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All Journal Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Eka Siswanto
Akademi Farmasi Samarinda
Chemistry Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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UJI AKTIVITAS ANTIINFLAMASI FRAKSI AIR EKSTRAK DAUN SELEDRI (Apium graveolens L.) PADA MENCIT JANTAN Sapri Sapri; Eka Siswanto; Ariska Yulianti
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 2 No 1 (2017): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (344.001 KB) | DOI: 10.36387/jiis.v2i1.82

Abstract

Tanaman seledri (Apium graveolens L.) memiliki potensi untuk dikembangkan menjadi obat antiinflamasi karena kandungan senyawa glikosida flavonoid yaitu apiin sehingga digunakan fraksi air karena lebih mudah tertarik pada fraksi air. Penelitian ini bertujuan untuk mengetahui aktivitas fraksi air ekstrak daun seledri sebagai antiinflamasi pada mencit putih dengan  menggunakan metode induksi karagenan pada telapak kaki serta mengetahui nilai ED50. Pengukuran aktivitas antiinflamasi digunakan 5 kelompok perlakuan hewan uji, kontrol (+) digunakan kalium diklofenak 50 mg, kontrol (-) suspensi Na. CMC 0,5%, dosis I adalah 125mg/kgBB, dosis II adalah 250mg/kgBB dan dosis III adalah 500mg/kgBB. Dengan pengukuran setiap 30 menit selama 5 jam dengan alat pletismometer. Analisis data digunakan metode statistik One way ANOVAdengan tingkat kepercayaan 95% yang dilanjutkan dengan uji LSD. Hasil penelitian menunjukkan bahwa ketiga dosis fraksi air ekstrak daun seledri memiliki aktivitas antiinflamasi. Pada menit ke-300 tidak terjadi perbedaan bermakna antara kontrol positif dengan dosis 500 mg/kgBB dengan persen inhibisi 86,04%. Dari perhitungan ED50 didapatkan hasil sebesar 100 mg/kgBB.
UJI TOKSISITAS AKUT EKSTRAK ETANOL DAUN KEREHAU (Callicarpa longifolia Lam.) TERHADAP MENCIT PUTIH Eka Siswanto; Desy Nur Indah Sari; Supomo Supomo
Jurnal Ilmiah Manuntung Vol 1 No 2 (2015): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v1i2.24

Abstract

Leaves kerehau (Callicarpa longifolia Lam.) is one of the plants used for the treatment of malaria, ulcers, diarrhea, treatment after delivery, and fever, by drinking boiled water. Report usage and security kerehau leaves are still very few. The purpose of this study to determine the potential for acute toxicity by determining the value of LD50 (Lethal Dose 50) in 4 dose-rise that dose I, II, III, and IV of the ethanol extract of the leaves kerehau against this mice. The Research. Pharmacologically using experimental methods using a completely randomized design pattern is undirectional in the selection of test animals, They are 25 mice were divided into five groups (5 mice each group), with observed 4 hours to determine the toxic symptoms and continued observation every 24 hours for 7 days to see death. Results from this study show from 4 dose levels, dose group I = 16g / kg, group II = 8g / kg, group III = 4g / kg and group IV = 2g / kg and control = 0.5 ml Na-CMC. Symptoms namely the observation of behavior and neuromuscular but not on observations of the autonomic nervous, respiratory, gastrointestinal, and skin. LD50 value obtained is expressed by the LD50 (16g / kg) were categorized as practically non-toxic (> 15g / kg)
UJI AKTIVITAS EKSTRAK ETANOL GAMBIR (Uncaria gambir Roxb.) TERHADAP PENYEMBUHAN LUKA BAKAR PADA KULIT PUNGGUNG MENCIT PUTIH JANTAN (Mus musculus) Fitri Handayani; Eka Siswanto; Lintang Ayu Trisna Pangesti
Jurnal Ilmiah Manuntung Vol 1 No 2 (2015): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v1i2.25

Abstract

Gambir (Uncaria gambir Roxb.) contains flavonoids, tannins, saponins and alkaloids that can help in the healing process of burns on the back skin of mice. Gambir has been used for the treatment because it has the effect of antimicrobial and anti-inflammatory. Gambir is used by the people as a traditional medicine to treat burns.This research is experimental research. The object studied is the potential of gambir extract on healing burns of mice back skin. The number of mice used are 15 which divided into 5 groups: the positive control group (branded ointment), negative control group (vaseline flavum), group of gambir ethanol extract and vaseline flavum concentration of 25%, 35%, and 45%. Each group consisted of 3 mice.Backs of the mice induced using a heated solder which tip contained stainlees plate measuring 1x1 cm and placed for 2 seconds on the back skin of mice. The percentage of burns healing is obtained by calculating the surface area of the wound. The data were analyzed using ANOVA analysis followed by LSD test. The results showed that ethanol extract of gambir concentration of 25% with the healing burns percentage of (72.00%), the concentration of 35% (85.00%), and the concentration of 45% (88.67%) have activity on healing burns of back skin of mice. The results of data analysis using ANOVA showed that the data has significant differences with a significance value <0.05 is 0.000. LSD test results stated that each treatment group have significant differences with a significance value <0.05. It can be seen that with increasing dose will be followed by duration of burns healing
PEMANFAATAN EKSTRAK HERBAL TERHADAP PRODUKTIVITAS DAN MUTU AYAM PEDAGING SEBAGAI UPAYA KETAHANAN PANGAN DI KALIMANTAN TIMUR BERBASIS PETERNAKAN RAMAH LINGKUNGAN Supomo Supomo; Eka Siswanto; Ine Ventyrina
Jurnal Ilmiah Manuntung Vol 2 No 1 (2016): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v2i1.52

Abstract

Quality broilers become a serious problem for farmers. Many studies done to solve these problems, one of them by making use of natural materials. Some plants are known to have the ability to improve the quality of broilers as bitter, ginger and onions tiwai. This study aimed to determine the effect of ethanol extract of the herb on the quality of broilers. Subjects used is Strain Cobb broiler DOC. A total of 60 chickens were kept in a cage stage measuring 1.5 x 1.5 m for 30 days. Subjects were divided into five treatment where each treatment consisted of four tails. The experiment was conducted with three replications using a completely randomized design. Such treatment includes control (P0), the ethanol extract of sambiloto 0.02 % (P1), the ethanol extract of umbi bawang dayak 0.05 % (P2), the ethanol extract of temulawak 0,075 (P3), Product Imugas (P4). Quality parameters include coarse fat content and crude protein. The data obtained were statistically analyzed using analysis of variance (ANOVA). The results showed that the treatment of all types of ethanol extract of the herb can improve the quality of broilers compared to control (sig < 0.05), the type of treatment is best to P4. Quality parameters which include : crude protein and crude lipid. Levels of the protein, which is the highest in treatment P4 by 23.87% . Fat content, which is the lowest in treatment P4 of 10.50%
Co-Authors Ariska Yulianti Desy Nur Indah Sari Fitri Handayani Ine Ventyrina Lintang Ayu Trisna Pangesti Sapri Sapri Supomo Supomo