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All Journal Paediatrica Indonesiana Indonesian Journal of Public Health and Community Medicine
Novie Homenta Rampengan
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Dentistry Health Professions Medicine & Pharmacology Nursing Public Health

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Comparative efficacy of artesunate and sulphadoxine-pyrimethamine combination with artesunate and amodiaquine combination in uncomplicated falciparum malaria in children Jose Meky Mandei; Novie Homenta Rampengan; Suryadi Nicolaas; Napoleon Tatura; Ari Lukas Runtunuwu; Tony Homenta Rampengan
Paediatrica Indonesiana Vol 48 No 4 (2008): July 2008
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi48.4.2008.240-5

Abstract

Background Malaria is still an important cause of mortalityand morbidity in children and adults in tropical countries.Multidrug resistance againts chloroquine and sulphadox-ine-pyrimethamine had brought to an introduction ofartemisinin-based combination.Objective To assess the alternative treatment of uncompli-cated falciparum malaria in children using artesunate andsulphadoxine-pyrimethamine combination comparing toartesunate and amodiaquine combination.Methods This is a single-blind randomized trial. Sixty-seven children aged six months to 13 years, were recruited.Thirty-three children were treated with artesunate 4 mg/kgbw/day for three days with an additional sulphadoxine-pyrimethamine (pyrimethamine 1-1.5 mg/kgbw) singledose on the first day, while 34 children were treated withartesunate and amodiaquine base 10 mg/kgbw/day for thefirst two days, then 5 mg/kgbw/day on the third day. Bodytemperature and parasite count were recorded everydayfor at least seven days. The outcomes were fever clearancetime, parasite clearance time, cure rate and side effects. Sta-tistical analysis was performed using the student t-test.Results The statistical analysis showed that there wereno difference between these two groups either in feverclearance time (P>0.05), or in parasite clearance time(P>0.05). The cure rate was 100% in both groups. Vomit-ing was found in one patient treated with artesunate andamodiaquine combination.Conclusion The combination of artesunate and sulpha-doxine-pyrimethamine and combination of artesunateand amodiaquine were found to be equally effective in thetreatment of uncomplicated falciparum malaria in children
Comparison of blood plasma and gelatin solution in resuscitation of children with dengue shock syndrome Suryadi Nicolaas Napoleon Tatura; Novie Homenta Rampengan; Jose Meky Mandei; Ari Lukas Runtunuwu; Max FJ Mantik; Tony Homenta Rampengan
Paediatrica Indonesiana Vol 49 No 6 (2009): November 2009
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (146.109 KB) | DOI: 10.14238/pi49.6.2009.322-9

Abstract

Background Dengue shock syndrome (DSS) is characterized bysevere vascular leakage and hemostasis disorder. It is the cause of death in 1 to 5 percent of cases. WH 0 management guidelines for resuscitation remain empirical rather than evidence-based.Objective To find out the alternative fluids to replace plasmaleakage in DSS.Methods We performed a prospective study and randomizedcomparison of plasma and gelatin solution for resuscitation ofIndonesian children with DSS. We randomly assigned 25 subjectswith DSS to receive plasma and 25 children to receive gelatinfluid. Statistical analyse were performed using chi-square test,Fisher's exact test, t test, Mann-Whitney test.Results The increment of pulse pressure width and the decrement of hematocrit in subjects treated with gelatin were higher than that of plasma atfour-hour therapy (P=0.002 and P=0.017). Only one patient died caused by unusually manifestation of DSS. The increment of body temperature in subjects treated with plasma was higher than that of gelatin at four-hour therapy (P=O.Oll). The decrement of platelet count in subjects treated with gelatin were less than that of plasma (P=0.018). The increment of diuresis rate in subjects treated with gelatin was higher than that of plasma at twenty-hour therapy (P<O.OOOl). The decrement of respiratory rate in subjects treated with gelatin was higher than that of plasmaat twenty-eight hour therapy (P=0.018). There was no differencein studied variables : total volume rate, blood pressure, pulse rate, re-shock rate, clinical fluid overload, allergy reactions, bleeding manifestations, and length of stay (P>0.05).Conclusions Gelatin solution can be used as volume replacementin resuscitation of DSS if blood plasma is not available especiallyat four-hour therapy.
Febrile neutropenia in childhood leukemia: Manado experience 1997 - 2006 Stefanus Gunawan; Novie Homenta Rampengan; Max Frans Joseph Mantik; Tonny Homenta Rampengan
Paediatrica Indonesiana Vol 49 No 6 (2009): November 2009
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (119.43 KB) | DOI: 10.14238/pi49.6.2009.372-8

