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All Journal EKSAKTA: Journal of Sciences and Data Analysis Jurnal Ilmu Lingkungan Jurnal Vektor Penyakit Indonesian Journal of Tropical and Infectious Disease Jurnal Teknologi Laboratorium Indonesian Journal of Chemistry Biosaintifika: Journal of Biology & Biology Education Indian Journal of Forensic Medicine & Toxicology Makara Journal of Science
Arif Nur Muhammad Ansori
Fakultas Kedokteran Hewan Universitas Airlangga, Surabaya, Indonesia
Agriculture, Biological Sciences & Forestry Chemical Engineering, Chemistry & Bioengineering Chemistry Earth & Planetary Sciences Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health Veterinary Other

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Differences of Universal and Multiplex Primer for Detection of Dengue Virus from Patients Suspected Dengue Hemorrhagic Fever (DHF) in Surabaya Ansori, Arif; Sucipto, Teguh; Deka, Pemta; Ahwanah, Nur; Churrotin, Siti; Kotaki, Tomohiro; Soegijanto, Soegeng
Indonesian Journal of Tropical and Infectious Disease Vol 5, No 6 (2015)
Publisher : Institute of Topical Disease

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Dengue Hemorrhagic Fever (DHF) is a global health problem in tropical and subtropical regions, as well as endemic in110 countries around the world. Indonesia is one of the largest countries in the region of endemic dengue. In Indonesia, dengue virus infection has become a contagious disease that was very important and was reported in 1968. Many molecular epidemiological approaches have been developed to look for factor that has been assumed as the cause of the increase of prevalence dengue virus infection in the world. The aim of this study is for the detection and determination of serotype of dengue virus in Surabaya. The method used was the technique of Reverse Transcription-Polymerase Chain Reaction (RT-PCR) and Polymerase Chain Reaction (PCR) with specific primers for dengue virus. Samples suspected DHF patients were obtained from various health center and hospital in Surabaya. Results of this research detected negative result for dengue virus in all samples of patients suspected DHF. Negative results caused by dengue virus titers in serum samples of patients who had been dropped due to long storage time and taken after the third day of fever in early period.
Callus Induction of Gendarussa (Justicia gendarussa) by Various Concentration of 2,4-D, IBA, and BAP Wahyuni, Dwi Kusuma; Andriani, Putri; Ansori, Arif Nur Muhammad; Utami, Edy Setiti Wida
Biosaintifika: Journal of Biology & Biology Education Vol 9, No 3 (2017): December 2017
Publisher : Department of Biology, Faculty of Mathematics and Sciences, Semarang State University . Ro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/biosaintifika.v9i3.11347

Abstract

Justicia gendarussa Burm.f., a medicinal plant, is Acanthaceae that has many functions. Furthermore, the compounds in gendarussa must be produced in high quantity and quality by applying callus culture method. Accordingly, it is important to study the effects of plant growth regulators (2,4-D, IBA, and BAP) on callus induction of gendarussa leaves. This research design utilized a factorial design with two factors (2,4-D and IBA: 0.5, 1, 1.5 mg/L and BAP: 0.5, 1, 1.5, 2 mg/L). The experiment consisted of 24 treatments, each of which was repeated 3 times. Observation was carried out in 6 weeks. Data on the time of callus formation, percentage of explants formed callus, and callus morphology were analyzed descriptively,while data on fresh and dry weight were analyzed by Two-Way ANOVA (? = 0.5). Interestingly, the results showed that various concentration of plant growth regulators (2,4-D, IBA, and BAP) affected callus induction from leaf explants of gendarussa. We concluded that the most optimal treatment combination of concentration of plant growth regulators in inducing callus from leaf explants of gendarussa is 1.5 mg/L 2,4-D and 2 mg/L BAP with a relatively long period of callus formation at the earliest, i.e. on day 5, 2.247 g of fresh weight, 0.108 gof dry weight, white callus translucent, and friable. Moreover, the optimum treatment will be used to produce secondary metabolite and seed synthetic by cell suspension culture.
Immunobioinformatics analysis and phylogenetic tree construction of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Indonesia: spike glycoprotein gene Ansori, Arif Nur Muhammad; Kharisma, Viol Dhea; Antonius, Yulanda; Tacharina, Martia Rani; Rantam, Fedik Abdul
Jurnal Teknologi Laboratorium Vol 9 No 1 (2020): 2020 (1): Special Edition "COVID-19"
Publisher : POLTEKKES KEMENKES YOGYAKARTA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (986.383 KB) | DOI: 10.29238/teknolabjournal.v9i1.221

