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FORMULASI GEL ANTIOKSIDAN EKSTRAK KULIT BUAH MANGGIS (Garcinia mangostana L) dengan BASIS CARBOPOL Supomo Supomo; Sapri Sapri; Nur Komalasari
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 1 No 1 (2016): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1344.787 KB) | DOI: 10.36387/jiis.v1i1.29

Abstract

            Pada masa kini perawatan kulit sangat diperlukan untuk melindungi kulit dari efek oksidatif radikal bebas yaitu dengan menggunakan antioksidan. Kulit buah manggis (Garcinia mangostana L.) mengandung xanton yang merupakan antioksidan yang sangat kuat. Antioksidan merupakan zat yang dapat menetralkan radikal bebas sehingga dapat melindungi sistem biologi tubuh dari efek merugikan yang timbul dari proses ataupun reaksi yang menyebabkan oksidasi yang berlebihan. Tujuan penelitian ini adalah memformulasikan ekstrak kulit buah manggis dengan konsentrasi tertentu dalam bentuk sediaan gel antioksidan dan mengetahui sifat fisik dan kimianya.            Penelitian yang dilakukan adalah penelitian eksperimental. Obyek yang diteliti adalah ekstrak kulit buah manggis (Garcinia mangostana L.) yang diekstrasi menggunakan cara maserasi. Formula dibuat dengan mevariasikan 3 konsentrasi ekstrak etanol kulit buah manggis 0,2%, 0,4%, dan 0,6% menggunakan gelling agent karbopol 940 0,5%. Pengujian sediaan gel dilakukan terhadap organoleptis (bau, warna, tekstur), homogenitas, pH, iritasi kulit, dan daya sebar gel antioksidan.            Hasil pengujian sifat fisik, gel ekstrak etanol kulit buah manggis menggunakan basis karbopol 940  pada formula I dengan konsentrasi ekstrak 0,2% berwarna kuning keputihan, formula II dengan konsentrasi 0,4% berwarna kuning coklat muda, formula III dengan konsentrasi 0,6% berwarna kuning coklat tua dan masing-masing formula berbau oleum citri dan bertekstur kental halus, memiliki nilai pH 6 dengan homogenitas yang baik dan tidak mengiritasi. Daya sebar yang dihasilkan pada masing-masing formula gel antioksidan memiliki nilai yang tidak memenuhi persyaratan daya sebar.             Dari penelitian ini dapat disimpulkan bahwa ekstrak etanol kulit buah manggis (Garcinia mangostana L.) dapat diformulasikan sebagai gel antioksidan. Formula gel antioksidan yang terbaik yaitu pada formula I dengan konsentrasi ektrak 0,2% dengan hasil pengujian sifat fisik yang cukup stabil serta memiliki warna yang lebih transparan. Kata Kunci : Buah manggis (Garcinia mangostana L), Antioksidan, Gel
FORMULASI GELHAND SANITIZER DARI KITOSAN DENGAN BASIS NATRIUM KARBOKSIMETILSELULOSA Supomo Supomo; Yullia Sukawati; Fredi Basyar
Jurnal Ilmiah Manuntung Vol 1 No 1 (2015): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v1i1.8

Abstract

Chitosan has been widely used in industrial, food, pharmaceuticals and agriculture. Chitosan is a natural biocompatible polymers means that as nature does not have the side effect, non-toxic, can not be easily digested and broken down by microbes (biodegradable). This study aims to determine whether the chitosan may be formulated into dosage gel hand sanitizer that meets the requirements of the physical stability of the gel.Chitosan is formulated with 3 varying concentrations of Na CMC basis of 3%, 4.5% and 6%. Tests conducted gel formulation is the physical stability test which includes organoleptic test, homogeneity, pH test, test dispersive power, viscosity test and test consistency. Testing is done every week for 4 weeks of storage.Results of testing physical properties of chitosan gel hand sanitizer has the shape and color stable but the resulting aroma change during storage. pH gel meet the requirements, the consistency test of phase separation does not occur, the homogeneity test showed no homogeneous gel, gel dispersive power does not meet the requirements, the viscosity of the gel preparation third formula does not meet the requirements of viscosity gel
UJI TOKSISITAS AKUT EKSTRAK ETANOL DAUN KEREHAU (Callicarpa longifolia Lam.) TERHADAP MENCIT PUTIH Eka Siswanto; Desy Nur Indah Sari; Supomo Supomo
Jurnal Ilmiah Manuntung Vol 1 No 2 (2015): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v1i2.24

Abstract

Leaves kerehau (Callicarpa longifolia Lam.) is one of the plants used for the treatment of malaria, ulcers, diarrhea, treatment after delivery, and fever, by drinking boiled water. Report usage and security kerehau leaves are still very few. The purpose of this study to determine the potential for acute toxicity by determining the value of LD50 (Lethal Dose 50) in 4 dose-rise that dose I, II, III, and IV of the ethanol extract of the leaves kerehau against this mice. The Research. Pharmacologically using experimental methods using a completely randomized design pattern is undirectional in the selection of test animals, They are 25 mice were divided into five groups (5 mice each group), with observed 4 hours to determine the toxic symptoms and continued observation every 24 hours for 7 days to see death. Results from this study show from 4 dose levels, dose group I = 16g / kg, group II = 8g / kg, group III = 4g / kg and group IV = 2g / kg and control = 0.5 ml Na-CMC. Symptoms namely the observation of behavior and neuromuscular but not on observations of the autonomic nervous, respiratory, gastrointestinal, and skin. LD50 value obtained is expressed by the LD50 (16g / kg) were categorized as practically non-toxic (> 15g / kg)
PEMANFAATAN EKSTRAK HERBAL TERHADAP PRODUKTIVITAS DAN MUTU AYAM PEDAGING SEBAGAI UPAYA KETAHANAN PANGAN DI KALIMANTAN TIMUR BERBASIS PETERNAKAN RAMAH LINGKUNGAN Supomo Supomo; Eka Siswanto; Ine Ventyrina
Jurnal Ilmiah Manuntung Vol 2 No 1 (2016): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v2i1.52

Abstract

Quality broilers become a serious problem for farmers. Many studies done to solve these problems, one of them by making use of natural materials. Some plants are known to have the ability to improve the quality of broilers as bitter, ginger and onions tiwai. This study aimed to determine the effect of ethanol extract of the herb on the quality of broilers. Subjects used is Strain Cobb broiler DOC. A total of 60 chickens were kept in a cage stage measuring 1.5 x 1.5 m for 30 days. Subjects were divided into five treatment where each treatment consisted of four tails. The experiment was conducted with three replications using a completely randomized design. Such treatment includes control (P0), the ethanol extract of sambiloto 0.02 % (P1), the ethanol extract of umbi bawang dayak 0.05 % (P2), the ethanol extract of temulawak 0,075 (P3), Product Imugas (P4). Quality parameters include coarse fat content and crude protein. The data obtained were statistically analyzed using analysis of variance (ANOVA). The results showed that the treatment of all types of ethanol extract of the herb can improve the quality of broilers compared to control (sig < 0.05), the type of treatment is best to P4. Quality parameters which include : crude protein and crude lipid. Levels of the protein, which is the highest in treatment P4 by 23.87% . Fat content, which is the lowest in treatment P4 of 10.50%
Co-Authors Desy Nur Indah Sari Eka Siswanto Fredi Basyar Ine Ventyrina Nur Komalasari Sapri Sapri Yullia Sukawati