Abstract

Background Febrile neutropenia (FNP) is a common complicationof therapy among children with cancer. It is one of the causes ofsignificant morbidity and mortality in children and young adultstreated for cancer. With aggressive management of FNP, theoutcome of episodes in children has improved dramatically.Objective To determine factors associated with FNP, to assess how varied the current management, and to evaluate the outcome of FNP in childhood leukemia in Manado over the last 10 years.Methods Data from medical records was collected retrospectivelyfrom January 1997 to December 2006. Variables studied were: age, sex, nutritional status, sosio-economic status, type of leukemia, degree of fever, ANC at fever, phase of chemotherapy, antibiotic used, episodes ofFNP and the outcome of patients.Results Twenty of ninety one patients were studied. The mortality rate was crucial i.e., 11 of20, it was higher in boys than that in girls. Most children have severe to very severe neutropenia and more than half died (7 /13). Seven out of 12 malnourished patients died. Sixteen children are suffered from acute lymphoblastic leukemia (ALL). The outcome of high risk (HR) patients was worse than that of standard risk (SR). FNP occurred along the phase of chemotherapy. None of the factors studied showed significant difference. The choice of antibiotics is varied.Conclusion The outcome of FNP in our institution is grave.There is a need to evaluate application and compliance to thestandard guidelines.
External risk factors associated with language disorders in children Lydia Wangke; Wenny Victory; Gregory Joey; Novie Homenta Rampengan; Hesti Lestari
Paediatrica Indonesiana Vol 61 No 3 (2021): May 2021
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi61.3.2021.133-40

Abstract

Background Children with language delay have deficits in the ability to learn and use language, either expressive and/or receptive despite otherwise normal development. Language delay could be influenced by either internal factors (within the child) and external factors (from the environment). Timely identification and modification of these risk factors can allow early intervention to reduce child disability and are associated with better long-term outcomes. Objective To identify possible risk factors related to language delay in children, such as bilingualism, socioeconomic status, maternal and caregiver education level, use of digital media, absence of story reading sessions, breastfeeding patterns, siblings, parenting methods, and maternal occupation. Methods This observational, analytic study included 102 children aged 24-36 months from four daycare centers in Manado, North Sulawesi, selected by cluster random sampling. Parents were interviewed to gather demographic information of child age, gender, presence of older siblings, maternal occupation, socioeconomic status, maternal/caregiver educational level, use of digital media, absence of story reading sessions, breastfeeding patterns, parenting methods, and bilingual environment. Children’s language development was assessed by the Capute Scales. Results Multivariate analysis revealed 2 factors significantly associated with increased risk of language delay; namely absence of storybook reading (OR=0.16; 95%CI 0.03 to 0.72; P=0.017) and bilingualism (OR=12.58; 95%CI 1.57 to 100.81; P=0.017). Conclusion Story reading sessions is associated with decreased risk of language delay, shile bilingualism is associatd with increased risk of language delay.
Pengetahuan, Sikap dan Tindakan Masyarakat tentang Kebijakan Pemerintah dalam Upaya Pengendalian Corona Virus Disease 2019 Vania Sartika Putri Lahinda; Oksfriani Jufri Sumampouw; Novie Homenta Rampengan
Indonesian Journal of Public Health and Community Medicine Vol. 2 No. 2 (2021): April 2021
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35801/ijphcm.v2i2.34585

Abstract

Background: Corona Virus Disease 2019 (Covid-19) has become a worldwide pandemic. Covid-19 is still a public health problem, especially in Indonesia. One of the problems to faced in controlling Covid-19 is community knowledge, attitudes and action. The purpose of this study is to description knowledge, attitudes and action on public actions regarding government policies in an effort to control Covid-19 in the city of Manado. Method: This is an observational study with a cross-sectional approach. The research was carried out in the Manado city in September 2020 - February 2021. The respondents in this study were residents of the Manado city who met the inclusion criteria. This study used 385 respondents. The research variables are knowledge, attitudes and actions. Informants were obtained using an online questionnaire using the google form application. Data analyzed univariatly. Results: The results showed that the most respondents are 17-25 years old (69.1%), female (66.2%), have college education (74.8%) and work as students (36.9%). Furthermore, most of the respondents fall into the very good category for knowledge (88.3%), attitude (67.0%) and action (54.8%). Conclusion: That can be conclude the people of the city of Manado have excellent knowledge, attitudes and actions about control policies of Covid-19. Therefore, it is necessary to continuously disseminate information about efforts to control and prevent Covid-19.
Co-Authors Ari Lukas Runtunuwu Gregory Joey Hesti Lestari Jose Meky Mandei Lydia Wangke Max FJ Mantik Max Frans Joseph Mantik Napoleon Tatura Rianna J Sumampouw Stefanus Gunawan Suryadi Nicolaas Suryadi Nicolaas Napoleon Tatura Tonny Homenta Rampengan Tony Homenta Rampengan Vania Sartika Putri Lahinda Wenny Victory