Abstract

The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus disease 2019 (COVID-19), has spread worldwide and as a result, the World Health Organization (WHO) declared it a pandemic. At present, there are no approved vaccines against SARS-CoV-2. Therefore, the aim of this study was to predict epitope-based vaccines using bioinformatics approaches and phylogenetic tree construction of SARS-CoV-2 against the backdrop of the COVID-19 pandemic. In this study, we employed 27 isolates of SARS-CoV-2 spike glycoprotein genes retrieved from GenBank® (National Center for Biotechnology Information, USA) and the GISAID EpiCoV™ Database (Germany). We analyzed the candidate epitopes using the Immune Epitope Database and Analysis Resource. Furthermore, we performed a protective antigen prediction with VaxiJen 2.0. Data for B-cell epitope prediction, protective antigen prediction, and the underlying phylogenetic tree of SARS-CoV-2 were obtained in this research. Therefore, these data could be used to design an epitope-based vaccine against SARS-CoV-2. However, the advanced study is recommended for confirmation (in vitro and in vivo).
First Report of Protein and Fat Level of Alabio Duck (Anas platyrhynchos Borneo) Eggs in Hulu Sungai Utara, Indonesia for Improving Human Health Rini Fajarwati1 , Arif Nur Muhammad Ansori2 , Sri Pantja Madyawati3
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 4 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i4.12152

Abstract

Indonesian local ducks are native germplasm of Indonesia which has the genetic quality and has the potentialto be developed as a productive egg producer. Each type of duck has a different chemical compositionin their eggs. The purpose of this study is to find out the levels of protein and fat in Alabio duck (Anasplatyrhynchos Borneo) eggs in Hambuku Raya Village and Putat Atas Village, Hulu Sungai Utara, SouthKalimantan, Indonesia. This study used a completely randomized design (CRD). Interestingly, we showedthat the level of protein and fat in Alabio duck eggs was relatively good. Therefore, this finding is the basicdata for further research on Alabio duck in the future.
Molecular Mechanism of Caffeine-Aspirin Interaction in Kopi Balur 1 as Anti-Inflammatory Agent: A Computational Study Viol Dhea Kharisma1,2, Arif Nur Muhammad Ansori2,3, Amaq Fadholly3 , Teguh Hari Sucipto4
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 4 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i4.12274

Abstract

Balur treatment (BT) is a method that works to remove toxins in the form of free radicals released via theskin. One of the remedies used is Kopi Balur 1 (KB1) which contains aspirin and caffeine used duringthe BT, so that KB1 is believed to have the potential to reduce or inhibit the occurrence of inflammatoryprocesses in the body. Therefore, we investigate the interactions that occur between ligands and proteins,predict the action mode of caffeine-aspirin contained in KB1 as an anti-inflammatory agent, and modelingthe 3D structure of pro-inflammatory proteins in the human body. The target compound, aspirin-caffein,was obtained from a database, then used to identify the pathway on the STITCH webserver, then the targetprotein was obtained and modeled in 3D using the SWISS-MODEL webserver, and the structures obtainedwere represented in PyMol software. In sum, the aspirin-caffeine ligand complex contained in KB1 has thepotential as an anti-inflammatory agent in the human body via the molecular mechanism of binding andinhibiting the biological activity of proinflammatory proteins, i.e. PTGS1, PTGS2, and ADOR2A.
Biological Activity Investigation of Phytocomponents in Mangosteen (Garcinia mangostana L.): In Silico Study Arif Nur Muhammad Ansori1 , Raden Joko Kuncoroningrat Susilo2 , Suhailah Hayaza2
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 1 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i1.13522

