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Sri Sudaryati Nasar
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Health Professions Medicine & Pharmacology

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Plasma lipid profile and leptin concentration in super-obese children Aryono Hendarto; Sri Sudaryati Nasar; Damayanti Rusli Sjarif
Paediatrica Indonesiana Vol 47 No 5 (2007): September 2007
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (209.747 KB) | DOI: 10.14238/pi47.5.2007.221-5

Abstract

Background Leptin induced weight loss is completely specificfor adipose tissue loss, whereas food restriction result in both lossof adipose tissue and lean body mass in mammals. Most obeseperson has high endogenous leptin levels, indicating leptinresistance. There has been lack of data regarding plasma leptinlevel in Indonesian obese children.Objective This study was aimed to investigate the plasma leptinlevel and lipid profile in super-obese children.Methods This was a cross sectional study performed in PediatricOut Patient Clinic Mangunkusumo Hospital and Private Women& Children Hospital in Eastern part of Jakarta. Super-obese isdefined as children with BMI above 97 centiles CDC 2000 chart.Blood sample was obtained from all subjects, consisted ofperipheral blood picture, lipid profiles and leptin level.Results Seventy nine super-obese children were eligible with ageranged between 12 months and 180 months and mean of age was84.9 months (SD 36.8). More than 60% subjects had high LDLcholesterol, while 19% had low HDL level. The lowest leptinblood level was 2.877 μ g/dL, while the highest was 70.430 μ g/dL(mean 23.990; SD 12.726). Forty five subjects, all boys, hadincreased plasma leptin level.Conclusions In super-obese children, most of the subjectexperienced hyperlipidemia (LDL cholesterol) followed byhypertriglyceridemia. There was small number of low HDLcholesterol found. Super-obese girls had normal serum leptin level,in contrast, more than 60% super-obese boys had elevated serumleptin level.
Relationships between plasma zinc and ferritin with nutritional status in thalassemic children Luszy Arijanty; Sri Sudaryati Nasar; Bambang Madiyono; Djajadiman Gatot
Paediatrica Indonesiana Vol 46 No 5 (2006): September 2006
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (398.546 KB) | DOI: 10.14238/pi46.5.2006.220-4

Abstract

Background Repeated blood transfusions in thalassemic chil-dren can lead to iron overload in the body. High ferritin level leadsto low plasma zinc status because of their competitive inhibition.Previous study found that there was a correlation between plasmazinc level and nutritional status.Objective To obtain plasma zinc level, to investigate the correla-tion between plasma zinc and ferritin, and the impact of plasmazinc on nutritional status in children with thallasemia.Methods A cross sectional study was conducted on 67 thalas-semic children. This study was performed at Thalassemia Center,Cipto Mangunkusumo Hospital, Jakarta, from 1 st until 31 st of March2005. The age of the patients ranged from 4 to 18 years, with fer-ritin levels more than 2000 ng/ml during the last 6 months or totaltransfusion more than 5 liters. The subjects were divided into 2groups, i.e. group 1 (4-10 years) and group 2 (>10-18 years). Di-etary intake was assessed by 3 day-dietary recall. The nutritionalstatus were judged by mid upper arm circumference (MUAC) forage and height for age (H/A). Venous blood was obtained to mea-sure plasma zinc and ferritin levels. Statistical analysis was doneby Student’s t-test (2-tailed) and linear regression analysis.Results We found that 42% subjects were well-nourished, 51%were undernourished, and 7% were severely malnourished. All sub-jects had low plasma zinc status 31.9 (SD 16.9) μg/dl. There was aweak negative correlation between plasma zinc and ferritin level (r= -0.282, P=0.021). Lower zinc intake was detected in 65 out of 67subjects.Conclusion All thalassemic children in our hospital had low plasmazinc level. There was a weak negative correlation between plasmazinc level and ferritin level. There was no significant correlationbetween plasma zinc status and nutritional status
Co-Authors Aryono Hendarto Bambang Madiyono Damayanti Rusli Sjarif Djajadiman Gatot Luszy Arijanty