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Heda Melinda Nataprawira
Department of Child Health, Padjadjaran University Medical School/Dr. Hasan Sadikin Hospital, Bandung, Indonesia
Health Professions Medicine & Pharmacology

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Serum interleukin-6 and mean platelet volume in pediatric pneumonia Melisa Lilisari; Heda Melinda Nataprawira; Dida Akhmad Gurnida
Paediatrica Indonesiana Vol 56 No 1 (2016): January 2016
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (269.186 KB) | DOI: 10.14238/pi56.1.2016.57-61

Abstract

Background In pneumonia, interleukin (IL)-6 is released in response to inflammation. Interleukin-6 stimulates megakaryocyte maturation, leading to larger platelets being released into the circulation. Platelet size is measured as mean platelet volume (MPV). The MPV may also be affected by nutritional status and smoking.Objective To assess for a possible relationship between serum IL-6 concentration and MPV, including smoking and nutritional status as confounding factors, in children with pneumonia.Methods An analytic, observational study with cross-sectional design and consecutive sampling of children aged 2 to 59 months with a clinical diagnosis of pneumonia was conducted from November 2013 to March 2014 in Dr. Hasan Sadikin General Hospital and two network hospitals. All patients underwent routine complete blood counts including MPV and measurement of serum IL-6 concentration using an enzyme-linked immunosorbent assay (ELISA) technique. Regression linear analysis was used to assess the relationship between MPV and IL-6, passive smoking, and nutritional status.Results There were 67 patients enrolled in the study. Subjects’ mean serum IL-6 concentration was 49.3 (SD 78.3) pg/mL, and mean MPV was 9.2 (SD 0.9) fL. The regression model for MPV was 7.531 + 0.662 (passive smoking) + 0.276 (weight per age) + 0.009 (IL-6).Conclusion There was a relationship between IL-6 serum concentration and MPV in children with pneumonia.
Co-Authors Dida Akhmad Gurnida Melisa Lilisari