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All Journal Paediatrica Indonesiana Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Plexus Medical Journal
Iffa Mutmainah
Division Of Human Genetics, Center For Biomedical Research (CEBIOR), Diponegoro University Medical School, Semarang, Indonesia, And The Department Of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands
Biochemistry, Genetics & Molecular Biology Education Health Professions Medicine & Pharmacology Public Health

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Clinical and molecular analysis of Noonan syndrome in Indonesia: a case report Iffa Mutmainah; Willy Nillesen; Farmaditya Mundhofir; Tri Winarni; Ineke van der Burgt; Helger Yntema; Sultana Faradz
Paediatrica Indonesiana Vol 56 No 1 (2016): January 2016
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (488.374 KB) | DOI: 10.14238/pi56.1.2016.62-6

Abstract

Noonan syndrome (NS; OMIM#163950) is a relatively common autosomal dominant disorder with a worldwide prevalence of approximately 1:1,000 to 1:2,500. The syndrome is characterized by distinctive facial features, congenital heart defects (CHD), and short stature. Distinctive facial features consist of a broad and high forehead, hypertelorism, downslanting palpebral fissures, a high arched palate, low set and posteriorly rotated ears with a thick helix, and a short neck with excess nuchal skin and low posterior hairline. Additional relatively frequent features include chest deformities, cryptorchidism in males, mild intellectual disability, and bleeding diathesis.1,2In 2001, missense mutations in
A COVID-19 Ringan Pada Tenaga Medis: Evaluasi Temuan Klinis dan Risiko Transmisi Mahrani; Hana Khairina Putri Faisal; Paramita Khairan; Iffa Mutmainah; Fitriana Nur Rahmawati; Sarah Shafa Marwadhani; Gadistya Novitri Adinda; Uti Sari; Pukovisa Prawirohardjo
Majalah Kedokteran Indonesia Vol 70 No 4 (2020): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.70.4-2020-223

Abstract

Objective: Since December 2019, COVID-19 has become a global concern causing more than thousands of deaths worldwide. The major challenge in fighting against this new emerging disease is the limited data regarding the heterogeneity of its clinical and epidemiological features. We aim to fill this knowledge gap by evaluating a mild case of COVID-19 infecting a health worker in Indonesia.Method: We report a 31-year-old male doctor who was hospitalized for mild pneumonia with positive SARS-CoV-2 swab testResult: This case presents an estimated incubation period of 2 days. The patient showed mild upper respiratory symptoms without significant pneumonia symptoms, however mild pneumonia was confirmed by the presence of fever and pulmonary infiltrates on imaging. Despite the seemingly mild symptoms, there was a complex systemic reaction as thrombocytopenia and elevated aminotransferase enzyme occurred. The patient is a health worker susceptible to SARS-CoV-2 transmission with a close contact history with a suspected COVID-19 patient, without wearing an adequate personal protective equipment (PPE).Conclusion: Patients with mild presentation of COVID-19 could exhibit a complex systemic reaction and organ injury. The use of an appropriate PPE among health workers is crucial to prevent patient-to-doctor transmission.
Efek Asam Klorogenat pada Ekspresi Mrna IL-6 dan CD86 Lobus Frontal Tikus Model Diabetes Mellitus Munawaroh, Fauziyatul; Hanif , Aisyah Amanda; Ragil Kemuning, Asri; Mutmainah, Iffa; Rachmawati, Yenny; Muharam Nurdin, Naufal
Plexus Medical Journal Vol. 3 No. 4 (2024): Agustus
Publisher : Fakultas Kedokteran, Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/plexus.v3i4.1815

