Arwin Akib
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Characteristics of HIV-infected children born to HIV-positive mothers in Cipto Mangunkusumo Hospital between 2002 and 2007 Fransisca Mayer; Arwin Akib; Imam Boediman
Paediatrica Indonesiana Vol 49 No 2 (2009): March 2009
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (125.055 KB) | DOI: 10.14238/pi49.2.2009.112-8

Abstract

Background In 2003, the Joint United Nation Program onHIV/AIDS and the World Health Organisation estimatedthat there will be 36.2 million people living with HIV /AIDSthrougout the world by the end of2003, and that 2.1 millionof them will be children less than 15 years old. The profileof children with HIV in the Department of Child Health,Cipto Mangunkusumo Hospital has not been studied.Objective To identify the characteristics of HIV-infectedchildren born to HIV-positive mothers, and to evaluate thePrevention Programme for Mother-to-Child Transmissionat Cipto Mangunkusumo Hospital.Methods This was a cross-sectional study conductedbetween March and May 2008 based on medical records.The study population consisted of all mother-child pairswho were admitted between January 2002 and December2007.Results Between 2002 and 2007,342 children were born toHIV-infected mother, with 201 (58.5%) children contractingHIV The median age of children was 20 months. Therewere 121 (35.4%) cases involved in prevention of motherto-child transmission. Triple-drug antiretroviral therapywas prescribed to 78.1 o/o children. The most frequentmorbidities were chronic diarrhea, wasting syndrome, andoropharyngeal candidiasis. Thirty-six children died; mostlydue to sepsis (30.5%)Conclusion The majority of cases of HIV were between 1and 5 years old. The most frequent morbidities were chronicdiarrhea, wasting syndrome, and oropharyngeal candidiasis.Thirty-six children died mostly due to sepsis. The preven-tion program for mother-to-child transmission should beencouraged among pregnant women who are known to beHIV-positive.
Clinical and laboratory manifestations of childhood and adult-onset systemic lupus erythematosus in Cipto Mangunkusumo Hospital Syarif Faisal; Arwin Akib; Taralan Tambunan
Paediatrica Indonesiana Vol 43 No 6 (2003): November 2003
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (345.727 KB) | DOI: 10.14238/pi43.6.2003.199-204

Abstract

Background Childhood-onset SLE is more severe than the adult type.Objective To compare the clinical and laboratory manifestationsof childhood- and adult-onset systemic lupus erythematosus (SLE).Methods A retrospective study on child and adult SLE patientswas conducted in the Division of Pediatric Allergy and Immunol-ogy, Department of Child Health and Department of Internal Medi-cine, Medical School, University of Indonesia/CiptoMangunkusumoHospital (FKUI/RSCM) Jakarta.Subjects One hundred and twenty-nine subjects met the studycriteria consisting on 54 childhood- onset (41.9%), 75 adult-onset(58.1%), and 122 (94.6%) females and 7 (5.4%) males from Janu-ary 1995 until December 2000.Results Fever, arthralgia and vasculitis were the most frequentsigns found in both childhood-onset and adult-onset SLE. The liver,spleen, lymph nodes, cardiovascular, gastrointestinal tract, andeyes were the organs involved and significantly had a larger pro-portion in the childhood-onset. Decrease of C3 was more frequentlyfound in the childhood-onset. Out of 17 childhood-onset patientswho died, 13 died at the age of 0-11 year-old. Two of the adult-onset patients also died.Conclusion Childhood-onset SLE had some different character-istics compared to adult form
Antibiotic profile in pediatric wards, Department of Child Health, Cipto Mangunkusumo Hospital Amin Husni; Hardjono Abdoerrachman; Arwin Akib
Paediatrica Indonesiana Vol 44 No 2 (2004): March 2004
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (321.133 KB) | DOI: 10.14238/pi44.2.2004.46-50

Abstract

Introduction The medical profession has currently come to a con-clusion that the major problem in the future is failure of treatmentdue to antibiotic-resistant microorganisms.Objective The aim of this study was to determine the profile ofantibiotics used in the Pediatric Wards of Department of Child Health,Medical School, University of Indonesia, Cipto Mangunkusumo Hos-pital, Jakarta.Methods A descriptive retrospective study was conducted on all pa-tients hospitalized in the Pediatric Wards of Department of Child Health,Medical School, University of Indonesia, Cipto Mangunkusumo Hos-pital during June–July 2001. Data were obtained from the medicalrecords of the patients.Results Three hundreds and fifty-six hospitalized patients fulfilledthe inclusion criteria. The antibiotics were given to 48.7% of thepatients. The greatest user of antibiotics was the age group of 1-5year-old, 50% of patients had been given single antibiotic and therest given combined antibiotics. The ICU used antibiotics most fre-quently in contrast to the one-day care unit which used least. Thegreatest use of single antibiotic was in the class 1-2 wards whilecombined antibiotics were mostly used in the third class wards.Single antibiotics used were cefotaxime (49.4%), amoxicillin(20.7%), and ampicillin (11.55%). Combined antibiotics used wereampicillin + chloramphenicol (34.5%), cotrimoxazole (21.8%),cefotaxime + amikacin (5.7%), cefotaxime + cotrimoxazole (5.7%),and cefotaxime + isoniazid + rifampicin + pyrazinamide (5.7%).Conclusions The antibiotics most commonly used singly wascefotaxime. The combination of antibiotic mostly used was ampi-cillin + chloramphenicol
Delayed puberty in thalassemia major patients Jose RL Batubara; Arwin Akib; Diah Pramita
Paediatrica Indonesiana Vol 44 No 4 (2004): July 2004
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (418.943 KB) | DOI: 10.14238/pi44.4.2004.143-7

Abstract

Background Delayed puberty is the most common endocrine com-plication in thalassemia major. The main cause of delayed pu-berty in thalassemia major is the failure of the hypothalamic-pitu-itary axis due to iron accumulation in the pituitary.Objectives The purpose of this study was to determine the preva-lence of delayed puberty in β-thalassemia major patients in theDepartment of Child Health, Cipto Mangunkusumo Hospital,Jakarta. This study also evaluated the adequacy of chelationtherapy and determined serum gonadotropin and sex hormonelevels in these patients.Methods Seventy-two patients with β-thalassemia major aged 13-18 years old who visited the Thalassemia Outpatient Clinic of CiptoMangunkusumo Hospital during February-July 2003 were includedin the study. Each subject underwent examinations to determinethe body weight and height, pubertal status, serum iron level, totaliron binding capacity, and the levels of serum LH, FSH, estradiol(in girls) or testosterone (in boys).Results Delayed puberty occurred in 40 of 72 patients (56%). Themajority of patients with delayed puberty showed low levels of se-rum LH, estradiol, and testosterone whereas low levels of serumFSH only occurred in 6 of 21 boys and 11 of 19 girls. Most of thepatients without delayed puberty had normal levels of serum LH,FSH, and estradiol, but 8 of 16 boys showed decreased serumtestosterone levels. Only 3 patients used chelation therapy ad-equately, all of them showed normal puberty.Conclusions The prevalence of delayed puberty in β-thalassemiamajor patients in this study was still high (56%). Periodic examina-tion and recording of pubertal stage need to be done in girls whohave reached 8 years old and boys who have reached 9 years oldso that early detection and management of delayed puberty canbe done.