Garuda - Garba Rujukan Digital

Endy Paryanto Prawirohartono

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Author-ID : 3455721

Health Professions Medicine & Pharmacology

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Articles

Association between nutritional status and outcome of childhood acute lymphoblastic leukemia treated with Wijaya Kusuma Protocol Fransiska Herintya; Sri Mulatsih; Endy Paryanto Prawirohartono
Paediatrica Indonesiana Vol 48 No 1 (2008): January 2008
Publisher : Indonesian Pediatric Society

Background Acute lymphoblastic leukemia (ALL) is the mostcommon malignancy in childhood. Malnutrition in malignancypatients including ALL is one of major problems. This conditionis found at the time of diagnosis as a result of the disease itself orafter, chemotherapy or radiation. Many studies have beenconducted to determine the relationship between nutritional stateand outcome of childhood ALL patients but the result was stillcontroversial.Objective To determine relative risk of death and relapse inchildhood standard-risk ALL who received therapy using WijayaKusuma protocol.Methods This was a retrospective cohort study. Newly-diagnosedpatients since May 1999-December 2004 were taken for this study.Body mass index was used to measure nutritional status for >2years old children, and weight-for-height was used for those of=2 years old. Data was obtained from Yogyakarta Pediatric CancerRegistry Dr. Sardjito Hospital. Chi-squared test was used to analyzethe proportion difference and risk relative was used to determinerisk for death and relapse.Results One-hundred and forty five patients included in this study.There was no association between nutritional state and relapse(RR 1.1, 95% CI 0.76;1.61). Logistic regression analysis showedthat there was association between nutritional state and death(RR 2.34, 95% CI 1.01;5.45). Sepsis and relapse have contributionto death as well (RR 6.75, 95% CI 2.9;15.4 and RR 3.2, 95% CI1. 3;8.08 respectively).Conclusion Nutritional status is not associatiated with relapsebut is associated with death of ALL children.

Effect of egg avoidance diet by nursing mothers on the incidence of atopic dermatitis in infants Neti Nurani; Endy Paryanto Prawirohartono; A. Samik Wahab
Paediatrica Indonesiana Vol 48 No 2 (2008): March 2008
Publisher : Indonesian Pediatric Society

Background The prevalence of allergic and atopic diseases hasincreased rapidly and remains a social as well as an economicproblem for the patients on account of its chronic nature. In orderto decrease the atopic diseases, especially atopic dermatitis ininfants, nursing mothers should avoid allergenic foods as apreventive sensitization. Egg allergy is the most common cause offood allergy, and is closely related to atopic dermatitis in children.Objective To determine whether egg avoidance diet by nursingmothers could decrease the incidence of atopic dermatitis ininfants.Method We conducted a parallel randomized-controlled trial.Seventy-nine subjects eligible for the study were divided into twogroups: egg avoidance and non-egg avoidance group. Blockrandomization is used for random allocation. Intervention startedsince mothers had had delivery until their children were 4 monthsold. The primary outcomes were clinical atopic dermatitis.Result Atopic dermatitis incidence in maternal egg avoidancegroup was significantly lower than non-avoidance group. Non-avoidance, family history of asthma, and maternal allergy are thefactors significantly influencing atopic dermatitis incidence (OR6.17; OR 4.73; OR 0.14), respectively.Conclusion Egg avoidance by nursing mothers could decrease theincidence of atopic dermatitis in infants. Non-egg avoidance andasthma in the families are factors significantly inducing the incidenceof atopic dermatitis.

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