Abstract

Pendahuluan: Diabetes Mellitus (DM) merupakan penyakit kronik dengan berbagai komplikasi, salah satunya yaitu Encephalopati Diabetikum (ED). Hiperglikemia pada DM akan mengakibatkan neuroinflamasi melalui jalur M1 proinflamatorik. Beberapa agen proinflamatori akan meningkat dengan aktifnya jalur ini, seperti IL-6. Neuroglia kemudian teraktivasi dan mengekspresikan CD86 pada membran sel. Asam klorogenat (CGA) merupakan senyawa polyphenol pada kopi  yang  memiliki  efek antiinflamasi.  Tujuan penelitian ini adalah untuk memperjelas efek CGA pada aktivasi mikroglia jalur M1 dengan melihat ekspresi mRNA IL-6 dan CD86 pada lobus frontal tikus dengan model DM. Metode: 24 ekor tikus jantan secara acak dibagi menjadi enam kelompok yaitu :  kontrol,   DM 1,5 bulan dan DM 2 bulan,  dan kelompok dengan pemberian  CGA dengan  tiga  dosis  berbeda  (CGA1,  CGA2,  CGA3).  Jaringan lobus frontal diambil untuk analisa ekspresi mRNA IL-6 dan CD86 menggunakan RT-PCR. Hasil: Ekspresi mRNA IL-6 lobus frontal berbeda signifikan antara kelompok kontrol dengan DM1,5 (p=0.010); kontrol dengan DM2 (p=0.001); kelompok DM2 dengan CGA2 (p=0.028). Ekspresi mRNA CD86 lobus frontal trdapat perbedaan signifikan antara kelompok kontrol dengan semua kelompok DM, baik dengan CGA atau tanpa CGA (p<0.05). Kelompok DM2 berbeda signifikan dengan kelompok CGA2 (p=0.000) dan kelompok CGA3 (p=0,000). Kesimpulan: Ekspresi mRNA penanda jaras proinflamatorik M1 (IL-6 dan CD86) pada neuroinflamasi lobus frontal akibat DM lebih rendah setelah pemberian CGA dengan dosis 25 mg/KgBB.
Abses Paru pada COVID-19 Kurniawan, Adi; Khairan, Paramita; Librianty, Nurfanida; Mahrani, Mahrani; Faisal, Hana; Mutmainah, Iffa; Rahmawati, Fitriana Nur; Marwadhani, Sarah Shafa; Adinda, Gadistya Novitri; Sari, Uti Nilam; Prawirohardjo, Pukovisa
Majalah Kedokteran Indonesia Vol 70 No 8 (2020): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.70.8-2020-255

Abstract

Objective: COVID-19 is a new emerging disease since December 2019 that later was announced by WHO as a global pandemic. Radioimaging appearance of COVID-19 is varied yet dominantly showed as a ground glass appearance in CT-imaging. Lung abscess in COVID-19 is an extremely rare case, therefore it needs further discussion. Method: We report a 39 year-old male patient of COVID-19 with lung abscess.Result: This case report describe a COVID-19 patient who showed a very rare clinical manifestation; lung abscess. The patient showed negative result of TB molecular test. Chest tube insertion procedure was performed in this patient who showed an improvement after abscess being drained. Conclusion: Lung abscess may occur in COVID-19. Abscess drainage procedure may improve clinical condition of COVID-19 patient.
Co-Authors Adi Kurniawan Adinda, Gadistya Novitri Aisyah Amanda Hanif Asri Ragil Kemuning Faisal, Hana Farmaditya Mundhofir Fitriana Nur Rahmawati Gadistya Novitri Adinda Hana Khairina Putri Faisal Helger Yntema Ineke van der Burgt Librianty, Nurfanida Mahrani Mahrani, Mahrani Marwadhani, Sarah Shafa Munawaroh, Fauziyatul Naufal Muharam Nurdin Paramita Khairan Paramita Khairan, Paramita Prawirohardjo, Pukovisa Pukovisa Prawiroharjo Rachmawati, Yenny Rahmawati, Fitriana Nur Sarah Shafa Marwadhani Sari, Uti Nilam Sultana Faradz Tri Winarni Uti Sari Willy Nillesen