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All Journal Biotropika Jurnal Teknologi Laboratorium MATAPPA: Jurnal Pengabdian Kepada Masyarakat
Sofy Permana
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Education Immunology & microbiology Other

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Potensi Fraksi Etanol Benalu Mangga (Dendrophthoe pentandra) sebagai Agen Anti Kanker Kolon pada Mencit (Mus musculus Balb/c) setelah Induksi Dextran Sulvat (DSS) danAzoxymethane (AOM) Baramada Wicaksono, Moch Hardi; Permana, Sofy
Biotropika: Journal of Tropical Biology Vol 1, No 2 (2013)
Publisher : Biotropika: Journal of Tropical Biology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (217.324 KB)

Abstract

ABSTRAK Penelitian ini bertujuan untuk mengetahui kemampuan Dendrophthoe pentandra dalam memperbaiki perubahan jaringan akibat kanker kolon. Fraksi etanol benalu manga diberikan pada tiga kelompok mencit dengan dosis 0,125 mg/gram BB, 0,250 mg/gram BB dan 0,500 mg/gram BB yang sudah diinduksi kanker kolon dengan 10 mg/kg AOM dan 5 % DSS dan setelah 11 minggu organ kolon diisolasi dan dibuat preparat jaringan dengan metode parafin H&E. Parameter yang diamati meliputi jumlah sel goblet dan abnormalitas struktur jaringan (dysplasia). Data diuji secara statistik menggunakan uji normalitas dan uji homogenitas.Hasil penelitian menunjukan terjadi perbaikan sel goblet pada perlakuan dosis fraksi etanol benalu mangga 0,500 mg/gram BB.Fraksi etanol benalu mangga mampu memperbaiki abnormalitas jaringan kolon yang ditunjukkan dengan tidak terjadinya dysplasia pada perlakuan fraksi etanol benalu mangga 0,250 mg/gram BB dan 0,500 mg/gram BB.Benalu mangga berpotensi sebagai agen anti kanker kolon. .Kata kunci :AOM, benalu mangga, DSS, kanker kolon,nitrotyrosine, sel goblet
Conserved B-cell epitope identification of envelope glycoprotein (GP120) HIV-1 to develop multi-strain vaccine candidate through bioinformatics approach Kharisma, Viol Dhea; Ansori, Arif Nur Muhammad; Posa, Gabrielle Ann Villar; Rizky, Wahyu Choirur; Permana, Sofy; Parikesit, Arli Aditya
Jurnal Teknologi Laboratorium Vol 10 No 1 (2021): inpress
Publisher : POLTEKKES KEMENKES YOGYAKARTA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29238/teknolabjournal.v10i1.274

Abstract

Acquired immune deficiency syndrome (AIDS) has been identified from US patients since 1981. AIDS is caused by infection with the human immunodeficiency virus type 1 (HIV-1) which is a retrovirus. HIV-1 gp120 can be recognized by the immune system because it is located outside the virion. The conserved region is identified in gp120, and it is recognized by an immune cell which then initiates specific immune responses, viral mutation escape, and increase vaccine protection coverage, a benefit derived from the conserved region-based vaccine design. However, previous researchers have little knowledge on this conserved region as a target for vaccine design. This paper explains how the conserved region of gp120 HIV-1 is a major target for vaccine design through a bioinformatics approach. The conserved region from gp120 was explored as a vaccine design target with a bioinformatics tool that consists of B-cell epitope mapping, vaccine properties, molecular docking, and dynamic simulation. The peptide vaccine candidate of B5 with the gp120 HIV-1 conserved region was found to provoke B-cell activation through a direct pathway, produce specific antibody, and increase protection from multi-strain viral infection.
Potensi Fraksi Etanol Benalu Mangga (Dendrophthoe pentandra) sebagai Agen Anti Kanker Kolon pada Mencit (Mus musculus Balb/c) setelah Induksi Dextran Sulvat (DSS) danAzoxymethane (AOM) Moch Hardi Baramada Wicaksono; Sofy Permana
Biotropika: Journal of Tropical Biology Vol 1, No 2 (2013)
Publisher : University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

ABSTRAK Penelitian ini bertujuan untuk mengetahui kemampuan Dendrophthoe pentandra dalam memperbaiki perubahan jaringan akibat kanker kolon. Fraksi etanol benalu manga diberikan pada tiga kelompok mencit dengan dosis 0,125 mg/gram BB, 0,250 mg/gram BB dan 0,500 mg/gram BB yang sudah diinduksi kanker kolon dengan 10 mg/kg AOM dan 5 % DSS dan setelah 11 minggu organ kolon diisolasi dan dibuat preparat jaringan dengan metode parafin H&E. Parameter yang diamati meliputi jumlah sel goblet dan abnormalitas struktur jaringan (dysplasia). Data diuji secara statistik menggunakan uji normalitas dan uji homogenitas.Hasil penelitian menunjukan terjadi perbaikan sel goblet pada perlakuan dosis fraksi etanol benalu mangga 0,500 mg/gram BB.Fraksi etanol benalu mangga mampu memperbaiki abnormalitas jaringan kolon yang ditunjukkan dengan tidak terjadinya dysplasia pada perlakuan fraksi etanol benalu mangga 0,250 mg/gram BB dan 0,500 mg/gram BB.Benalu mangga berpotensi sebagai agen anti kanker kolon. .Kata kunci :AOM, benalu mangga, DSS, kanker kolon,nitrotyrosine, sel goblet
Pelatihan Uji Fisik dan Cita Rasa Kopi Sebagai Instrumen Kontrol Kualitas Kopi dalam Menunjang Wisata Kopi bagi Masyarakat Luchman Hakim; Sofy Permana; Jati Batoro; Brian Rahardi; Riyan Riyadlun Najih
MATAPPA: Jurnal Pengabdian Kepada Masyarakat Volume 6 Nomor 3 Tahun 2023
Publisher : STKIP Andi Matappa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31100/matappa.v6i3.3147

Abstract

Increasing coffee farmer capacity to produce good coffee bean standar was important. The objective of community service activities were to (1) increase community knowledge about coffee trade prospects and the need for quality coffee, (2) increase community understanding of good coffee farming practices to produce quality coffee beans and (3) increase community understanding of how to recognize coffee bean quality based on basic organoleptic tests. Increasing farmers' knowledge and capacity in coffee production can be done by conducting hands-on training involving strategic partners. Partners involved in this activity include coffee farmers around KPH northern Banyuwangi, Perhutani, local community organizations (MWC NU, Karang Taruna) and coffee observers and activists in Banyuwangi Regency. The activities succeeded in increasing community knowledge about coffee trade prospects and quality coffee. The farmers have understood the market and provide quality coffee beans to meet market expectations. This activity improved the community's understanding of good coffee farming practices to produce quality coffee beans. Good cultivation is crucial to coffee's competitiveness and sustainability. This activity succeeded in improving the community's understanding of how to recognize coffee bean quality. The community gained basic knowledge related to basic organoleptic testing, but these skills need to be improved. Participants have been able to separate beans that are defective, broken, infested with fleas/insects, cracked, contain epidermis, and other characteristics that are not suitable as good quality coffee for processing. Overall the activity received good appreciation from the community, it is hoped that in the future assistance will continue.
Co-Authors Arif Nur Muhammad Ansori Arli Aditya Parikesit Brian Rahardi Jati Batoro Kharisma, Viol Dhea Luchman Hakim Moch Hardi Baramada Wicaksono Posa, Gabrielle Ann Villar Riyan Riyadlun Najih Rizky, Wahyu Choirur