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All Journal Science and Technology Indonesia Journal of Midwifery and Nursing Best Journal (Biology Education, Sains and Technology) Herbal Medicine Journal
Faisal Yusuf
1 Institut Kesehatan Deli Husada Deli Tua 23 Sekolah Tinggi Ilmu Kesehatan Arjuna
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Physics Public Health

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Tlc Profile And Antifungal Activity Test Of Ethylacetat Extract Of The Flower Moon Herbs (Tithoniadiversifolia (Hemsl.) Gray) Againts Candida Albicans And Microsporum Canis Hepni Hepni; Fitri Yanti; Faisal Yusuf
Journal of Midwifery and Nursing Vol. 4 No. 2 (2022): Health Science
Publisher : Institute Of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/jmn.v4i2.2183

Abstract

The moon flower herb is a plant species known and used as traditional medicine in Indonesia for generations. In previous studies it was known that moonflower (Tithonia diversifolia (Hemsl) Gray) has antihyperglycemic, antidiabetic, antimicrobial and antimalarial effects, and it is known that the roots, stems, leaves and essential oil of moonflower (Tithonia diversifolia (Hemsl) Gray) contain alkaloids, compounds phenolics, steroids, saponins and flavonoids. The purpose of this study was to determine the activity of ethylacetate extract of moonflower herb against Candida albicans and Microsporum canis. This research was carried out in several stages, starting with the process of collecting and processing samples, testing the characteristics of simplicia, maceration of the ethylacetate extract of the moonflower herb (Tithonia diversifolia (Hemsl) Grey), testing Thin Layer Chromatography (TLC) and testing antifungal activity. The results of the research that the moon flower herb has a water content of about 10.2%. Thin Layer Chromatography (TLC) test of moonflower herbs on ethyl acetate extract containing polyphenolic compounds, steroids and alkaloids. The minimum inhibitory concentration (MIC) of ethylacetate extract of moonflower herb against Candida albicans ATCC 10231 was at a concentration of 200 mg/mL, ie 3.00 mm, while in Microsporum canis it was found at a concentration of 300 mg/mL. which is equal to 13.21mm.
Development and Validation of Fast and Simple Fourier Transform Infrared Spectrophotometric Method for Analysis of Thiamphenicol in Capsule Dosage Form Nerdy Nerdy; Linda Margata; Nilsya Febrika Zebua; Puji Lestari; Tedy Kurniawan Bakri; Faisal Yusuf; Vonna Aulianshah
Science and Technology Indonesia Vol. 8 No. 3 (2023): July
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2023.8.3.344-352

Abstract

The development of a method for identification and determination of thiamphenicol by Fourier Transform Infrared will provide convenience to developers because it is fast and easy for analysis. The research was carried out by utilizing the solubility of thiamphenicol in methanol with three stages, namely method development, sample analysis, and method validation. The method development stage showed that the specific peak of thiamphenicol was at a peak with a wavenumber of 1694.1 cm−1; this specific peak of thiamphenicol was used for qualitative analysis and quantitative analysis of thiamphenicol in the capsule dosage form. The sample analysis showed that all analyzed thiamphenicol in capsule dosage form showed good results both qualitatively and quantitatively. Qualitatively all the samples analyzed showed a specific peak at specific positions and specific wavenumbers. These results meet the requirements for containing thiamphenicol in the dosage form. Quantitatively all the samples analyzed ranged from 97.97% to 102.24% by peak height and peak area. These results meet the requirements for active substance levels in general preparations within 90.0% to 110.0%. The method validation for peak height and peak area showed that the accuracy parameter had a recovery percentage of 100.28% and 100.41% (between 98.0% to 102.0%), the precision parameter with a relative standard deviation of 0.31% and 0.37% (not more than 2.0%), and the linearity parameter with a correlation coefficient of 0.9999 and 0.9997 (not less than 0.99). The limit of detection value was 0.2971 mg/mL and 0.5338 mg/mL, the limit of quantitation value was 0.9004 mg/mL and 1.6176 mg/mL, the range for both was 80% to 120%, and the specificity for both met the requirement. The Fourier Transform Infrared method has been successfully developed, applied, and validated for qualitative analysis and quantitative analysis of thiamphenicol in capsule dosage form.
Karakterisasi Simplisia Dan Skrining Fitokimia Herba Suruhan (Peperomia pellucida H.B.&K.) Puji Lestari; Faisal Yusuf; Firdaus Fahdi
BEST Journal (Biology Education, Sains and Technology) Vol 6, No 2 (2023): September 2023
Publisher : Program Studi Pendidikan Biologi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30743/best.v6i2.9699