Abstract

Indonesia has abundant medicinal plants, which have been historically used by the population in treatingdiseases for generations. Traditional Indonesian medicine and the medicinal plants used could lead to thediscovery of novel drugs. The mangosteen or Garcinia mangostana L. is a well-known medicinal plantthat has been used to treat various diseases worldwide. The pharmacological activities and phytochemicalcomposition of the whole plant of mangosteen have been investigated and identified by scientists in recentdecades. Therefore, this study aims to generate the prediction of the biological activity of phytocompotentsin mangosteen. In this study, we extracted 18 phyocomponents of mangosteen from PubChem, an openchemistry database at the National Institutes of Health (NIH), USA. Then, we predicted the pharmacokineticproperties and druglike nature of the phytocomponents using the SwissADME web server, Swiss Instituteof Bioinformatics, Swiss. Furthermore, PASS (Prediction of Activity Spectra for Substances) web resourcehas been employed as a strong potential tool to predict the biological activity. In summary, we revealed thebiological activity of 18 phytocomponents of the mangosteen. However, further trials, such as in vitro andin vivo evaluation, are needed to prove the validity of these findings.
A Mini-Review of the Medicinal Properties of Okra (Abelmoschus esculentus L.) and Potential Benefit against SARS-CoV-2 Arif Nur Muhammad Ansori
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 1 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i1.13523

Abstract

Indonesia is rich in medicinal plants, where its population has traditionally used them for generations tocure diseases. Traditional medicine and medicinal plants from Indonesia may lead to the discovery of noveldrugs. Abelmoschus esculentus L. or okra is well known as a cure for several diseases and is includedin various folk medicinal stockpiles. In recent decades, scientists have discovered the phytochemicalcomposition in the whole okra plant, as well as its pharmacological activities. These studies establishedthe therapeutic potential of okra for drug discovery. Therefore, the present review provides a sneak peek ofokra’s pharmacology and phytochemistry, also the potential benefit against SARS-CoV-2.
Conserved B-cell epitope identification of envelope glycoprotein (GP120) HIV-1 to develop multi-strain vaccine candidate through bioinformatics approach Kharisma, Viol Dhea; Ansori, Arif Nur Muhammad; Posa, Gabrielle Ann Villar; Rizky, Wahyu Choirur; Permana, Sofy; Parikesit, Arli Aditya
Jurnal Teknologi Laboratorium Vol 10 No 1 (2021): inpress
Publisher : POLTEKKES KEMENKES YOGYAKARTA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29238/teknolabjournal.v10i1.274

Abstract

Acquired immune deficiency syndrome (AIDS) has been identified from US patients since 1981. AIDS is caused by infection with the human immunodeficiency virus type 1 (HIV-1) which is a retrovirus. HIV-1 gp120 can be recognized by the immune system because it is located outside the virion. The conserved region is identified in gp120, and it is recognized by an immune cell which then initiates specific immune responses, viral mutation escape, and increase vaccine protection coverage, a benefit derived from the conserved region-based vaccine design. However, previous researchers have little knowledge on this conserved region as a target for vaccine design. This paper explains how the conserved region of gp120 HIV-1 is a major target for vaccine design through a bioinformatics approach. The conserved region from gp120 was explored as a vaccine design target with a bioinformatics tool that consists of B-cell epitope mapping, vaccine properties, molecular docking, and dynamic simulation. The peptide vaccine candidate of B5 with the gp120 HIV-1 conserved region was found to provoke B-cell activation through a direct pathway, produce specific antibody, and increase protection from multi-strain viral infection.
Concept of SARS-CoV-2 Vaccine Design to Fight COVID-19 Pandemic: A Review Insight Viol Dhea Kharisma; Arif Nur Muhammad Ansori; Rasyadan Taufiq Probojati; Dora Dayu Rahma Turista; Yulanda Antonius
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 4 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i4.17127

