Background: Inflationary pressures in Bengkulu Province have affected public purchasing power, real sector stability, and Islamic banking performance through increased Non-Performing Financing (NPF) risk and fluctuations in Third-Party Funds (DPK). In this context, the Financial Services Authority (OJK) issued OJK Regulation (POJK) No. 12 of 2023 on Sharia Business Units (UUS) as a policy to strengthen institutional structure, capital, governance, and Sharia compliance. Research Gap: While previous studies have examined OJK regulations from national perspectives, limited attention has been given to analyzing the implementation and effectiveness of POJK No. 12/2023 in mitigating inflationary impacts at the regional level, particularly in provinces with unique economic structures such as Bengkulu. Novelty: This study offers a novel contribution by integrating financial stability theory, Islamic economic principles (amanah, maslahah, adl), and regional economic data to analyze how regulatory frameworks can strengthen Islamic banking resilience against inflation in a predominantly agricultural region. Method: Using a descriptive qualitative approach with secondary data analysis (library research), data were collected from official reports published by OJK, Bank Indonesia, and BPS. Content analysis and qualitative descriptive analysis were employed through data reduction, narrative presentation, and conclusion drawing. Results: The findings indicate that POJK 12/2023 strengthens UUS through phased minimum core capital requirements, spin-off obligations, organizational structure strengthening, and stricter governance and compliance audits. Implementation in Bengkulu shows positive trends: DPK increased by 16.97%, NPF decreased by 46.19%, and MSME financing grew by 9.68%. However, challenges persist including low Islamic financial literacy (30-40%), food inflation pressures (4.2%), and capital constraints at parent banks. Conclusion: POJK 12/2023 contributes positively to Islamic banking resilience in Bengkulu; however, strengthening Islamic financial literacy, developing digital services, and addressing structural constraints remain essential for optimizing regulatory effectiveness.