Abstract

Latar belakang: Simplisia adalah bahan alami yang dapat digunakan sebagai obat tradisional, yang dalam praktiknya belum mengalami pengolahan lebih lanjut selain proses pengeringan Salah satu tumbuhan obat yang dapat digunakan sebagai obat tradisional adalah herba suruhan (Peperomia pellucida H.B.K.). Simplisia sebagai bahan baku ekstrak harus memenuhi persyaratan yang tercantum dalam monografi buku Materia Medika Indonesia. Tujuan: Penelitian ini bertujuan untuk mengetahui karakterisasi simplisia dan skrining fitokimia dari simplisia herba suruhan standar mutu dan keamanan dari bahan baku obat tradisional. Hasil: Diperoleh kadar sari yang larut dalam air 18,8%, kadar sari yang larut dalam etanol 12,83%, kadar abu total  3,85 %, kadar abu yang tidak larut dalam asam 1,17 % dan kadar air 6,66 %. Hasil pemeriksaan mikroskopik serbuk simplisia dijumpai adanya rambut penutup, parenkim, berkas pembuluh dengan penebalan spiral, tetes minyak, stomata tipe anomositik, pada tulang daun terdapat berkas pembuluh dan hablur kalsium oksalat berbentuk drusse dan persegi, sel batu dan sel epidermis. Skrining fitokimia terhadap serbuk simplisia menunjukkan adanya senyawa golongan flavonoida, glikosida, tannin dan triterpenoida/steroida bebas. Kesimpulan: Hasil pemeriksaan karakterisasi simplisia herba suruhan (Peperomia pellucida H.B.K.) memenuhi syarat dimana kadar sari yang larut dalam air 18,8%, kadar sari yang larut dalam etanol 12,83%, kadar abu total  3,85 %, kadar abu yang tidak larut dalam asam 1,17% dan kadar air 6,66 %.
Uji Efektivitas Antibakteri Ekstrak Metanol Kulit Batang Pohon Raru (Cotylelobium melanoxylon Pierre) Terhadap Bakteri Staphylococcus aureus, Escherichia coli Hepni Sibagariang; Faisal Yusuf; Sherly H. Hutagaol; Lamro Manalu
Herbal Medicine Journal Vol 9 No 2 (2026): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58996/hmj.v9i2.175

Abstract

The bark of the raru tree possesses bioactive compounds with promising antibacterial properties. Compounds such as flavonoids, alkaloids, tannins, and saponins are known for their ability to suppress bacterial proliferation. This research investigates the antibacterial activity of methanolic extracts derived from raru bark against Staphylococcus aureus and Escherichia coli. A series of laboratory-based assays were conducted, employing raru bark extract (Cotylelobium melanoxylon Pierre) at concentrations of 25%, 50%, 75%, and 100%, utilizing the diffusion technique to assess its inhibitory effects. The findings indicate that a 25% concentration of raru bark extract produces an inhibition zone of 12.43 mm against Staphylococcus aureus and 13.26 mm against Escherichia coli, both reflecting a substantial antimicrobial effect. At a 50% concentration, the extract demonstrates enhanced activity, yielding inhibition zones of 16.91 mm and 17.05 mm for S. aureus and E. coli, respectively still within the strong efficacy range. Increasing the concentration to 75% further amplifies the antibacterial impact, with zone diameters reaching 20.26 mm for S. aureus and 20.00 mm for E. coli. At full strength (100% concentration), the extract exhibits pronounced antimicrobial potency, forming inhibition zones of 24.95 mm and 24.88 mm for S. aureus and E. coli, respectively, indicating a very strong antibacterial capacity.
Co-Authors Firdaus Fahdi Fitri Yanti Hepni Hepni Hepni Sibagariang Lamro Manalu Linda Margata Nerdy, Nerdy Nilsya Febrika Zebua, Nilsya Febrika Puji Lestari Puji Lestari Sherly H. Hutagaol Tedy Kurniawan Bakri Vonna Aulianshah