%) males, three (8.3%) aged ≥70 years, and two (5.6%) with dyslipidemia. In conclusion, elevated creatinine levels and decreased eGFR are more common in males, pre-elderly, and with hypertension, meanwhile contrast induced nephropathy is more common in males, high-risk elderly, and with dyslipidemia as comorbid. Keywords: kidney function; coronary heart disease; chronic total occlusion; percutaneous coronary intervention   Abstrak: Penumpukan lemak pada dinding pembuluh darah dapat memengaruhi aliran darah ke otot jantung yang berdampak pada fungsi jantung dan ginjal. Penelitian ini bertujuan untuk mengetahui gambaran fungsi ginjal pasien penyakit jantung coroner (PJK) dengan oklusi total kronik (OTK) yang menjalani intervensi koroner perkutan (IKP). Jenis penelitian ialah deskriptif retrospektif dengan desain potong lintang. Sampel penelitian ialah pasien PJK dengan OTK yang tercatat di Rekam Medik RSUP Prof. Dr. R. D. Kandou Manado periode Januari-Desember 2022. Hasil penelitian mendapatkan 95 kasus OTK yang menjalani IKP. Terdapat 36 (37,9%) mengalami peningkatan kadar kreatinin dan penurunan eGFR di antaranya 33 (34,7%) laki-laki, 20 (43,5%) berusia 45-59 tahun, tujuh (7,4%) dengan hipertensi. Terdapat enam pasien (16,7%) yang mengalami contrast induced nephropathy (CIN) diantaranya lima (13,9%) laki-laki, tiga (8,3%) berusia ≥70 tahun, dan dua (5,6%) dengan dislipidemia. Simpulan penelitian ini ialah peningkatan kadar kreatinin dan penurunan eGFR sering terjadi pada laki-laki, kelompok pra lanjut, dengan hipertensi sedangkan contrast induced nephropathy sering terjadi pada pasien laki-laki, usia lanjut berisiko tinggi dan penyakit penyerta dislipidemia. Kata kunci: fungsi ginjal; penyakit jantung koroner; oklusi total kronik; intervensi koroner perkutan
Pengaruh Rehabilitasi Kardiovaskular terhadap Kapasitas Fisik pada Pasien Gagal Jantung Santoso, Richard L.; Joseph, Victor F. F.; Panda, Agnes L.
Medical Scope Journal Vol. 7 No. 2 (2025): Medical Scope Journal
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/msj.v7i2.60821

Abstract

Abstract: Cardiovascular rehabilitation is one of the essential management strategies recommended to enhance functional capacity of patients with heart failure. This study aimed to determine the effect of cardiovascular rehabilitation on physical capacity in heart failure patients at Prof. Dr. R. D. Kandou Hospital Manado. This was a descriptive and analytical method with a retrospective and cross-sectional design. This study involved 145 heart failure patients undergoing cardiovascular rehabilitation, of whom 48 fulfilled the inclusion criteria, while 97 were excluded. The results showed that majority of participants were male, aged 45–59 years, and had a body mass index (BMI) in the obesity I category. Most patients had hypertension, dyslipidaemia, and were prescribed ACE-I/ARB and statin therapies. Most participants' ejection fractions were classified as reduced (<40%) or mildly reduced (40–49%). Statistical analysis using the paired t-test showed significant improvements in 6-minute walk test distance, VO2 Max, and METs after cardiovascular rehabilitation (p-value <0.05 for each variable). In conclusion, cardiovascular rehabilitation significantly improved physical capacity in heart failure patients, as evidenced by increased 6-minute walk test distance, VO2 Max, and METs. These findings indicate a positive effect of cardiovascular rehabilitation on the physical capacity of heart failure patients at Prof. Dr. R. D. Kandou Hospital Manado. Keywords: cardiovascular rehabilitation; physical capacity; heart failure   Abstrak:Rehabilitasi kardiovaskular merupakan salah satu strategi penatalaksanaan penting yang direkomendasikan untuk meningkatkan kapasitas fungsional pasien gagal jantung. Penelitian ini bertujuan untuk menganalisis pengaruh rehabilitasi kardiovaskular terhadap kapasitas fisik pada pasien gagal jantung di RSUP Prof. Dr. R. D. Kandou Manado. Jenis penelitian ialah deskriptif analitik dengan desain potong lintang retrospektif. Sampel penelitian ialah 145 pasien gagal jantung yang menjalani rehabilitasi kardiovaskular; 48 pasien memenuhi kriteria inklusi dan 97 pasien dieksklusi. Hasil penelitian mendapatkan mayoritas pasien ialah laki-laki, berusia 45–59 tahun, dengan indeks massa tubuh (IMT) kategori obesitas I. Sebagian besar pasien memiliki hipertensi, dislipidemia, dan mendapatkan terapi ACE-I/ARB serta statin. Sebagian besar fraksi ejeksi pasien dikategorikan sebagai reduced ejection fraction (<40%) atau mildly reduced ejection fraction (40–49%). Analisis statistik menggunakan uji paired t-test menunjukkan peningkatan bermakna pada jarak tempuh uji jalan 6 menit, VO2 Max, dan METs setelah rehabilitasi kardiovaskular (nilai p<0,05 untuk setiap variabel). Simpulan penelitian ini ialah rehabilitasi kardiovaskular secara bermakna meningkatkan kapasitas fisik pasien gagal jantung, yang ditunjukkan oleh peningkatan jarak tempuh uji jalan 6 menit, VO2 Max, dan METs. Temuan ini mengindikasikan adanya pengaruh positif rehabilitasi kardiovaskular terhadap kapasitas fisik pasien gagal jantung di RSUP Prof. Dr. R. D. Kandou Manado. Kata kunci: rehabilitasi kardiovaskular; kapasitas fisik; gagal jantung
Co-Authors Aaron Ch. Rambi Alia, Jaka K. Anjani, Ni Made Christin Tatukude, Christin Desire Sutrisno Dewanti, Lidia A. D. Dewi U. Djafar, Dewi U. Edmond L. Jim Elfan Moeljono Emor, Engelin E. Fitri Jumalang Fonny M. Tedjo Ike Adriana, Ike Iman Y. Suhartono Ira Posangi Jacqueline A. Fuzairi, Jacqueline A. Jan H. Awaloei Janry A. Pangemanan Janry Pangemanan Jeffrey Ongkowijaya Linda W. A. Rotty Loretta C. Wangko Masola, Adhytia B. C. P. Michael S. Kawilarang Monique Rotty, Monique Parera, Ferdinand I. Polii, Natalia C. I. Polii, Natalia Ch. Reginald L. Lefrandt Ronaldi ., Ronaldi Santoso, Richard L. Setiono, Richella M. W. Sihombing, David H. P. Sitepu, Ade M. Starry H. Rampengan Tambuwun, Christa F.D. Terrance Ransun Tumbel, Mawarni I.S. Ventje Kawengian Victor F. F. Joseph, Victor F. F. Wagiu, Mutiara B. Wenas, Mercilia F.