Abstract

Cluster of pneumonia infection emerged in Wuhan, China due to severe acute respiratory syndromecoronavirus 2 (SARS-CoV-2). Additionally, more than 190 countries have confirmed 82 million casesof SARS-CoV-2 infection. Currently, there is a SARS-CoV-2 epidemic, and no effective prophylacticmethods are available. A vaccine is considered as an effective method to restrict an epidemic. Severalvaccine designing techniques have been established, which is enabling researchers from various institutesfor developing vaccine towards SARS-CoV-2 infections. In this review, we condense the development ofvaccine research against SARS-CoV-2.
Alpha-Mangostin and Gamma-Mangostin Isolated from Mangosteen (Garcinia mangostana L.) as Promising Candidates against SARS-CoV-2: A Bioinformatics Approach Arif Nur Muhammad Ansori
Indian Journal of Forensic Medicine & Toxicology Vol. 16 No. 1 (2022): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v16i1.17461

Abstract

The world is endangered by the COVID‐19 pandemic caused by SARS‐CoV‐2, people are dying in thousands every day, and without an actual treatment, it seems that bringing this global health problem to a quit is impossible. Natural products have been in constant use since ancient times and are proven by time to be effective. Medicinal plants from Indonesia may lead to the discovery of the novel drugs. Mangosteen or Garcinia mangostana L. is a native tropical fruit from Southeast Asia and is known to contain bioactive compounds. Interestingly, the main xanthone derivatives are alpha-mangostin and gamma-mangostin, these compounds have a variety of pharmacological activities such as antiviral activity. In summary, this study showed potential pharmacological benefits of alpha-mangostin and gamma-mangostin isolated from mangosteen against SARS-CoV-2. Thus, mangosteen exhibits as a valuable plant and a candidate for future drug development to fight SARS-CoV-2. However, further trials, such as in vitro and in vivo evaluation, are needed to prove the validity of these findings
Co-Authors Alyaa Farrah Dibha Arli Aditya Parikesit Arli Aditya Parikesit Astria Novitasari Nidom Balqis Afifah Cinantya Dwi Jayanti Dhani Prakoso Dwi Kusuma Wahyuni Edy Setiti Wida Utami Erindra Budi Cahyanto Fedik Abdul Rantam Hafi Nurinasari Hafidzhah, Muhammad Aldino Hamidah Hamidah Haris Nur Ashfi Arifa Hebert Adrianto I Gede Widhiantara I Made Gde Sudyadnyana Sandhika I Wayan Rosiana Imam Mustofa Kharisma, Viol Dhea Kuncoro Puguh Santoso Maksim Rebezov Maria Kiseleva Maulina, Rufidah Mayadita Dwi Sani Muhammad Hermawan Widyananda Muhammad Khaliim Jati Kusala Nadezhda Kenijz Nanda Yuli Rahmawati Nidom, Chairul Anwar Nor Laela Ramadhaniyah Nur Ahwanah, Nur Pemta Deka, Pemta Posa, Gabrielle Ann Villar Putri Andriani Putri Andriani Putu Angga Wiradana Putu Eka Sudaryatma Rahadian Zainul Rahmahani, Jola Rasyadan Taufiq Probojati Revi Gama Hatta Novika Reviany Vibrianita Nidom Rizky, Wahyu Choirur Setyarina Indrasari Siti Churrotin, Siti Siti Nurhidayati Soegeng Soegijanto Soeharsono Soeharsono Soetrisno Soetrisno Sofy Permana Sri Wahyuningsih Svetlana Artyukhova Tacharina, Martia Rani Teguh Sucipto, Teguh Tomohiro Kotaki, Tomohiro Turista, Dora Dayu Rahma Ummul Firmani Vikash Jakhmola Viol Dhea Kharisma Viol Dhea Kharisma Viol Dhea Kharisma Viol Dhea Kharisma Wijaya, Renadya Maulani Yulanda Antonius Yulia Matrosova