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All Journal Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Medical Journal of Indonesia YARSI Medical Journal
Praseno Praseno
Department of Microbiology, Faculty of Medicine, Gadjah Mada University, Yogyakarta
Immunology & microbiology Medicine & Pharmacology Neuroscience

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Journal : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Comparative efficacy of Phyllanthus niruri L. and cotrimoxazole in the treatment of skin infection caused by Staphylococcus aureus. Praseno, Praseno
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 33, No 02 (2001)
Publisher : Universitas Gadjah Mada

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Abstract

Background: Traditional medicine has been widely used in our community and many of them were found to be effective in the treatment of various diseases. Previous studies showed that Phyllanthus niruri L. has an effect as immunostimulator and antiviral activities.Objective: The aim of this study was to evaluate the efficacy of Phyllanthus niruri L. in the treatment of skin infection caused by Staphylococcus aureus.Materials and Methods: Thirty mice of Swiss strain were infected with 2x100 colony forming unit of S.aureus subcutaneously. The mice were then devided into 3 groups; Phyllanthus niruri L.-treated group, cotrimoxazole-treated group, and control group. Treatmen
Antiviral activity of Momordica charantia: a preliminary study on in vitro anti herpes simplex virus Praseno, Praseno
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 29, No 03 (1997)
Publisher : Universitas Gadjah Mada

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Abstract

Traditional medication has been used by Indonesian people since long time ago and still continuing up to the present time. Many of them proved to be effective in curing various diseases. In this study an in vitro activity of Momordica charantia againts Herpes Simplex Virus type 2 has been evaluated by standard method of plaque reduction assay. The aim of this study is to determine whether traditional medicine we are searching has an antiviral activity. The results showed that total inhibition of plaque formation on HSV 2-infected Vero cell line was achieved at concentration of 8% v/v of crude extract, whereas the concentration of 1% v/v was capable of reducing the number of plaques by approximately 50% (inhibitory dose50= ID50). These results were very interesting as even with only small amount of crude extract we could get ID50. We expect that much lower concentration will be required to obtain ID50 if we use purified extract in the assay. Further studies are needed to elucidate other properties of the extract, including its in vivo antiviral activity, possible effect on other viruses, and mechanism of action.Key words: antiviral activity - herpes simplex virus - Momordica charantia - traditional medicine - plaque reduction assay
Co-Authors Fiatiningsih, Istiana Nurrokhman, Nurrokhman Suwarso Suwarso